SZGR2

Summary ?

GeneID	5300
Symbol	PIN1
Synonyms	DOD\|UBL5
Description	peptidylprolyl cis/trans isomerase, NIMA-interacting 1
Reference	MIM:601052\|HGNC:HGNC:8988\|Ensembl:ENSG00000127445\|HPRD:03031\|Vega:OTTHUMG00000180388
Gene type	protein-coding
Map location	19p13
Pascal p-value	0.228
Sherlock p-value	0.23
Fetal beta	-1.568
DMG	2 (# studies)
Support	G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL CompositeSet

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Jaffe_2016	Genome-wide DNA methylation analysis	This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05.	2
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	2
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0573

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg04699474	19	9945708	PIN1	2.24E-5	-0.307	0.017	DMG:Wockner_2014
cg22728790	19	9945653	PIN1	1.08E-7	-0.007	2.34E-5	DMG:Jaffe_2016

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
PTPN3	0.87	0.59
PTPN4	0.86	0.81
AKAP2	0.85	0.74
MCF2	0.85	0.62
FAM19A4	0.84	0.33
RORA	0.84	0.47
EPN3	0.84	0.45
RASSF3	0.84	0.49
CHRNA3	0.83	0.53
SLC17A6	0.83	0.69

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
C16orf74	-0.32	-0.53
RGS20	-0.32	-0.48
C1orf61	-0.31	-0.61
CXCL14	-0.31	-0.48
OAF	-0.31	-0.47
CSAG1	-0.30	-0.50
CLDN10	-0.29	-0.47
AF347015.21	-0.29	-0.54
EIF4EBP3	-0.29	-0.53
VAMP5	-0.29	-0.54

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	IEA		-
GO:0005515	protein binding	IPI		11470801
GO:0016853	isomerase activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006457	protein folding	IEA		-
GO:0007049	cell cycle	IEA		-
GO:0007088	regulation of mitosis	TAS		10391244
GO:0042127	regulation of cell proliferation	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005634	nucleus	TAS		8606777

