Gene Page: TTC12
Summary ?
| GeneID | 54970 |
| Symbol | TTC12 |
| Synonyms | TPARM |
| Description | tetratricopeptide repeat domain 12 |
| Reference | MIM:610732|HGNC:HGNC:23700|Ensembl:ENSG00000149292|HPRD:15577|Vega:OTTHUMG00000142832 |
| Gene type | protein-coding |
| Map location | 11q23.2 |
| Pascal p-value | 3.336E-5 |
| DMG | 1 (# studies) |
| eGene | Anterior cingulate cortex BA24 Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Nucleus accumbens basal ganglia Putamen basal ganglia |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Wockner_2014 | Genome-wide DNA methylation analysis | This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). | 1 |
| GSMA_I | Genome scan meta-analysis | Psr: 0.006 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg14892281 | 11 | 113185247 | TTC12 | 1.792E-4 | -0.225 | 0.034 | DMG:Wockner_2014 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs869549 | 11 | 113195611 | TTC12 | ENSG00000149292.12 | 1.649E-6 | 0 | 10360 | gtex_brain_ba24 |
| rs10502172 | 11 | 113199146 | TTC12 | ENSG00000149292.12 | 5.716E-12 | 0 | 13895 | gtex_brain_ba24 |
| rs2303380 | 11 | 113200709 | TTC12 | ENSG00000149292.12 | 1.14E-6 | 0 | 15458 | gtex_brain_ba24 |
| rs10891535 | 11 | 113201280 | TTC12 | ENSG00000149292.12 | 5.716E-12 | 0 | 16029 | gtex_brain_ba24 |
| rs11214577 | 11 | 113204266 | TTC12 | ENSG00000149292.12 | 5.716E-12 | 0 | 19015 | gtex_brain_ba24 |
| rs35126602 | 11 | 113205178 | TTC12 | ENSG00000149292.12 | 5.716E-12 | 0 | 19927 | gtex_brain_ba24 |
| rs1893695 | 11 | 113206085 | TTC12 | ENSG00000149292.12 | 5.716E-12 | 0 | 20834 | gtex_brain_ba24 |
| rs1893696 | 11 | 113206275 | TTC12 | ENSG00000149292.12 | 1.051E-6 | 0 | 21024 | gtex_brain_ba24 |
| rs2155462 | 11 | 113206799 | TTC12 | ENSG00000149292.12 | 5.716E-12 | 0 | 21548 | gtex_brain_ba24 |
| rs7114433 | 11 | 113208098 | TTC12 | ENSG00000149292.12 | 1.023E-6 | 0 | 22847 | gtex_brain_ba24 |
| rs11214579 | 11 | 113208186 | TTC12 | ENSG00000149292.12 | 1.14E-6 | 0 | 22935 | gtex_brain_ba24 |
| rs12282356 | 11 | 113208382 | TTC12 | ENSG00000149292.12 | 1.022E-6 | 0 | 23131 | gtex_brain_ba24 |
| rs10891536 | 11 | 113209428 | TTC12 | ENSG00000149292.12 | 5.716E-12 | 0 | 24177 | gtex_brain_ba24 |
| rs10891537 | 11 | 113211370 | TTC12 | ENSG00000149292.12 | 5.716E-12 | 0 | 26119 | gtex_brain_ba24 |
| rs11214582 | 11 | 113218050 | TTC12 | ENSG00000149292.12 | 2.3E-11 | 0 | 32799 | gtex_brain_ba24 |
| rs10891538 | 11 | 113224017 | TTC12 | ENSG00000149292.12 | 5.716E-12 | 0 | 38766 | gtex_brain_ba24 |
| rs11214583 | 11 | 113224404 | TTC12 | ENSG00000149292.12 | 2.3E-11 | 0 | 39153 | gtex_brain_ba24 |
| rs11493880 | 11 | 113225144 | TTC12 | ENSG00000149292.12 | 5.716E-12 | 0 | 39893 | gtex_brain_ba24 |
| rs11214585 | 11 | 113227723 | TTC12 | ENSG00000149292.12 | 2.335E-11 | 0 | 42472 | gtex_brain_ba24 |
| rs7939992 | 11 | 113229665 | TTC12 | ENSG00000149292.12 | 2.3E-11 | 0 | 44414 | gtex_brain_ba24 |
| rs4438071 | 11 | 113231614 | TTC12 | ENSG00000149292.12 | 9.535E-13 | 0 | 46363 | gtex_brain_ba24 |
