Gene Page: NTRK1

Summary
GeneID  4914
Symbol  NTRK1
Synonyms  DKFZp781I14186|MTC|TRK|TRK1|TRKA|p140-TrkA
Description  neurotrophic tyrosine kinase, receptor, type 1
See related  HGNC:8031|MIM:191315|Ensembl:ENSG00000198400|HPRD:01869|
Locus tag  -
Gene type  protein-coding
Map location  1q21-q22
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0235 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00814 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 4 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004714transmembrane receptor protein tyrosine kinase activityNASneurite (GO term level: 8)1695324 
GO:0004714transmembrane receptor protein tyrosine kinase activityTASneurite (GO term level: 8)1695324 |8957089 
GO:0043121neurotrophin bindingTASneuron (GO term level: 5)9290260 
GO:0000166nucleotide bindingIEA-
GO:0004872receptor activityIEA-
GO:0005515protein bindingIEA-
GO:0005524ATP bindingIEA-
GO:0016740transferase activityIEA-
GO:0016301kinase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007399nervous system developmentIEAneurite (GO term level: 5)-
GO:0007190activation of adenylate cyclase activityEXP16805430 
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayEXP16939974 
GO:0007169transmembrane receptor protein tyrosine kinase signaling pathwayTAS9290260 
GO:0006468protein amino acid phosphorylationIEA-
GO:0006468protein amino acid phosphorylationNAS-
GO:0007265Ras protein signal transductionEXP11520933 
GO:0008150biological_processND1695324 
GO:0007275multicellular organismal developmentIEA-
GO:0030154cell differentiationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005575cellular_componentND1695324 
GO:0005768endosomeEXP7806500 |9182757 |10629055 
|16284401 
GO:0016021integral to membraneNAS-
GO:0005886plasma membraneEXP11157096 |16284401 
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS9290260 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinase-HPRD,BioGRID10679771 |10708759 
CAV1CAV | MSTP085 | VIP21caveolin 1, caveolae protein, 22kDa-HPRD,BioGRID9867838 
FRS2FRS2A | FRS2alpha | SNT | SNT-1 | SNT1fibroblast growth factor receptor substrate 2TrkA interacts with FRS2-alpha. This interaction was modelled on a demonstrated interaction between human TrkA and mouse FRS2-alpha.BIND10629055 
-HPRD,BioGRID10092678 
FRS3FRS2B | FRS2beta | MGC17167 | SNT-2 | SNT2fibroblast growth factor receptor substrate 3TrkA interacts with FRS2-beta.BIND10629055 
GIPC1C19orf3 | GIPC | GLUT1CBP | Hs.6454 | IIP-1 | MGC15889 | MGC3774 | NIP | RGS19IP1 | SEMCAP | SYNECTIIN | SYNECTIN | TIP-2GIPC PDZ domain containing family, member 1GIPC interacts with TRKA. This interaction was modelled on a demonstrated interaction between mouse GIPC and rat TrkA.BIND11251075 
-HPRD,BioGRID11251075 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD,BioGRID10748052 |11733534 
KIDINS220ARMS | MGC163482kinase D-interacting substrate, 220kDa-HPRD11150334 |15167895 
MATKCHK | CTK | DKFZp434N1212 | HHYLTK | HYL | HYLTK | Lsk | MGC1708 | MGC2101megakaryocyte-associated tyrosine kinase-HPRD,BioGRID10329710 
NGFBeta-NGF | HSAN5 | MGC161426 | MGC161428 | NGFBnerve growth factor (beta polypeptide)Interaction between TrkA (PDB ID: 1WWW_Y) and NGF (PDB ID: 1WWW_W).BIND10490030 
NGF interacts with TrkA. This interaction was modeled on a demonstrated interaction between NGF from human and TrkA from an unspecified species.BIND14985763 
Interaction between TrkA (PDB ID: 1WWW_Y) and NGF (PDB ID: 1WWW_V).BIND10490030 
-HPRD,BioGRID14985763 
Interaction between TrkA (PDB ID: 1WWW_X) and NGF (PDB ID: 1WWW_V).BIND10490030 
Interaction between TrkA (PDB ID: 1WWW_X) and NGF (PDB ID: 1WWW_W).BIND10490030 
NTF3HDNF | MGC129711 | NGF-2 | NGF2 | NT3neurotrophin 3Reconstituted ComplexBioGRID8621424 
NTRK1DKFZp781I14186 | MTC | TRK | TRK1 | TRKA | p140-TrkAneurotrophic tyrosine kinase, receptor, type 1-HPRD,BioGRID10388563 
PLCG1PLC-II | PLC1 | PLC148 | PLCgamma1phospholipase C, gamma 1-HPRD,BioGRID1715690 
PTPN1PTP1Bprotein tyrosine phosphatase, non-receptor type 1-HPRD,BioGRID12237455 
