Gene Page: PDK2
Summary ?
| GeneID | 5164 |
| Symbol | PDK2 |
| Synonyms | PDHK2|PDKII |
| Description | pyruvate dehydrogenase kinase 2 |
| Reference | MIM:602525|HGNC:HGNC:8810|Ensembl:ENSG00000005882|HPRD:03955|Vega:OTTHUMG00000161948 |
| Gene type | protein-coding |
| Map location | 17q21.33 |
| Pascal p-value | 0.313 |
| Sherlock p-value | 0.038 |
| Fetal beta | -1.099 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.1 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| HBM | 0.78 | 0.68 |
| PPBP | 0.77 | 0.73 |
| HBG1 | 0.76 | 0.71 |
| SLC4A1 | 0.75 | 0.74 |
| ALAS2 | 0.75 | 0.77 |
| ERAF | 0.74 | 0.76 |
| EPB42 | 0.72 | 0.73 |
| HEMGN | 0.71 | 0.71 |
| HBA1 | 0.70 | 0.71 |
| DPEP1 | 0.70 | 0.72 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| C5orf53 | -0.47 | -0.67 |
| FBXO2 | -0.45 | -0.64 |
| CCNI2 | -0.45 | -0.66 |
| HLA-F | -0.44 | -0.61 |
| CA4 | -0.44 | -0.63 |
| ASPHD1 | -0.43 | -0.61 |
| PTGDS | -0.43 | -0.61 |
| BCL2L2 | -0.42 | -0.61 |
| SPARCL1 | -0.42 | -0.62 |
| CSRP1 | -0.42 | -0.59 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0000155 | two-component sensor activity | IEA | - | |
| GO:0005515 | protein binding | IEA | - | |
| GO:0005524 | ATP binding | IEA | - | |
| GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity | TAS | 7499431 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006006 | glucose metabolic process | TAS | 7499431 | |
| GO:0005975 | carbohydrate metabolic process | IEA | - | |
| GO:0007165 | signal transduction | IEA | - | |
| GO:0016310 | phosphorylation | IEA | - | |
| GO:0018106 | peptidyl-histidine phosphorylation | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005634 | nucleus | IDA | 18029348 | |
| GO:0005730 | nucleolus | IDA | 18029348 | |
| GO:0005739 | mitochondrion | IEA | - | |
| GO:0005759 | mitochondrial matrix | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| BIOCARTA MTOR PATHWAY | 23 | 15 | All SZGR 2.0 genes in this pathway |
| BIOCARTA PTEN PATHWAY | 18 | 14 | All SZGR 2.0 genes in this pathway |
| BIOCARTA EIF4 PATHWAY | 24 | 19 | All SZGR 2.0 genes in this pathway |
| BIOCARTA IGF1MTOR PATHWAY | 20 | 14 | All SZGR 2.0 genes in this pathway |
| REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE | 48 | 32 | All SZGR 2.0 genes in this pathway |
| REACTOME TCA CYCLE AND RESPIRATORY ELECTRON TRANSPORT | 141 | 85 | All SZGR 2.0 genes in this pathway |
| REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | 13 | 9 | All SZGR 2.0 genes in this pathway |
| REACTOME PYRUVATE METABOLISM | 19 | 14 | All SZGR 2.0 genes in this pathway |
| PARENT MTOR SIGNALING UP | 567 | 375 | All SZGR 2.0 genes in this pathway |
| DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP | 368 | 234 | All SZGR 2.0 genes in this pathway |
| LIU CMYB TARGETS UP | 165 | 106 | All SZGR 2.0 genes in this pathway |
| DOANE RESPONSE TO ANDROGEN UP | 184 | 125 | All SZGR 2.0 genes in this pathway |
| BIDUS METASTASIS DN | 161 | 93 | All SZGR 2.0 genes in this pathway |
| RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN | 805 | 505 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN DN | 1781 | 1082 | All SZGR 2.0 genes in this pathway |
| GAUSSMANN MLL AF4 FUSION TARGETS G UP | 238 | 135 | All SZGR 2.0 genes in this pathway |
| LOPEZ MBD TARGETS | 957 | 597 | All SZGR 2.0 genes in this pathway |
| BENPORATH MYC MAX TARGETS | 775 | 494 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON | 335 | 181 | All SZGR 2.0 genes in this pathway |
| ASTON MAJOR DEPRESSIVE DISORDER DN | 160 | 110 | All SZGR 2.0 genes in this pathway |
| WONG IFNA2 RESISTANCE DN | 34 | 20 | All SZGR 2.0 genes in this pathway |
| PENG RAPAMYCIN RESPONSE UP | 203 | 130 | All SZGR 2.0 genes in this pathway |
| DAIRKEE CANCER PRONE RESPONSE E2 | 28 | 21 | All SZGR 2.0 genes in this pathway |
| WEST ADRENOCORTICAL TUMOR DN | 546 | 362 | All SZGR 2.0 genes in this pathway |
| CHANG CORE SERUM RESPONSE DN | 209 | 137 | All SZGR 2.0 genes in this pathway |
| AGUIRRE PANCREATIC CANCER COPY NUMBER UP | 298 | 174 | All SZGR 2.0 genes in this pathway |
| SHEDDEN LUNG CANCER GOOD SURVIVAL A5 | 70 | 32 | All SZGR 2.0 genes in this pathway |
| ZHANG TLX TARGETS 60HR UP | 293 | 203 | All SZGR 2.0 genes in this pathway |
| HAN SATB1 TARGETS UP | 395 | 249 | All SZGR 2.0 genes in this pathway |
| MONTERO THYROID CANCER POOR SURVIVAL DN | 11 | 6 | All SZGR 2.0 genes in this pathway |
| DANG BOUND BY MYC | 1103 | 714 | All SZGR 2.0 genes in this pathway |
| LEE BMP2 TARGETS UP | 745 | 475 | All SZGR 2.0 genes in this pathway |
| KRIEG HYPOXIA NOT VIA KDM3A | 770 | 480 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |