SZGR2

Summary ?

GeneID	54329
Symbol	GPR85
Synonyms	SREB\|SREB2
Description	G protein-coupled receptor 85
Reference	MIM:605188\|HGNC:HGNC:4536\|Ensembl:ENSG00000164604\|HPRD:05543\|Vega:OTTHUMG00000156933
Gene type	protein-coding
Map location	7q31
Pascal p-value	0.342
Fetal beta	2.488
Support	G2Cdb.humanPSD G2Cdb.humanPSP

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0004872	receptor activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007186	G-protein coupled receptor protein signaling pathway	IEA		-
GO:0007165	signal transduction	TAS		10833454
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0016021	integral to membrane	IEA		-
GO:0005886	plasma membrane	IEA		-

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
ODONNELL TFRC TARGETS UP	456	228	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN	911	527	All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN	1011	592	All SZGR 2.0 genes in this pathway
ASGHARZADEH NEUROBLASTOMA POOR SURVIVAL DN	46	30	All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN	841	431	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B	549	316	All SZGR 2.0 genes in this pathway
GUILLAUMOND KLF10 TARGETS UP	51	39	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-1/206	557	563	1A	hsa-miR-1	UGGAAUGUAAAGAAGUAUGUA
				hsa-miR-206^SZ	UGGAAUGUAAGGAAGUGUGUGG
				hsa-miR-613	AGGAAUGUUCCUUCUUUGCC
miR-101	478	485	1A,m8	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-124.1	816	823	1A,m8	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	816	822	1A	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	816	822	1A	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-135	1978	1984	m8	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	1978	1984	m8	hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-137	2076	2082	1A	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-144	479	485	1A	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-153	1940	1946	1A	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-155	1539	1545	m8	hsa-miR-155	UUAAUGCUAAUCGUGAUAGGGG
miR-182	1316	1323	1A,m8	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-186	1272	1279	1A,m8	hsa-miR-186	CAAAGAAUUCUCCUUUUGGGCUU
miR-203.1	426	433	1A,m8	hsa-miR-203	UGAAAUGUUUAGGACCACUAG
miR-214	181	188	1A,m8	hsa-miR-214^brain	ACAGCAGGCACAGACAGGCAG
miR-216	993	999	m8	hsa-miR-216	UAAUCUCAGCUGGCAACUGUG
miR-218	1407	1414	1A,m8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-25/32/92/363/367	138	144	1A	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-29	277	283	1A	hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU
miR-34/449	226	232	m8	hsa-miR-34a^brain	UGGCAGUGUCUUAGCUGGUUGUU
				hsa-miR-34c	AGGCAGUGUAGUUAGCUGAUUGC
				hsa-miR-449	UGGCAGUGUAUUGUUAGCUGGU
				hsa-miR-449b	AGGCAGUGUAUUGUUAGCUGGC
miR-369-3p	670	676	m8	hsa-miR-369-3p	AAUAAUACAUGGUUGAUCUUU
miR-377	1289	1296	1A,m8	hsa-miR-377	AUCACACAAAGGCAACUUUUGU
miR-409-3p	1170	1176	1A	hsa-miR-409-3p	CGAAUGUUGCUCGGUGAACCCCU
miR-448	1939	1946	1A,m8	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU
miR-505	385	391	m8	hsa-miR-505	GUCAACACUUGCUGGUUUCCUC
miR-544	798	804	m8	hsa-miR-544	AUUCUGCAUUUUUAGCAAGU
miR-9	2021	2027	m8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA
miR-96	1317	1323	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: GPR85