Gene Page: PRKAA1

Summary
GeneID  5562
Symbol  PRKAA1
Synonyms  AMPK|AMPKa1|MGC33776|MGC57364
Description  protein kinase, AMP-activated, alpha 1 catalytic subunit
See related  HGNC:9376|MIM:602739|Ensembl:ENSG00000132356|HPRD:04115|
Locus tag  -
Gene type  protein-coding
Map location  5p12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.3086 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
NCAM20.890.87
WASL0.880.91
BAG40.870.88
SGIP10.860.88
CLOCK0.860.90
WDR70.860.87
DNAJB140.850.88
USP120.850.88
PREPL0.850.91
PCTK20.850.89
Top 10 negatively co-expressed genes
AL022328.1-0.46-0.51
RP9P-0.44-0.49
AC098691.2-0.42-0.44
RAB34-0.41-0.45
IRF7-0.41-0.48
C16orf79-0.41-0.41
NUDT8-0.40-0.42
C1orf61-0.40-0.47
BCL7C-0.40-0.43
IL32-0.39-0.36
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingIEA-
GO:0005515protein bindingIPI18403135 
GO:0005524ATP bindingIEA-
GO:0004674protein serine/threonine kinase activityIEA-
GO:0004691cAMP-dependent protein kinase activityNAS8557660 
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000187activation of MAPK activityNAS11546797 
GO:0001666response to hypoxiaNAS8557660 
GO:0006468protein amino acid phosphorylationIEA-
GO:0007165signal transductionTAS8557660 
GO:0006633fatty acid biosynthetic processIEA-
GO:0045768positive regulation of anti-apoptosisNAS11165240 
GO:0045542positive regulation of cholesterol biosynthetic processNAS8557660 
GO:0046318negative regulation of glucosylceramide biosynthetic processNAS11165240 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005622intracellularIC8557660 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CAB39CGI-66 | FLJ22682 | MO25calcium binding protein 39-HPRD8910387 
CFTRABC35 | ABCC7 | CF | CFTR/MRP | MRP7 | TNR-CFTR | dJ760C5.1cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)-HPRD,BioGRID10862786 
FNIP1DKFZp686E18167 | DKFZp781P0215 | KIAA1961 | MGC667folliculin interacting protein 1Affinity Capture-Western
Biochemical Activity
Reconstituted Complex		BioGRID17028174 
FRAP1FLJ44809 | FRAP | FRAP2 | MTOR | RAFT1 | RAPT1FK506 binding protein 12-rapamycin associated protein 1Protein-peptideBioGRID14970221 
TOMM34HTOM34P | TOM34 | URCC3translocase of outer mitochondrial membrane 34-HPRD11913976 
TSC2FLJ43106 | LAM | TSC4tuberous sclerosis 2Affinity Capture-Western
Reconstituted Complex		BioGRID14651849 |15261145 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_REGULATION_OF_AUTOPHAGY 3530All SZGR genes in this pathway
KEGG_MTOR_SIGNALING_PATHWAY 5240All SZGR genes in this pathway
KEGG_INSULIN_SIGNALING_PATHWAY 137103All SZGR genes in this pathway
KEGG_ADIPOCYTOKINE_SIGNALING_PATHWAY 6757All SZGR genes in this pathway
KEGG_HYPERTROPHIC_CARDIOMYOPATHY_HCM 8565All SZGR genes in this pathway
BIOCARTA_CHREBP2_PATHWAY 4235All SZGR genes in this pathway
BIOCARTA_LEPTIN_PATHWAY 1111All SZGR genes in this pathway
PID_LKB1_PATHWAY 4737All SZGR genes in this pathway
PID_VEGFR1_2_PATHWAY 6957All SZGR genes in this pathway
REACTOME_ACTIVATED_AMPK_STIMULATES_FATTY_ACID_OXIDATION_IN_MUSCLE 1916All SZGR genes in this pathway
REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 8764All SZGR genes in this pathway
REACTOME_REGULATION_OF_AMPK_ACTIVITY_VIA_LKB1 1513All SZGR genes in this pathway
REACTOME_ENERGY_DEPENDENT_REGULATION_OF_MTOR_BY_LKB1_AMPK 1815All SZGR genes in this pathway
REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK 109All SZGR genes in this pathway
REACTOME_PKB_MEDIATED_EVENTS 2923All SZGR genes in this pathway
REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 10872All SZGR genes in this pathway
REACTOME_PI3K_CASCADE 7151All SZGR genes in this pathway
IGARASHI_ATF4_TARGETS_DN 9065All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP 633376All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL 326213All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_BASAL 330217All SZGR genes in this pathway
KOYAMA_SEMA3B_TARGETS_DN 411249All SZGR genes in this pathway
SAKAI_CHRONIC_HEPATITIS_VS_LIVER_CANCER_DN 3624All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP 314201All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL 254164All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
DE_YY1_TARGETS_DN 9264All SZGR genes in this pathway
FIRESTEIN_PROLIFERATION 175125All SZGR genes in this pathway
HOFMANN_MYELODYSPLASTIC_SYNDROM_HIGH_RISK_DN 2013All SZGR genes in this pathway
HOFMANN_MYELODYSPLASTIC_SYNDROM_RISK_DN 2312All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_DN 448282All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-101277727841A,m8hsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-130/30124782484m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-144277827841Ahsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-148/152206920761A,m8hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-153271327191Ahsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-191231301A,m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-30-3p27442750m8hsa-miR-30a-3pCUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3pCUUUCAGUCGGAUGUUUACAGC
miR-33265026571A,m8hsa-miR-33GUGCAUUGUAGUUGCAUUG
hsa-miR-33bGUGCAUUGCUGUUGCAUUGCA
miR-448271327191Ahsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-496281828241Ahsa-miR-496AUUACAUGGCCAAUCUC
miR-539284728541A,m8hsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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