| rs4370966 | 11 | 113231691 | TTC12 | ENSG00000149292.12 | 2.787E-13 | 0 | 46440 | gtex_brain_ba24 |
| rs11214587 | 11 | 113232422 | TTC12 | ENSG00000149292.12 | 9.647E-13 | 0 | 47171 | gtex_brain_ba24 |
| rs7115082 | 11 | 113232703 | TTC12 | ENSG00000149292.12 | 4.335E-7 | 0 | 47452 | gtex_brain_ba24 |
| rs2298490 | 11 | 113233059 | TTC12 | ENSG00000149292.12 | 1.452E-7 | 0 | 47808 | gtex_brain_ba24 |
| rs719802 | 11 | 113234679 | TTC12 | ENSG00000149292.12 | 3.089E-7 | 0 | 49428 | gtex_brain_ba24 |
| rs10789942 | 11 | 113236199 | TTC12 | ENSG00000149292.12 | 3.634E-9 | 0 | 50948 | gtex_brain_ba24 |
| rs10891539 | 11 | 113236492 | TTC12 | ENSG00000149292.12 | 3.634E-9 | 0 | 51241 | gtex_brain_ba24 |
| rs200576273 | 11 | 113238572 | TTC12 | ENSG00000149292.12 | 2.709E-7 | 0 | 53321 | gtex_brain_ba24 |
| rs55708748 | 11 | 113238573 | TTC12 | ENSG00000149292.12 | 2.97E-7 | 0 | 53322 | gtex_brain_ba24 |
| rs10891540 | 11 | 113239082 | TTC12 | ENSG00000149292.12 | 3.475E-9 | 0 | 53831 | gtex_brain_ba24 |
| rs12804573 | 11 | 113241726 | TTC12 | ENSG00000149292.12 | 6.898E-9 | 0 | 56475 | gtex_brain_ba24 |
| rs12805699 | 11 | 113241810 | TTC12 | ENSG00000149292.12 | 6.893E-9 | 0 | 56559 | gtex_brain_ba24 |
| rs1078 | 11 | 113241877 | TTC12 | ENSG00000149292.12 | 6.891E-9 | 0 | 56626 | gtex_brain_ba24 |
| rs2155463 | 11 | 113242301 | TTC12 | ENSG00000149292.12 | 3.389E-9 | 0 | 57050 | gtex_brain_ba24 |
| rs2186799 | 11 | 113242533 | TTC12 | ENSG00000149292.12 | 3.456E-9 | 0 | 57282 | gtex_brain_ba24 |
| rs2186800 | 11 | 113242860 | TTC12 | ENSG00000149292.12 | 6.153E-9 | 0 | 57609 | gtex_brain_ba24 |
| rs11214589 | 11 | 113245048 | TTC12 | ENSG00000149292.12 | 3.497E-8 | 0 | 59797 | gtex_brain_ba24 |
| rs754672 | 11 | 113249136 | TTC12 | ENSG00000149292.12 | 6.154E-8 | 0 | 63885 | gtex_brain_ba24 |
| rs7116782 | 11 | 113250938 | TTC12 | ENSG00000149292.12 | 1.236E-7 | 0 | 65687 | gtex_brain_ba24 |
| rs7107223 | 11 | 113255574 | TTC12 | ENSG00000149292.12 | 1.242E-7 | 0 | 70323 | gtex_brain_ba24 |
| rs10891544 | 11 | 113256152 | TTC12 | ENSG00000149292.12 | 6.154E-8 | 0 | 70901 | gtex_brain_ba24 |
| rs877137 | 11 | 113256330 | TTC12 | ENSG00000149292.12 | 6.154E-8 | 0 | 71079 | gtex_brain_ba24 |
| rs11214594 | 11 | 113259332 | TTC12 | ENSG00000149292.12 | 1.284E-7 | 0 | 74081 | gtex_brain_ba24 |
| rs11214595 | 11 | 113259658 | TTC12 | ENSG00000149292.12 | 1.297E-7 | 0 | 74407 | gtex_brain_ba24 |
| rs17600713 | 11 | 113259947 | TTC12 | ENSG00000149292.12 | 1.311E-7 | 0 | 74696 | gtex_brain_ba24 |
| rs34601878 | 11 | 113260898 | TTC12 | ENSG00000149292.12 | 1.368E-7 | 0 | 75647 | gtex_brain_ba24 |
| rs12360992 | 11 | 113262900 | TTC12 | ENSG00000149292.12 | 1.765E-7 | 0 | 77649 | gtex_brain_ba24 |
| rs11214596 | 11 | 113264511 | TTC12 | ENSG00000149292.12 | 1.849E-7 | 0 | 79260 | gtex_brain_ba24 |
| rs35023999 | 11 | 113266411 | TTC12 | ENSG00000149292.12 | 7.155E-8 | 0 | 81160 | gtex_brain_ba24 |
| rs10891547 | 11 | 113267218 | TTC12 | ENSG00000149292.12 | 8.181E-8 | 0 | 81967 | gtex_brain_ba24 |
| rs10891548 | 11 | 113267259 | TTC12 | ENSG00000149292.12 | 8.224E-8 | 0 | 82008 | gtex_brain_ba24 |
