Gene Page: NOS3

Summary ?
GeneID4846
SymbolNOS3
SynonymsECNOS|eNOS
Descriptionnitric oxide synthase 3
ReferenceMIM:163729|HGNC:HGNC:7876|Ensembl:ENSG00000164867|HPRD:01224|Vega:OTTHUMG00000158343
Gene typeprotein-coding
Map location7q36
Pascal p-value0.26
TADA p-value0.023
eGeneMyers' cis & trans
Meta
SupportCompositeSet

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DNM:Fromer_2014Whole Exome Sequencing analysisThis study reported a WES study of 623 schizophrenia trios, reporting DNMs using genomic DNA.
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@DNM table

GeneChromosomePositionRefAltTranscriptAA changeMutation typeSiftCG46TraitStudy
NOS3chr7150707820TGNM_000603p.941S>AmissenseSchizophreniaDNM:Fromer_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs73705640NOS348460.15trans
rs443832chr1683779643NOS348460.18trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003785actin monomer bindingIPI17502619 
GO:0005506iron ion bindingIEA-
GO:0005509calcium ion bindingIEA-
GO:0005516calmodulin bindingIEA-
GO:0004517nitric-oxide synthase activityIEA-
GO:0020037heme bindingIEA-
GO:0008270zinc ion bindingIEA-
GO:0010181FMN bindingIEA-
GO:0009055electron carrier activityIEA-
GO:0016491oxidoreductase activityIEA-
GO:0034617tetrahydrobiopterin bindingIDA7488039 
GO:0034618arginine bindingIDA7488039 
GO:0046870cadmium ion bindingNAS7488039 
GO:0050660FAD bindingIEA-
GO:0050661NADP bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001542ovulation from ovarian follicleIEA-
GO:0002028regulation of sodium ion transportIEA-
GO:0003100regulation of systemic arterial blood pressure by endothelinIMP8999856 
GO:0001974blood vessel remodelingISS-
GO:0006527arginine catabolic processIDA1378832 |7488039 
GO:0008217regulation of blood pressureNAS7504210 
GO:0010544negative regulation of platelet activationNAS7504210 
GO:0008285negative regulation of cell proliferationISS-
GO:0009408response to heatNAS18048451 
GO:0007612learningIEA-
GO:0006809nitric oxide biosynthetic processIEA-
GO:0007005mitochondrion organizationISS-
GO:0006916anti-apoptosisISS-
GO:0014740negative regulation of muscle hyperplasiaISS-
GO:0014806smooth muscle hyperplasiaISS-
GO:0051346negative regulation of hydrolase activityIEA-
GO:0031284positive regulation of guanylate cyclase activityIMP17502619 
GO:0031284positive regulation of guanylate cyclase activityISS-
GO:0034405response to fluid shear stressIEP10376603 
GO:0030324lung developmentIEA-
GO:0031663lipopolysaccharide-mediated signaling pathwayIEA-
GO:0043267negative regulation of potassium ion transportIEA-
GO:0045766positive regulation of angiogenesisISS-
GO:0045909positive regulation of vasodilationNAS18048451 
GO:0050880regulation of blood vessel sizeISS-
GO:0050880regulation of blood vessel sizeNAS7504210 
GO:0043542endothelial cell migrationIMP8999856 
GO:0055114oxidation reductionIEA-
GO:0051926negative regulation of calcium ion transportIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000139Golgi membraneEXP9188442 |9580552 |10781589 
|11149895 |16722822 
|16807357 
GO:0005794Golgi apparatusIEA-
GO:0005829cytosolEXP7512951 |10559837 
GO:0005856cytoskeletonIEA-
GO:0005634nucleusISS-
GO:0005737cytoplasmIEA-
GO:0005901caveolaIDA17502619 |17848177 
GO:0005886plasma membraneIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG ARGININE AND PROLINE METABOLISM 5439All SZGR 2.0 genes in this pathway
KEGG CALCIUM SIGNALING PATHWAY 178134All SZGR 2.0 genes in this pathway
KEGG VEGF SIGNALING PATHWAY 7653All SZGR 2.0 genes in this pathway
BIOCARTA NO1 PATHWAY 3324All SZGR 2.0 genes in this pathway
BIOCARTA GCR PATHWAY 2217All SZGR 2.0 genes in this pathway
BIOCARTA HIF PATHWAY 1512All SZGR 2.0 genes in this pathway
BIOCARTA VEGF PATHWAY 2918All SZGR 2.0 genes in this pathway
PID ER NONGENOMIC PATHWAY 4135All SZGR 2.0 genes in this pathway
PID FRA PATHWAY 3728All SZGR 2.0 genes in this pathway
PID ANGIOPOIETIN RECEPTOR PATHWAY 5041All SZGR 2.0 genes in this pathway
PID TXA2PATHWAY 5743All SZGR 2.0 genes in this pathway
PID SHP2 PATHWAY 5846All SZGR 2.0 genes in this pathway
PID VEGFR1 PATHWAY 2623All SZGR 2.0 genes in this pathway
PID VEGFR1 2 PATHWAY 6957All SZGR 2.0 genes in this pathway
PID THROMBIN PAR1 PATHWAY 4332All SZGR 2.0 genes in this pathway
REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION 139All SZGR 2.0 genes in this pathway
REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS 3315All SZGR 2.0 genes in this pathway
REACTOME ENOS ACTIVATION AND REGULATION 2014All SZGR 2.0 genes in this pathway
REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE 2519All SZGR 2.0 genes in this pathway
REACTOME PLATELET HOMEOSTASIS 7849All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP 473314All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION DN 234147All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP 612367All SZGR 2.0 genes in this pathway
HATADA METHYLATED IN LUNG CANCER UP 390236All SZGR 2.0 genes in this pathway
SANA TNF SIGNALING DN 9057All SZGR 2.0 genes in this pathway
MARIADASON REGULATED BY HISTONE ACETYLATION UP 8349All SZGR 2.0 genes in this pathway
LEE AGING CEREBELLUM UP 8458All SZGR 2.0 genes in this pathway
HILLION HMGA1B TARGETS 9268All SZGR 2.0 genes in this pathway
MATZUK OVULATION 1410All SZGR 2.0 genes in this pathway
MATZUK MEIOTIC AND DNA REPAIR 3926All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE 242168All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP 165118All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER GOOD SURVIVAL A4 196124All SZGR 2.0 genes in this pathway
MIKKELSEN IPS LCP WITH H3K4ME3 174100All SZGR 2.0 genes in this pathway
MIKKELSEN ES LCP WITH H3K4ME3 14280All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 3 DN 4224All SZGR 2.0 genes in this pathway
FOSTER KDM1A TARGETS DN 211119All SZGR 2.0 genes in this pathway