Gene Page: NGLY1

Summary ?
GeneID55768
SymbolNGLY1
SynonymsCDDG|CDG1V|PNG1|PNGase
DescriptionN-glycanase 1
ReferenceMIM:610661|HGNC:HGNC:17646|Ensembl:ENSG00000151092|HPRD:10118|Vega:OTTHUMG00000155600
Gene typeprotein-coding
Map location3p24.2
Pascal p-value0.029
Sherlock p-value0.231

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
GSMA_IGenome scan meta-analysisPsr: 0.006 
ExpressionMeta-analysis of gene expressionP value: 1.638 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
CTNND20.810.74
TMEM167B0.810.76
NDRG10.810.77
GPD1L0.800.76
HERC30.800.74
NNT0.800.75
FAM124A0.790.74
MARS20.790.77
RP1-21O18.10.790.77
WASF10.790.70
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.21-0.62-0.62
C11orf67-0.58-0.58
MT-CO2-0.58-0.58
AF347015.8-0.55-0.55
NOSTRIN-0.55-0.53
GNG11-0.55-0.52
AC098691.2-0.54-0.55
AF347015.27-0.54-0.55
AF347015.31-0.54-0.54
AL138743.2-0.54-0.52

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000224peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activityIEA-
GO:0005515protein bindingIPI15358861 
GO:0016787hydrolase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006516glycoprotein catabolic processIDA15358861 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIDA15358861 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
ZHONG RESPONSE TO AZACITIDINE AND TSA DN 7038All SZGR 2.0 genes in this pathway
LIU VMYB TARGETS UP 12778All SZGR 2.0 genes in this pathway
WANG RESPONSE TO ANDROGEN UP 2921All SZGR 2.0 genes in this pathway
WANG RESPONSE TO FORSKOLIN UP 2317All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER DN 800473All SZGR 2.0 genes in this pathway
INGRAM SHH TARGETS UP 12779All SZGR 2.0 genes in this pathway
HADDAD B LYMPHOCYTE PROGENITOR 293193All SZGR 2.0 genes in this pathway
ALCALAY AML BY NPM1 LOCALIZATION DN 184132All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS DN 314188All SZGR 2.0 genes in this pathway
PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION DN 4938All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229713All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973570All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN DN 249165All SZGR 2.0 genes in this pathway
CAIRO LIVER DEVELOPMENT DN 222141All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841431All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN 19721213All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 36HR 2923All SZGR 2.0 genes in this pathway
NABA ECM REGULATORS 238125All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED 753411All SZGR 2.0 genes in this pathway
NABA MATRISOME 1028559All SZGR 2.0 genes in this pathway