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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: LRP1B

Summary

GeneID

53353

Symbol

LRP1B

Synonyms

LRP-DIT|LRPDIT

Description

low density lipoprotein-related protein 1B (deleted in tumors)

Locus tag

Gene type

protein-coding

Map location

2q21.2

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_I

genome scan meta-analysis

Psr: 0.023

GSMA_IIA

genome scan meta-analysis (All samples)

Psr: 0.02395

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005041

low-density lipoprotein receptor activity

IEA

GO:0004872

receptor activity

IEA

GO:0005509

calcium ion binding

IEA

GO:0005515

protein binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006898

receptor-mediated endocytosis

TAS

10766186

GO:0015031

protein transport

TAS

10766186

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005624

membrane fraction

IEA

GO:0016020

membrane

IEA

GO:0016021

integral to membrane

IEA

Interactions

Shown by Network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
APP	AAA \| ABETA \| ABPP \| AD1 \| APPI \| CTFgamma \| CVAP \| PN2	amyloid beta (A4) precursor protein	-	HPRD	15126508
LRPAP1	A2MRAP \| A2RAP \| HBP44 \| MGC138272 \| MRAP \| RAP	low density lipoprotein receptor-related protein associated protein 1	-	HPRD	11384978
PLAT	DKFZp686I03148 \| T-PA \| TPA	plasminogen activator, tissue	-	HPRD	11384978
PLAUR	CD87 \| UPAR \| URKR	plasminogen activator, urokinase receptor	-	HPRD	11384978 \|12194987
SERPINE1	PAI \| PAI-1 \| PAI1 \| PLANH1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	-	HPRD	11384978

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
DELYS_THYROID_CANCER_DN	232	154	All SZGR genes in this pathway
ROVERSI_GLIOMA_COPY_NUMBER_DN	54	37	All SZGR genes in this pathway
SILIGAN_BOUND_BY_EWS_FLT1_FUSION	47	34	All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_DN	193	112	All SZGR genes in this pathway
DING_LUNG_CANCER_MUTATED_SIGNIFICANTLY	26	22	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN	1237	837	All SZGR genes in this pathway
ULE_SPLICING_VIA_NOVA2	43	38	All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_DN	314	188	All SZGR genes in this pathway
SMID_BREAST_CANCER_RELAPSE_IN_BONE_UP	97	61	All SZGR genes in this pathway
BOQUEST_STEM_CELL_UP	260	174	All SZGR genes in this pathway
BOQUEST_STEM_CELL_CULTURED_VS_FRESH_UP	425	298	All SZGR genes in this pathway
TAYLOR_METHYLATED_IN_ACUTE_LYMPHOBLASTIC_LEUKEMIA	77	52	All SZGR genes in this pathway
DING_LUNG_CANCER_BY_MUTATION_RATE	20	18	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-103/107	231	237	m8	hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
miR-103/107	231	237	m8	hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-130/301	207	213	1A	hsa-miR-130a^brain	CAGUGCAAUGUUAAAAGGGCAU
				hsa-miR-301	CAGUGCAAUAGUAUUGUCAAAGC
				hsa-miR-130b^brain	CAGUGCAAUGAUGAAAGGGCAU
				hsa-miR-454-3p	UAGUGCAAUAUUGCUUAUAGGGUUU
miR-142-5p	1711	1718	1A,m8	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-142-5p	1711	1718	1A,m8	hsa-miR-142-5p	CAUAAAGUAGAAAGCACUAC
miR-15/16/195/424/497	232	238	m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-155	1447	1454	1A,m8	hsa-miR-155	UUAAUGCUAAUCGUGAUAGGGG
miR-183	1524	1530	1A	hsa-miR-183	UAUGGCACUGGUAGAAUUCACUG
miR-196	1505	1512	1A,m8	hsa-miR-196a	UAGGUAGUUUCAUGUUGUUGG
miR-196	1505	1512	1A,m8	hsa-miR-196b	UAGGUAGUUUCCUGUUGUUGG
miR-200bc/429	66	73	1A,m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
				hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-214	234	240	1A	hsa-miR-214^brain	ACAGCAGGCACAGACAGGCAG
miR-330	524	531	1A,m8	hsa-miR-330^brain	GCAAAGCACACGGCCUGCAGAGA
miR-361	1353	1359	m8	hsa-miR-361^brain	UUAUCAGAAUCUCCAGGGGUAC
miR-369-3p	68	75	1A,m8	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-374	69	75	m8	hsa-miR-374	UUAUAAUACAACCUGAUAAGUG
miR-493-5p	1441	1447	1A	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-494	1686	1692	m8	hsa-miR-494^brain	UGAAACAUACACGGGAAACCUCUU
miR-495	258	264	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-543	1586	1592	1A	hsa-miR-543	AAACAUUCGCGGUGCACUUCU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.