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
BCL2	Bcl-2	B-cell CLL/lymphoma 2	-	HPRD	11988841
BCL2	Bcl-2	B-cell CLL/lymphoma 2	Affinity Capture-Western	BioGRID	11326318
CCNB1	CCNB	cyclin B1	-	HPRD	9499405
CCND1	BCL1 \| D11S287E \| PRAD1 \| U21B31	cyclin D1	PIN1 interacts with Cyclin D1. This interaction was modelled on a demonstrated interaction between human PIN1 and Cyclin D1 from an unspecified species.	BIND	11805292
CDC2	CDC28A \| CDK1 \| DKFZp686L20222 \| MGC111195	cell division cycle 2, G1 to S and G2 to M	-	HPRD	11774038
CDC25C	CDC25	cell division cycle 25 homolog C (S. pombe)	-	HPRD	9482729 \|9499405 \|10037602\|9499405 \|10037602
CDC25C	CDC25	cell division cycle 25 homolog C (S. pombe)	-	HPRD,BioGRID	9499405 \|10037602
CDC27	APC3 \| CDC27Hs \| D0S1430E \| D17S978E \| HNUC	cell division cycle 27 homolog (S. cerevisiae)	-	HPRD,BioGRID	9499405 \|10939594
CDC27	APC3 \| CDC27Hs \| D0S1430E \| D17S978E \| HNUC	cell division cycle 27 homolog (S. cerevisiae)	Pin1 interacts with Cdc27.	BIND	9499405
CDK9	C-2k \| CDC2L4 \| CTK1 \| PITALRE \| TAK	cyclin-dependent kinase 9	-	HPRD	11575923
CSNK2A1	CK2A1 \| CKII	casein kinase 2, alpha 1 polypeptide	-	HPRD,BioGRID	11940573
CSNK2A2	CK2A2 \| CSNK2A1 \| FLJ43934	casein kinase 2, alpha prime polypeptide	-	HPRD,BioGRID	11940573
CSNK2B	CK2B \| CK2N \| CSK2B \| G5A \| MGC138222 \| MGC138224	casein kinase 2, beta polypeptide	-	HPRD	11940573
CTNNB1	CTNNB \| DKFZp686D02253 \| FLJ25606 \| FLJ37923	catenin (cadherin-associated protein), beta 1, 88kDa	-	HPRD,BioGRID	11533658
DAB2	DOC-2 \| DOC2 \| FLJ26626	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	-	HPRD,BioGRID	12881709
DDX24	-	DEAD (Asp-Glu-Ala-Asp) box polypeptide 24	Two-hybrid	BioGRID	16169070
GGA2	FLJ20966 \| KIAA1080 \| VEAR	golgi associated, gamma adaptin ear containing, ARF binding protein 2	Two-hybrid	BioGRID	16189514
GPAA1	GAA1 \| hGAA1	glycosylphosphatidylinositol anchor attachment protein 1 homolog (yeast)	Two-hybrid	BioGRID	16169070
HNRNPC	C1 \| C2 \| HNRNP \| HNRPC \| MGC104306 \| MGC105117 \| MGC117353 \| MGC131677 \| SNRPC	heterogeneous nuclear ribonucleoprotein C (C1/C2)	Two-hybrid	BioGRID	16189514
JUN	AP-1 \| AP1 \| c-Jun	jun oncogene	-	HPRD,BioGRID	11432833
KIF20B	DKFZp434B0435 \| DKFZp434P0810 \| KRMP1 \| MPHOSPH1 \| MPP-1 \| MPP1	kinesin family member 20B	-	HPRD,BioGRID	11470801
KLHL20	KHLHX \| KLEIP \| KLHLX \| RP3-383J4.3	kelch-like 20 (Drosophila)	Two-hybrid	BioGRID	16169070
LEPR	CD295 \| OBR	leptin receptor	Two-hybrid	BioGRID	16169070
MAPT	DDPAC \| FLJ31424 \| FTDP-17 \| MAPTL \| MGC138549 \| MSTD \| MTBT1 \| MTBT2 \| PPND \| TAU	microtubule-associated protein tau	-	HPRD,BioGRID	10391244
MDFI	I-MF \| I-mfa	MyoD family inhibitor	Two-hybrid	BioGRID	16189514
MYT1	C20orf36 \| MTF1 \| MYTI \| PLPB1	myelin transcription factor 1	Affinity Capture-Western Reconstituted Complex	BioGRID	10504341
NFATC2	KIAA0611 \| NFAT1 \| NFATP	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2	-	HPRD,BioGRID	11356192
NONO	NMT55 \| NRB54 \| P54 \| P54NRB	non-POU domain containing, octamer-binding	Two-hybrid	BioGRID	16189514
PKMYT1	DKFZp547K1610 \| FLJ20093 \| MYT1	protein kinase, membrane associated tyrosine/threonine 1	-	HPRD,BioGRID	9499405 \|10504341
PKMYT1	DKFZp547K1610 \| FLJ20093 \| MYT1	protein kinase, membrane associated tyrosine/threonine 1	Pin1 interacts with phosphorylated Myt1.	BIND	10504341
PLK1	PLK \| STPK13	polo-like kinase 1 (Drosophila)	-	HPRD,BioGRID	9499405
PLK1	PLK \| STPK13	polo-like kinase 1 (Drosophila)	Pin1 interacts with PLK1.	BIND	9499405
POLR2A	MGC75453 \| POLR2 \| POLRA \| RPB1 \| RPBh1 \| RPO2 \| RPOL2 \| RpIILS \| hRPB220 \| hsRPB1	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	-	HPRD	10932246
POLR2A	MGC75453 \| POLR2 \| POLRA \| RPB1 \| RPBh1 \| RPO2 \| RPOL2 \| RpIILS \| hRPB220 \| hsRPB1	polymerase (RNA) II (DNA directed) polypeptide A, 220kDa	Affinity Capture-Western	BioGRID	10393805
PTOV1	ACID2 \| DKFZp586I111 \| MGC71475	prostate tumor overexpressed 1	Two-hybrid	BioGRID	16169070
PTPN1	PTP1B	protein tyrosine phosphatase, non-receptor type 1	-	HPRD	9499405
RAB4A	HRES-1/RAB4 \| RAB4	RAB4A, member RAS oncogene family	-	HPRD,BioGRID	10888662
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1	Raf-1 interacts with Pin1. This interaction was modelled on a demonstrated interaction between human Raf-1 and Pin1 from monkey and unspecified species.	BIND	15664191
RAI1	DKFZp434A139 \| KIAA1820 \| MGC12824 \| SMCR \| SMS	retinoic acid induced 1	Two-hybrid	BioGRID	16189514
RBBP8	CTIP \| RIM	retinoblastoma binding protein 8	Two-hybrid	BioGRID	16189514
RBPMS	HERMES	RNA binding protein with multiple splicing	Two-hybrid	BioGRID	16189514
SFRS12	DKFZp564B176 \| MGC133045 \| SRrp508 \| SRrp86	splicing factor, arginine/serine-rich 12	-	HPRD	14559993
SOCS3	ATOD4 \| CIS3 \| Cish3 \| MGC71791 \| SOCS-3 \| SSI-3 \| SSI3	suppressor of cytokine signaling 3	Two-hybrid	BioGRID	16169070
SUPT5H	FLJ34157 \| SPT5 \| SPT5H	suppressor of Ty 5 homolog (S. cerevisiae)	-	HPRD,BioGRID	11575923
TOP2A	TOP2 \| TP2A	topoisomerase (DNA) II alpha 170kDa	-	HPRD,BioGRID	11940573
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	-	HPRD,BioGRID	12388558 \|12397362
TP73	P73	tumor protein p73	Pin1 interacts with phosphorylated p73-alpha	BIND	15175157
TP73	P73	tumor protein p73	Pin1 interacts with p73-beta.	BIND	15175157
TRAF2	MGC:45012 \| TRAP \| TRAP3	TNF receptor-associated factor 2	Two-hybrid	BioGRID	16189514
TSC22D4	THG-1 \| THG1	TSC22 domain family, member 4	Two-hybrid	BioGRID	16189514
VHL	HRCA1 \| RCA1 \| VHL1	von Hippel-Lindau tumor suppressor	Affinity Capture-MS	BioGRID	17353931
WEE1	DKFZp686I18166 \| FLJ16446 \| WEE1A \| WEE1hu	WEE1 homolog (S. pombe)	Affinity Capture-Western Far Western	BioGRID	9499405
ZCCHC10	FLJ20094	zinc finger, CCHC domain containing 10	Two-hybrid	BioGRID	16169070
ZMIZ2	DKFZp761I2123 \| KIAA1886 \| ZIMP7 \| hZIMP7	zinc finger, MIZ-type containing 2	Two-hybrid	BioGRID	16189514

