Gene Page: PARK2

Summary ?
GeneID5071
SymbolPARK2
SynonymsAR-JP|LPRS2|PDJ|PRKN
Descriptionparkin RBR E3 ubiquitin protein ligase
ReferenceMIM:602544|HGNC:HGNC:8607|Ensembl:ENSG00000185345|HPRD:03967|Vega:OTTHUMG00000015970
Gene typeprotein-coding
Map location6q25.2-q27
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophrenias,schizotypalClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 1.0504 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg037427246161838997PARK24.901E-40.3720.047DMG:Wockner_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI11590439 |12364339 |16352719 
|17097639 
GO:0004842ubiquitin-protein ligase activityIDA17097639 
GO:0016874ligase activityIEA-
GO:0016881acid-amino acid ligase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007417central nervous system developmentTASBrain (GO term level: 6)9560156 
GO:0006464protein modification processIEA-
GO:0042787protein ubiquitination during ubiquitin-dependent protein catabolic processIDA17097639 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005794Golgi apparatusIDA17097639 
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-
GO:0048471perinuclear region of cytoplasmIDA17097639 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BAG5BAG-5BCL2-associated athanogene 5BAG5 interacts with parkin.BIND15603737 
CAMK2ACAMKA | KIAA0968calcium/calmodulin-dependent protein kinase II alphaAffinity Capture-WesternBioGRID11679592 
CASKCAGH39 | CMG | FLJ22219 | FLJ31914 | LIN2 | MICPCH | TNRC8calcium/calmodulin-dependent serine protein kinase (MAGUK family)-HPRD,BioGRID11679592 
CASP1ICE | IL1BC | P45caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)-HPRD12692130 
CCNA1-cyclin A1Affinity Capture-WesternBioGRID12628165 
CCNE1CCNEcyclin E1Affinity Capture-WesternBioGRID12628165 
CUL1MGC149834 | MGC149835cullin 1Affinity Capture-Western
Reconstituted Complex		BioGRID12628165 
DLG4FLJ97752 | FLJ98574 | PSD95 | SAP90discs, large homolog 4 (Drosophila)Affinity Capture-WesternBioGRID11679592 
FBXW7AGO | CDC4 | DKFZp686F23254 | FBW6 | FBW7 | FBX30 | FBXO30 | FBXW6 | FLJ16457 | SEL-10 | SEL10F-box and WD repeat domain containing 7-HPRD,BioGRID12628165 
GPR37EDNRBL | PAELR | hET(B)R-LPG protein-coupled receptor 37 (endothelin receptor type B-like)-HPRD,BioGRID11439185 |12150907 
GRIN2BMGC142178 | MGC142180 | NMDAR2B | NR2B | hNR3glutamate receptor, ionotropic, N-methyl D-aspartate 2B-HPRD,BioGRID11679592 
HOMER1HOMER | HOMER1A | HOMER1B | HOMER1C | SYN47 | Ves-1homer homolog 1 (Drosophila)Affinity Capture-WesternBioGRID11679592 
JTV1AIMP2 | P38 | PRO0992JTV1 gene-HPRD,BioGRID12783850 
NDUFA4L2FLJ26118 | NUOMSNADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2Two-hybridBioGRID16169070 
PAFAH1B2-platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 30kDaTwo-hybridBioGRID16169070 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)Two-hybridBioGRID16169070 
RAD1HRAD1 | REC1RAD1 homolog (S. pombe)Two-hybridBioGRID16169070 
RGS2G0S8regulator of G-protein signaling 2, 24kDaTwo-hybridBioGRID16169070 
SEPT4ARTS | BRADEION | CE5B3 | H5 | MART | PNUTL2 | SEP4 | hCDCREL-2 | hucep-7septin 4-HPRD14559152 
SEPT5CDCREL | CDCREL-1 | CDCREL1 | H5 | PNUTL1septin 5-HPRD,BioGRID11078524 
SNCAMGC110988 | NACP | PARK1 | PARK4 | PD1synuclein, alpha (non A4 component of amyloid precursor)-HPRD,BioGRID11588587 
SNCAIPMGC39814 | SYPH1synuclein, alpha interacting protein-HPRD,BioGRID11590439 
SNCAIPMGC39814 | SYPH1synuclein, alpha interacting proteinSynphilin-1 is ubiquitinated by Parkin.BIND15105460 
SNCAIPMGC39814 | SYPH1synuclein, alpha interacting proteinSynphilin interacts with parkin.BIND15603737 
SYT11DKFZp781D015 | KIAA0080 | MGC10881 | MGC17226 | SYT12synaptotagmin XI-HPRD,BioGRID12925569 
TRIP1316E1BPthyroid hormone receptor interactor 13Two-hybridBioGRID16189514 
UBBFLJ25987 | MGC8385ubiquitin BParkin is S-nitrosylated.BIND15105460 
UBE2G1E217K | UBC7 | UBE2Gubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)-HPRD,BioGRID11439185 
UBE2J1CGI-76 | HSPC153 | HSPC205 | HSU93243 | MGC12555 | NCUBE1 | Ubc6pubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)Affinity Capture-WesternBioGRID11439185 
UBE2L3E2-F1 | L-UBC | UBCH7 | UbcM4ubiquitin-conjugating enzyme E2L 3-HPRD,BioGRID11078524 |11278816 
UBE2L6MGC40331 | RIG-B | UBCH8ubiquitin-conjugating enzyme E2L 6-HPRD,BioGRID11078524 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG UBIQUITIN MEDIATED PROTEOLYSIS 13898All SZGR 2.0 genes in this pathway
KEGG PARKINSONS DISEASE 13378All SZGR 2.0 genes in this pathway
BIOCARTA PARKIN PATHWAY 138All SZGR 2.0 genes in this pathway
PID ALPHA SYNUCLEIN PATHWAY 3325All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 251156All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 212129All SZGR 2.0 genes in this pathway
ODONNELL METASTASIS UP 8258All SZGR 2.0 genes in this pathway
TCGA GLIOBLASTOMA COPY NUMBER DN 3121All SZGR 2.0 genes in this pathway
LIN MELANOMA COPY NUMBER DN 4134All SZGR 2.0 genes in this pathway
CAMPS COLON CANCER COPY NUMBER UP 9245All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN 940425All SZGR 2.0 genes in this pathway
TAVAZOIE METASTASIS 10868All SZGR 2.0 genes in this pathway