Gene Page: PCDHB11

Summary ?
GeneID56125
SymbolPCDHB11
SynonymsME2|PCDH-BETA11
Descriptionprotocadherin beta 11
ReferenceMIM:606337|HGNC:HGNC:8682|HPRD:06955|
Gene typeprotein-coding
Map location5q31
Pascal p-value0.054
Sherlock p-value0.526
Fetal beta1.78

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IGenome scan meta-analysisPsr: 0.0032 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
RHOT20.890.88
PPAN-P2RY110.890.89
CDK90.870.87
ZGPAT0.860.87
SH2B10.860.88
C19orf60.860.86
WDR240.850.83
ACAP30.850.87
TUBGCP60.850.88
PPAN0.850.85
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.21-0.68-0.69
AF347015.31-0.65-0.62
AF347015.27-0.63-0.62
MT-CO2-0.62-0.60
AF347015.8-0.61-0.59
GNG11-0.59-0.63
MT-CYB-0.59-0.57
AF347015.33-0.58-0.56
MT-ATP8-0.58-0.65
NOSTRIN-0.58-0.56

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005509calcium ion bindingIEA-
GO:0005515protein bindingNAS11322959 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007416synaptogenesisTASSynap (GO term level: 6)12231349 
GO:0007268synaptic transmissionTASneuron, Synap, Neurotransmitter (GO term level: 6)12231349 
GO:0007155cell adhesionTAS10380929 
GO:0007156homophilic cell adhesionIEA-
GO:0016339calcium-dependent cell-cell adhesionNAS9182820 |11322959 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneNAS9182820 
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS10380929 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552347All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770415All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS F UP 185119All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS UP 292168All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP 244165All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
MIKKELSEN IPS HCP WITH H3 UNMETHYLATED 8050All SZGR 2.0 genes in this pathway
MIKKELSEN ES HCP WITH H3K27ME3 4130All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3 UNMETHYLATED 228119All SZGR 2.0 genes in this pathway
FIGUEROA AML METHYLATION CLUSTER 3 UP 17097All SZGR 2.0 genes in this pathway