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG RIG I LIKE RECEPTOR SIGNALING PATHWAY	71	51	All SZGR 2.0 genes in this pathway
BIOCARTA MPR PATHWAY	34	28	All SZGR 2.0 genes in this pathway
ST WNT BETA CATENIN PATHWAY	34	28	All SZGR 2.0 genes in this pathway
PID P73PATHWAY	79	59	All SZGR 2.0 genes in this pathway
PID MYC PATHWAY	25	22	All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY	129	103	All SZGR 2.0 genes in this pathway
PID P53 REGULATION PATHWAY	59	50	All SZGR 2.0 genes in this pathway
REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	66	45	All SZGR 2.0 genes in this pathway
REACTOME INTERFERON SIGNALING	159	116	All SZGR 2.0 genes in this pathway
REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	31	19	All SZGR 2.0 genes in this pathway
REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS	73	57	All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM	279	178	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	270	204	All SZGR 2.0 genes in this pathway
DOANE RESPONSE TO ANDROGEN DN	241	146	All SZGR 2.0 genes in this pathway
SENESE HDAC1 TARGETS DN	260	143	All SZGR 2.0 genes in this pathway
BREUHAHN GROWTH FACTOR SIGNALING IN LIVER CANCER	22	19	All SZGR 2.0 genes in this pathway
DAIRKEE TERT TARGETS UP	380	213	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP	479	299	All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE DN	121	79	All SZGR 2.0 genes in this pathway
MACLACHLAN BRCA1 TARGETS DN	16	12	All SZGR 2.0 genes in this pathway
NATSUME RESPONSE TO INTERFERON BETA DN	52	33	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 UP	428	266	All SZGR 2.0 genes in this pathway
BILD E2F3 ONCOGENIC SIGNATURE	246	153	All SZGR 2.0 genes in this pathway
ZHANG BREAST CANCER PROGENITORS UP	425	253	All SZGR 2.0 genes in this pathway
MATZUK SPERMATOGONIA	24	17	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP	756	494	All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP	682	440	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS DURATION CORR DN	146	90	All SZGR 2.0 genes in this pathway
KASLER HDAC7 TARGETS 1 UP	194	133	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-200bc/429	111	117	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: PIN1