SZGR2

Summary ?

GeneID	57478
Symbol	USP31
Synonyms	-
Description	ubiquitin specific peptidase 31
Reference	HGNC:HGNC:20060\|Ensembl:ENSG00000103404\|HPRD:15634\|Vega:OTTHUMG00000094793
Gene type	protein-coding
Map location	16p12.2
Pascal p-value	0.011
Fetal beta	0.628
eGene	Meta

Gene in Data Sources

Gene set name	Method of gene set	Description
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS
GSMA_IIE	Genome scan meta-analysis (European-ancestry samples)	Psr: 0.01775

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0004221	ubiquitin thiolesterase activity	IEA		-
GO:0008234	cysteine-type peptidase activity	IEA		-
GO:0008233	peptidase activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006511	ubiquitin-dependent protein catabolic process	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005737	cytoplasm	IDA		18029348

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
LIU SOX4 TARGETS UP	137	94	All SZGR 2.0 genes in this pathway
TURASHVILI BREAST DUCTAL CARCINOMA VS DUCTAL NORMAL DN	198	110	All SZGR 2.0 genes in this pathway
LIU TARGETS OF VMYB VS CMYB DN	43	30	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP	722	443	All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY NO BLOOD UP	222	139	All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP	487	303	All SZGR 2.0 genes in this pathway
CHANG IMMORTALIZED BY HPV31 UP	84	55	All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP	566	371	All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 6HR UP	229	149	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A	770	480	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-101	4515	4521	1A	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-134	796	802	m8	hsa-miR-134^brain	UGUGACUGGUUGACCAGAGGG
miR-135	210	216	1A	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
miR-135	210	216	1A	hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-144	4514	4521	1A,m8	hsa-miR-144	UACAGUAUAGAUGAUGUACUAG
miR-145	239	246	1A,m8	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-15/16/195/424/497	1689	1696	1A,m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-17-5p/20/93.mr/106/519.d	510	516	m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
				hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-218	3898	3904	m8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-23	5632	5639	1A,m8	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	5632	5639	1A,m8	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-24*	215	221	1A	hsa-miR-189	GUGCCUACUGAGCUGAUAUCAGU
miR-29	6026	6032	1A	hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU
miR-323	5632	5638	1A	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-34/449	5128	5135	1A,m8	hsa-miR-34a^brain	UGGCAGUGUCUUAGCUGGUUGUU
				hsa-miR-34c	AGGCAGUGUAGUUAGCUGAUUGC
				hsa-miR-449	UGGCAGUGUAUUGUUAGCUGGU
				hsa-miR-449b	AGGCAGUGUAUUGUUAGCUGGC
miR-378	2462	2468	1A	hsa-miR-378	CUCCUGACUCCAGGUCCUGUGU
miR-494	561	567	m8	hsa-miR-494^brain	UGAAACAUACACGGGAAACCUCUU
miR-503	1690	1696	1A	hsa-miR-503	UAGCAGCGGGAACAGUUCUGCAG
miR-505	4489	4495	1A	hsa-miR-505	GUCAACACUUGCUGGUUUCCUC
miR-539	564	570	1A	hsa-miR-539	GGAGAAAUUAUCCUUGGUGUGU
miR-9	65	71	m8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: USP31