RAP1AKREV-1 | KREV1 | RAP1 | SMGP21RAP1A, member of RAS oncogene familyAffinity Capture-WesternBioGRID11466412 
RGS19GAIP | RGSGAIPregulator of G-protein signaling 19Affinity Capture-WesternBioGRID11251075 
RICSGC-GAP | GRIT | KIAA0712 | MGC1892 | p200RhoGAP | p250GAPRho GTPase-activating protein-HPRD,BioGRID12446789 
RUSC1DKFZp761A1822 | NESCARUN and SH3 domain containing 1-HPRD15024033 
SH2B1DKFZp547G1110 | FLJ30542 | KIAA1299 | SH2-B | SH2BSH2B adaptor protein 1-HPRD10708759 
-HPRD,BioGRID9856458 
SH2B2APSSH2B adaptor protein 2Affinity Capture-Western
Two-hybrid		BioGRID9856458 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1Shc interacts with Trk. This interaction was modelled on a demonstrated interaction between SHC from rat or mouse and Trk from human.BIND8155326 
Shc interacts with NGFR.BIND8577769 
ShcA interacts with TrkA.BIND7542991 |8610109 
|8943228 
Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID8183561 |9856458 
|10092678 |10708759 
|12446789 
SHC3N-Shc | NSHC | RAI | SHCCSHC (Src homology 2 domain containing) transforming protein 3-HPRD,BioGRID9507002 
SQSTM1A170 | OSIL | PDB3 | ZIP3 | p60 | p62 | p62Bsequestosome 1Affinity Capture-WesternBioGRID11244088 |12471037 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_ENDOCYTOSIS 183132All SZGR genes in this pathway
KEGG_APOPTOSIS 8862All SZGR genes in this pathway
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 126103All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_THYROID_CANCER 2926All SZGR genes in this pathway
BIOCARTA_ERK5_PATHWAY 1815All SZGR genes in this pathway
BIOCARTA_TRKA_PATHWAY 1210All SZGR genes in this pathway
BIOCARTA_ACTINY_PATHWAY 2014All SZGR genes in this pathway
ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS 4535All SZGR genes in this pathway
SA_TRKA_RECEPTOR 1715All SZGR genes in this pathway
PID_P73PATHWAY 7959All SZGR genes in this pathway
PID_SHP2_PATHWAY 5846All SZGR genes in this pathway
PID_P75_NTR_PATHWAY 6951All SZGR genes in this pathway
PID_TRKR_PATHWAY 6248All SZGR genes in this pathway
PID_PI3K_PLC_TRK_PATHWAY 3631All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_ARMS_MEDIATED_ACTIVATION 1717All SZGR genes in this pathway
REACTOME_PROLONGED_ERK_ACTIVATION_EVENTS 1918All SZGR genes in this pathway
REACTOME_SIGNALLING_TO_RAS 2723All SZGR genes in this pathway
REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 137105All SZGR genes in this pathway
REACTOME_SIGNALLING_TO_ERKS 3630All SZGR genes in this pathway
REACTOME_SIGNALLING_TO_P38_VIA_RIT_AND_RIN 1514All SZGR genes in this pathway
REACTOME_RETROGRADE_NEUROTROPHIN_SIGNALLING 137All SZGR genes in this pathway
REACTOME_PI3K_AKT_ACTIVATION 3829All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
TANAKA_METHYLATED_IN_ESOPHAGEAL_CARCINOMA 10358All SZGR genes in this pathway
MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_17 2512All SZGR genes in this pathway
MYLLYKANGAS_AMPLIFICATION_HOT_SPOT_24 147All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_DN 193112All SZGR genes in this pathway
BENPORATH_SUZ12_TARGETS 1038678All SZGR genes in this pathway
BENPORATH_EED_TARGETS 1062725All SZGR genes in this pathway
BENPORATH_ES_WITH_H3K27ME3 1118744All SZGR genes in this pathway
BENPORATH_PRC2_TARGETS 652441All SZGR genes in this pathway
PETRETTO_BLOOD_PRESSURE_UP 128All SZGR genes in this pathway
DING_LUNG_CANCER_MUTATED_SIGNIFICANTLY 2622All SZGR genes in this pathway
RADAEVA_RESPONSE_TO_IFNA1_UP 5240All SZGR genes in this pathway
YAGI_AML_FAB_MARKERS 191131All SZGR genes in this pathway
RIGGI_EWING_SARCOMA_PROGENITOR_UP 430288All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
FIRESTEIN_PROLIFERATION 175125All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
YAGI_AML_WITH_INV_16_TRANSLOCATION 422277All SZGR genes in this pathway
YAGI_AML_WITH_11Q23_REARRANGED 351238All SZGR genes in this pathway
ASGHARZADEH_NEUROBLASTOMA_POOR_SURVIVAL_DN 4630All SZGR genes in this pathway


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