Gene Page: MBL2

Summary ?
GeneID4153
SymbolMBL2
SynonymsCOLEC1|HSMBPC|MBL|MBL2D|MBP|MBP-C|MBP1|MBPD
Descriptionmannose binding lectin 2
ReferenceMIM:154545|HGNC:HGNC:6922|Ensembl:ENSG00000165471|HPRD:01107|Vega:OTTHUMG00000150270
Gene typeprotein-coding
Map location10q11.2
Pascal p-value0.744
Fetal beta0.06

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005102receptor bindingIPINeurotransmitter (GO term level: 4)11549596 
GO:0005529sugar bindingIEA-
GO:0005537mannose bindingNAS11549596 
GO:0005488bindingIEA-
GO:0005509calcium ion bindingIEA-
GO:0043499eukaryotic cell surface bindingTAS2477488 
GO:0051635bacterial cell surface bindingTAS2477488 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001867complement activation, lectin pathwayEXP11532276 
GO:0001867complement activation, lectin pathwayIPI11549596 
GO:0006979response to oxidative stressNAS11549596 
GO:0006958complement activation, classical pathwayIEA-
GO:0006953acute-phase responseTAS2477488 
GO:0008228opsonizationTAS2477488 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionEXP10639434 |10925294 
GO:0005615extracellular spaceTAS1304173 
GO:0005634nucleusIDA18029348 
GO:0005730nucleolusIDA18029348 
GO:0005737cytoplasmIDA18029348 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG COMPLEMENT AND COAGULATION CASCADES 6949All SZGR 2.0 genes in this pathway
BIOCARTA COMP PATHWAY 1915All SZGR 2.0 genes in this pathway
BIOCARTA LECTIN PATHWAY 1210All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM 279178All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME COMPLEMENT CASCADE 3222All SZGR 2.0 genes in this pathway
REACTOME CREATION OF C4 AND C2 ACTIVATORS 105All SZGR 2.0 genes in this pathway
REACTOME INITIAL TRIGGERING OF COMPLEMENT 1610All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM4 261153All SZGR 2.0 genes in this pathway
LEE LIVER CANCER CIPROFIBRATE DN 6643All SZGR 2.0 genes in this pathway
LEE LIVER CANCER ACOX1 DN 6539All SZGR 2.0 genes in this pathway
HSIAO LIVER SPECIFIC GENES 244154All SZGR 2.0 genes in this pathway
ZHU CMV 24 HR DN 9164All SZGR 2.0 genes in this pathway
ZHU CMV ALL DN 12893All SZGR 2.0 genes in this pathway
SU LIVER 5532All SZGR 2.0 genes in this pathway
YANG MUC2 TARGETS DUODENUM 6MO UP 105All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR UP 17496All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973570All SZGR 2.0 genes in this pathway
BOCHKIS FOXA2 TARGETS 425261All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
OHGUCHI LIVER HNF4A TARGETS DN 14985All SZGR 2.0 genes in this pathway
FOSTER KDM1A TARGETS UP 266142All SZGR 2.0 genes in this pathway
NABA ECM AFFILIATED 17189All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway