Gene Page: PARK2

Summary
GeneID  5071
Symbol  PARK2
Synonyms  AR-JP|LPRS2|PDJ|PRKN
Description  Parkinson disease (autosomal recessive, juvenile) 2, parkin
See related  HGNC:8607|MIM:602544|Ensembl:ENSG00000185345|HPRD:03967|
Locus tag  -
Gene type  protein-coding
Map location  6q25.2-q27
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 1.0504 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI11590439 |12364339 |16352719 
|17097639 
GO:0004842ubiquitin-protein ligase activityIDA17097639 
GO:0016874ligase activityIEA-
GO:0016881acid-amino acid ligase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007417central nervous system developmentTASBrain (GO term level: 6)9560156 
GO:0006464protein modification processIEA-
GO:0042787protein ubiquitination during ubiquitin-dependent protein catabolic processIDA17097639 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005794Golgi apparatusIDA17097639 
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-
GO:0048471perinuclear region of cytoplasmIDA17097639 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BAG5BAG-5BCL2-associated athanogene 5BAG5 interacts with parkin.BIND15603737 
CAMK2ACAMKA | KIAA0968calcium/calmodulin-dependent protein kinase II alphaAffinity Capture-WesternBioGRID11679592 
CASKCAGH39 | CMG | FLJ22219 | FLJ31914 | LIN2 | MICPCH | TNRC8calcium/calmodulin-dependent serine protein kinase (MAGUK family)-HPRD,BioGRID11679592 
CASP1ICE | IL1BC | P45caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)-HPRD12692130 
CCNA1-cyclin A1Affinity Capture-WesternBioGRID12628165 
CCNE1CCNEcyclin E1Affinity Capture-WesternBioGRID12628165 
CUL1MGC149834 | MGC149835cullin 1Affinity Capture-Western
Reconstituted Complex		BioGRID12628165 
DLG4FLJ97752 | FLJ98574 | PSD95 | SAP90discs, large homolog 4 (Drosophila)Affinity Capture-WesternBioGRID11679592 
FBXW7AGO | CDC4 | DKFZp686F23254 | FBW6 | FBW7 | FBX30 | FBXO30 | FBXW6 | FLJ16457 | SEL-10 | SEL10F-box and WD repeat domain containing 7-HPRD,BioGRID12628165 
GPR37EDNRBL | PAELR | hET(B)R-LPG protein-coupled receptor 37 (endothelin receptor type B-like)-HPRD,BioGRID11439185 |12150907 
GRIN2BMGC142178 | MGC142180 | NMDAR2B | NR2B | hNR3glutamate receptor, ionotropic, N-methyl D-aspartate 2B-HPRD,BioGRID11679592 
HOMER1HOMER | HOMER1A | HOMER1B | HOMER1C | SYN47 | Ves-1homer homolog 1 (Drosophila)Affinity Capture-WesternBioGRID11679592 
JTV1AIMP2 | P38 | PRO0992JTV1 gene-HPRD,BioGRID12783850 
NDUFA4L2FLJ26118 | NUOMSNADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2Two-hybridBioGRID16169070 
PAFAH1B2-platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30kDaTwo-hybridBioGRID16169070 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)Two-hybridBioGRID16169070 
RAD1HRAD1 | REC1RAD1 homolog (S. pombe)Two-hybridBioGRID16169070 
RGS2G0S8regulator of G-protein signaling 2, 24kDaTwo-hybridBioGRID16169070 
SEPT4ARTS | BRADEION | CE5B3 | H5 | MART | PNUTL2 | SEP4 | hCDCREL-2 | hucep-7septin 4-HPRD14559152 
SEPT5CDCREL | CDCREL-1 | CDCREL1 | H5 | PNUTL1septin 5-HPRD,BioGRID11078524 
SNCAMGC110988 | NACP | PARK1 | PARK4 | PD1synuclein, alpha (non A4 component of amyloid precursor)-HPRD,BioGRID11588587 
SNCAIPMGC39814 | SYPH1synuclein, alpha interacting protein-HPRD,BioGRID11590439 
Synphilin-1 is ubiquitinated by Parkin.BIND15105460 
Synphilin interacts with parkin.BIND15603737 
SYT11DKFZp781D015 | KIAA0080 | MGC10881 | MGC17226 | SYT12synaptotagmin XI-HPRD,BioGRID12925569 
TRIP1316E1BPthyroid hormone receptor interactor 13Two-hybridBioGRID16189514 
UBBFLJ25987 | MGC8385ubiquitin BParkin is S-nitrosylated.BIND15105460 
UBE2G1E217K | UBC7 | UBE2Gubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)-HPRD,BioGRID11439185 
UBE2J1CGI-76 | HSPC153 | HSPC205 | HSU93243 | MGC12555 | NCUBE1 | Ubc6pubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)Affinity Capture-WesternBioGRID11439185 
UBE2L3E2-F1 | L-UBC | UBCH7 | UbcM4ubiquitin-conjugating enzyme E2L 3-HPRD,BioGRID11078524 |11278816 
UBE2L6MGC40331 | RIG-B | UBCH8ubiquitin-conjugating enzyme E2L 6-HPRD,BioGRID11078524 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 13898All SZGR genes in this pathway
KEGG_PARKINSONS_DISEASE 13378All SZGR genes in this pathway
BIOCARTA_PARKIN_PATHWAY 138All SZGR genes in this pathway
PID_ALPHA_SYNUCLEIN_PATHWAY 3325All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 251156All SZGR genes in this pathway
REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION 212129All SZGR genes in this pathway
ODONNELL_METASTASIS_UP 8258All SZGR genes in this pathway
TCGA_GLIOBLASTOMA_COPY_NUMBER_DN 3121All SZGR genes in this pathway
LIN_MELANOMA_COPY_NUMBER_DN 4134All SZGR genes in this pathway
CAMPS_COLON_CANCER_COPY_NUMBER_UP 9245All SZGR genes in this pathway
ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN 940425All SZGR genes in this pathway
TAVAZOIE_METASTASIS 10868All SZGR genes in this pathway


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