| rs11604671 | 11 | 113268059 | TTC12 | ENSG00000149292.12 | 9.217E-8 | 0 | 82808 | gtex_brain_ba24 |
| rs2734849 | 11 | 113270160 | TTC12 | ENSG00000149292.12 | 1.085E-7 | 0 | 84909 | gtex_brain_ba24 |
| rs3897583 | 11 | 113160199 | TTC12 | ENSG00000149292.12 | 2.994E-10 | 0 | -25052 | gtex_brain_putamen_basal |
| rs3885072 | 11 | 113167420 | TTC12 | ENSG00000149292.12 | 1.016E-8 | 0 | -17831 | gtex_brain_putamen_basal |
| rs1943623 | 11 | 113174339 | TTC12 | ENSG00000149292.12 | 1.016E-8 | 0 | -10912 | gtex_brain_putamen_basal |
| rs7118188 | 11 | 113178597 | TTC12 | ENSG00000149292.12 | 1.015E-8 | 0 | -6654 | gtex_brain_putamen_basal |
| rs2236709 | 11 | 113186776 | TTC12 | ENSG00000149292.12 | 1.015E-8 | 0 | 1525 | gtex_brain_putamen_basal |
| rs2303380 | 11 | 113200709 | TTC12 | ENSG00000149292.12 | 5.641E-7 | 0 | 15458 | gtex_brain_putamen_basal |
| rs1893696 | 11 | 113206275 | TTC12 | ENSG00000149292.12 | 2.393E-7 | 0 | 21024 | gtex_brain_putamen_basal |
| rs7114433 | 11 | 113208098 | TTC12 | ENSG00000149292.12 | 9.47E-8 | 0 | 22847 | gtex_brain_putamen_basal |
| rs11214579 | 11 | 113208186 | TTC12 | ENSG00000149292.12 | 3.992E-7 | 0 | 22935 | gtex_brain_putamen_basal |
| rs12282356 | 11 | 113208382 | TTC12 | ENSG00000149292.12 | 9.444E-8 | 0 | 23131 | gtex_brain_putamen_basal |
| rs4438071 | 11 | 113231614 | TTC12 | ENSG00000149292.12 | 4.167E-7 | 0 | 46363 | gtex_brain_putamen_basal |
| rs4370966 | 11 | 113231691 | TTC12 | ENSG00000149292.12 | 4.01E-7 | 0 | 46440 | gtex_brain_putamen_basal |
| rs11214587 | 11 | 113232422 | TTC12 | ENSG00000149292.12 | 2.974E-7 | 0 | 47171 | gtex_brain_putamen_basal |
| rs7115082 | 11 | 113232703 | TTC12 | ENSG00000149292.12 | 3.673E-8 | 0 | 47452 | gtex_brain_putamen_basal |
| rs2298490 | 11 | 113233059 | TTC12 | ENSG00000149292.12 | 2.901E-8 | 0 | 47808 | gtex_brain_putamen_basal |
| rs719802 | 11 | 113234679 | TTC12 | ENSG00000149292.12 | 4.372E-6 | 0 | 49428 | gtex_brain_putamen_basal |
| rs2298489 | 11 | 113235419 | TTC12 | ENSG00000149292.12 | 4.222E-6 | 0 | 50168 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0005488 | binding | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| SENGUPTA NASOPHARYNGEAL CARCINOMA DN | 349 | 157 | All SZGR 2.0 genes in this pathway |
| DOANE RESPONSE TO ANDROGEN UP | 184 | 125 | All SZGR 2.0 genes in this pathway |
| DODD NASOPHARYNGEAL CARCINOMA UP | 1821 | 933 | All SZGR 2.0 genes in this pathway |
| RODRIGUES THYROID CARCINOMA ANAPLASTIC DN | 537 | 339 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 2 | 473 | 224 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER RELAPSE IN BONE UP | 97 | 61 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER RELAPSE IN LUNG DN | 37 | 22 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER LUMINAL B UP | 172 | 109 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER BASAL DN | 701 | 446 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN ES ICP WITH H3K4ME3 | 718 | 401 | All SZGR 2.0 genes in this pathway |
| NOUSHMEHR GBM SILENCED BY METHYLATION | 50 | 32 | All SZGR 2.0 genes in this pathway |