Gene Page: ATP5B

Summary
GeneID  506
Symbol  ATP5B
Synonyms  ATPMB|ATPSB|MGC5231
Description  ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
See related  HGNC:830|MIM:102910|Ensembl:ENSG00000110955|HPRD:00044|
Locus tag  -
Gene type  protein-coding
Map location  12q13.13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0296 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SUCLG10.940.91
PSMA60.920.91
MRPL10.920.93
ZNHIT30.920.90
MRPL150.910.90
CHMP50.900.88
NFU10.900.91
VPS290.890.91
MRPL470.890.89
C11orf730.890.87
Top 10 negatively co-expressed genes
FAM38A-0.57-0.62
PPP1R13L-0.56-0.55
AF347015.26-0.55-0.53
TRIM56-0.55-0.59
AF347015.18-0.55-0.50
DOCK6-0.54-0.56
MYH9-0.54-0.53
AF347015.2-0.54-0.51
RRBP1-0.53-0.56
TENC1-0.52-0.58
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIPI11410595 
GO:0005524ATP bindingIEA-
GO:0016787hydrolase activityIEA-
GO:0005215transporter activityNAS2870059 
GO:0008553hydrogen-exporting ATPase activity, phosphorylative mechanismIEA-
GO:0016887ATPase activityIDA12110673 
GO:0042288MHC class I protein bindingIDA17643490 
GO:0043499eukaryotic cell surface bindingIDA10077593 
GO:0046933hydrogen ion transporting ATP synthase activity, rotational mechanismIEA-
GO:0046872metal ion bindingIEA-
GO:0046961hydrogen ion transporting ATPase activity, rotational mechanismIMP17510399 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001525angiogenesisIMP17510399 
GO:0006091generation of precursor metabolites and energyNAS2870059 
GO:0006811ion transportIEA-
GO:0015992proton transportIMP17510399 
GO:0015986ATP synthesis coupled proton transportIEA-
GO:0051453regulation of intracellular pHIMP17510399 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005739mitochondrionIDA2870059 
GO:0005753mitochondrial proton-transporting ATP synthase complexIDA12110673 
GO:0005753mitochondrial proton-transporting ATP synthase complexNAS2900241 
GO:0005754mitochondrial proton-transporting ATP synthase, catalytic coreNAS2687158 |2870059 
GO:0005759mitochondrial matrixEXP4517936 
GO:0005759mitochondrial matrixNAS2687158 
GO:0016021integral to membraneIEA-
GO:0009986cell surfaceIDA17510399 
GO:0005886plasma membraneIDA10077593 
GO:0016469proton-transporting two-sector ATPase complexIEA-
GO:0045261proton-transporting ATP synthase complex, catalytic core F(1)IEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATPAF1ATP11 | ATP11p | FLJ22351 | MGC88060ATP synthase mitochondrial F1 complex assembly factor 1-HPRD12206899 
ATPAF2ATP12 | ATP12p | LP3663 | MGC29736ATP synthase mitochondrial F1 complex assembly factor 2-HPRD,BioGRID11410595 
FANCAFA | FA-H | FA1 | FAA | FACA | FAH | FANCH | MGC75158Fanconi anemia, complementation group ATwo-hybridBioGRID14499622 
PLGDKFZp779M0222plasminogen-HPRD10077593 
PSME3Ki | PA28-gamma | PA28G | REG-GAMMAproteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)Two-hybridBioGRID16169070 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_OXIDATIVE_PHOSPHORYLATION 13573All SZGR genes in this pathway
KEGG_ALZHEIMERS_DISEASE 169110All SZGR genes in this pathway
KEGG_PARKINSONS_DISEASE 13378All SZGR genes in this pathway
KEGG_HUNTINGTONS_DISEASE 185109All SZGR genes in this pathway
REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT 14185All SZGR genes in this pathway
REACTOME_MITOCHONDRIAL_PROTEIN_IMPORT 5824All SZGR genes in this pathway
REACTOME_METABOLISM_OF_PROTEINS 518242All SZGR genes in this pathway
REACTOME_RESPIRATORY_ELECTRON_TRANSPORT_ATP_SYNTHESIS_BY_CHEMIOSMOTIC_COUPLING_AND_HEAT_PRODUCTION_BY_UNCOUPLING_PROTEINS_ 9856All SZGR genes in this pathway
REACTOME_FORMATION_OF_ATP_BY_CHEMIOSMOTIC_COUPLING 169All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_DN 485334All SZGR genes in this pathway
OUELLET_OVARIAN_CANCER_INVASIVE_VS_LMP_UP 11785All SZGR genes in this pathway
APPIERTO_RESPONSE_TO_FENRETINIDE_DN 5135All SZGR genes in this pathway
KIM_MYC_AMPLIFICATION_TARGETS_UP 201127All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
ALCALA_APOPTOSIS 8860All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN 206136All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
MOOTHA_VOXPHOS 8751All SZGR genes in this pathway
NING_CHRONIC_OBSTRUCTIVE_PULMONARY_DISEASE_UP 157105All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_DN 2515All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
KAYO_CALORIE_RESTRICTION_MUSCLE_DN 8759All SZGR genes in this pathway
HEDENFALK_BREAST_CANCER_BRACX_UP 2014All SZGR genes in this pathway
MARIADASON_RESPONSE_TO_BUTYRATE_SULINDAC_6 5232All SZGR genes in this pathway
HILLION_HMGA1B_TARGETS 9268All SZGR genes in this pathway
LEIN_LOCALIZED_TO_PROXIMAL_DENDRITES 3726All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_T7 9863All SZGR genes in this pathway
WONG_MITOCHONDRIA_GENE_MODULE 217122All SZGR genes in this pathway
MOOTHA_HUMAN_MITODB_6_2002 429260All SZGR genes in this pathway
MOOTHA_MITOCHONDRIA 447277All SZGR genes in this pathway
HSIAO_HOUSEKEEPING_GENES 389245All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
MIKHAYLOVA_OXIDATIVE_STRESS_RESPONSE_VIA_VHL_UP 76All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_DN 448282All SZGR genes in this pathway


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