Gene Page: MYH7

Summary ?
GeneID4625
SymbolMYH7
SynonymsCMD1S|CMH1|MPD1|MYHCB|SPMD|SPMM
Descriptionmyosin, heavy chain 7, cardiac muscle, beta
ReferenceMIM:160760|HGNC:HGNC:7577|Ensembl:ENSG00000092054|HPRD:01175|Vega:OTTHUMG00000028755
Gene typeprotein-coding
Map location14q12
Pascal p-value0.177
Sherlock p-value0.028
Fetal beta-0.742
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IGenome scan meta-analysisPsr: 0.047 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs10783884chr1258575526MYH746250.18trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
GOLIM40.860.85
TLN10.850.85
DOCK10.830.82
RIN20.800.79
LRIG10.800.84
FGFR20.800.77
KIAA11610.800.82
BMP70.790.78
GPT20.790.76
USP400.790.79
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C20orf7-0.46-0.50
PSMA6-0.42-0.49
ZNF32-0.41-0.47
GTF3A-0.41-0.45
COX5A-0.40-0.42
ST20-0.40-0.44
HINT1-0.40-0.42
NDUFAF2-0.40-0.44
NOP10-0.39-0.45
PFDN5-0.39-0.47

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000146microfilament motor activityNAS3021460 
GO:0000166nucleotide bindingIEA-
GO:0003779actin bindingIEA-
GO:0005516calmodulin bindingIEA-
GO:0005524ATP bindingIC16088376 
GO:0008307structural constituent of muscleIDA15621050 |16088376 
GO:0016887ATPase activityIDA15621050 
GO:0030898actin-dependent ATPase activityIMP16088376 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0002027regulation of heart rateIDA15621050 
GO:0055010ventricular cardiac muscle morphogenesisIMP15856146 
GO:0006200ATP catabolic processIDA15621050 
GO:0007512adult heart developmentIMP15856146 
GO:0006941striated muscle contractionIEA-
GO:0030049muscle filament slidingIMP8514894 |16088376 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005863striated muscle thick filamentIEA-
GO:0005634nucleusIDA18029348 
GO:0005730nucleolusIDA18029348 
GO:0005737cytoplasmIEA-
GO:0005925focal adhesionIDA18029348 
GO:0016459myosin complexTAS12933792 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CARDIAC MUSCLE CONTRACTION 8051All SZGR 2.0 genes in this pathway
KEGG TIGHT JUNCTION 13486All SZGR 2.0 genes in this pathway
KEGG HYPERTROPHIC CARDIOMYOPATHY HCM 8565All SZGR 2.0 genes in this pathway
KEGG DILATED CARDIOMYOPATHY 9268All SZGR 2.0 genes in this pathway
KEGG VIRAL MYOCARDITIS 7358All SZGR 2.0 genes in this pathway
SHETH LIVER CANCER VS TXNIP LOSS PAM5 9459All SZGR 2.0 genes in this pathway
AFFAR YY1 TARGETS UP 214133All SZGR 2.0 genes in this pathway
LEE AGING CEREBELLUM DN 8666All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION MUSCLE UP 4333All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN 940425All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS UP 491316All SZGR 2.0 genes in this pathway
SWEET KRAS ONCOGENIC SIGNATURE 8956All SZGR 2.0 genes in this pathway
HOFFMANN SMALL PRE BII TO IMMATURE B LYMPHOCYTE UP 7049All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 1 6850All SZGR 2.0 genes in this pathway
VANDESLUIS COMMD1 TARGETS GROUP 3 UP 8950All SZGR 2.0 genes in this pathway
WANG NFKB TARGETS 2515All SZGR 2.0 genes in this pathway
CHEMELLO SOLEUS VS EDL MYOFIBERS UP 3516All SZGR 2.0 genes in this pathway