Gene Page: PAK3

Summary
GeneID  5063
Symbol  PAK3
Synonyms  CDKN1A|MRX30|MRX47|OPHN3|PAK3beta|bPAK|hPAK3
Description  p21 protein (Cdc42/Rac)-activated kinase 3
See related  HGNC:8592|MIM:300142|Ensembl:ENSG00000077264|HPRD:02142|
Locus tag  RP5-914P14.3
Gene type  protein-coding
Map location  Xq22.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
OAT0.750.79
AAGAB0.740.77
RSRC10.740.71
AUH0.710.66
SUCLA20.700.71
TBK10.700.68
ATP1B10.700.74
NDRG40.700.71
PFKP0.700.70
C13orf10.700.71
Top 10 negatively co-expressed genes
AF347015.21-0.40-0.14
AF347015.18-0.37-0.14
FAM159B-0.36-0.33
AF347015.2-0.32-0.14
AC100783.1-0.32-0.22
CLEC3B-0.31-0.31
AC098691.2-0.31-0.19
SIGIRR-0.31-0.37
IL32-0.30-0.10
AF347015.8-0.30-0.11
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingIEA-
GO:0005524ATP bindingIEA-
GO:0004674protein serine/threonine kinase activityIEA-
GO:0016740transferase activityIEA-
GO:0017124SH3 domain bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006468protein amino acid phosphorylationIEA-
GO:0007275multicellular organismal developmentIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARHGEF6COOL2 | Cool-2 | KIAA0006 | MRX46 | PIXA | alpha-PIX | alphaPIXRac/Cdc42 guanine nucleotide exchange factor (GEF) 6-HPRD,BioGRID9659915 
ARHGEF7BETA-PIX | COOL1 | DKFZp686C12170 | DKFZp761K1021 | KIAA0142 | KIAA0412 | Nbla10314 | P50 | P50BP | P85 | P85COOL1 | P85SPR | PAK3 | PIXBRho guanine nucleotide exchange factor (GEF) 7-HPRD,BioGRID9726964 
GIT1-G protein-coupled receptor kinase interacting ArfGAP 1-HPRD10896954 
GIT2CAT-2 | DKFZp686G01261 | KIAA0148 | MGC760G protein-coupled receptor kinase interacting ArfGAP 2-HPRD10896954 
MAP3K1MAPKKK1 | MEKK | MEKK1mitogen-activated protein kinase kinase kinase 1in vivoBioGRID9065412 
PXNFLJ16691paxillin-HPRD11096073 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)Reconstituted Complex
Two-hybrid		BioGRID11478794 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_ERBB_SIGNALING_PATHWAY 8771All SZGR genes in this pathway
KEGG_AXON_GUIDANCE 129103All SZGR genes in this pathway
KEGG_FOCAL_ADHESION 201138All SZGR genes in this pathway
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 10889All SZGR genes in this pathway
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
KEGG_RENAL_CELL_CARCINOMA 7060All SZGR genes in this pathway
BIOCARTA_AGR_PATHWAY 3631All SZGR genes in this pathway
SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES 6754All SZGR genes in this pathway
SIG_CHEMOTAXIS 4537All SZGR genes in this pathway
SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES 3525All SZGR genes in this pathway
ST_INTEGRIN_SIGNALING_PATHWAY 8262All SZGR genes in this pathway
ST_T_CELL_SIGNAL_TRANSDUCTION 4533All SZGR genes in this pathway
PID_P38_ALPHA_BETA_PATHWAY 3125All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
STREICHER_LSM1_TARGETS_UP 4434All SZGR genes in this pathway
WONG_ENDMETRIUM_CANCER_DN 8253All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_5 14789All SZGR genes in this pathway
JAZAG_TGFB1_SIGNALING_VIA_SMAD4_DN 6638All SZGR genes in this pathway
DING_LUNG_CANCER_MUTATED_SIGNIFICANTLY 2622All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
MUNSHI_MULTIPLE_MYELOMA_UP 8152All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_UP 240152All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_16HR_UP 225139All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_18HR_UP 178111All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_DN 165106All SZGR genes in this pathway
MUELLER_PLURINET 299189All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A12 317177All SZGR genes in this pathway
YAGI_AML_WITH_INV_16_TRANSLOCATION 422277All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_PRONEURAL 177132All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
GOBERT_CORE_OLIGODENDROCYTE_DIFFERENTIATION 4028All SZGR genes in this pathway
RATTENBACHER_BOUND_BY_CELF1 467251All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-103/10757631Ahsa-miR-103brainAGCAGCAUUGUACAGGGCUAUGA
hsa-miR-107brainAGCAGCAUUGUACAGGGCUAUCA
miR-122317323m8hsa-miR-122aUGGAGUGUGACAAUGGUGUUUGU
miR-149253259m8hsa-miR-149brainUCUGGCUCCGUGUCUUCACUCC
miR-1932552611Ahsa-miR-193aAACUGGCCUACAAAGUCCCAG
hsa-miR-193bAACUGGCCCUCAAAGUCCCGCUUU
miR-5393033091Ahsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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