Gene Page: MKL2

Summary
GeneID  57496
Symbol  MKL2
Synonyms  DKFZp686J1745|FLJ31823|FLJ45623|MRTF-B|NPD001
Description  MKL/myocardin-like 2
See related  HGNC:29819|MIM:609463|Ensembl:ENSG00000186260|HPRD:17577|
Locus tag  -
Gene type  protein-coding
Map location  16p13.12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01775 
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003676nucleic acid bindingIEA-
GO:0003713transcription coactivator activityIDA14565952 
GO:0042802identical protein bindingIPI14565952 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007519skeletal muscle developmentIEAneuron (GO term level: 8)-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
GO:0007275multicellular organismal developmentIEA-
GO:0030154cell differentiationIEA-
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA14565952 
GO:0045844positive regulation of striated muscle developmentIDA14565952 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIC14565952 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
MKL1BSAC | MAL | MRTF-Amegakaryoblastic leukemia (translocation) 1-HPRD,BioGRID14565952 
MKL2DKFZp686J1745 | FLJ31823 | FLJ45623 | MRTF-B | NPD001MKL/myocardin-like 2Affinity Capture-WesternBioGRID14565952 
SRFMCM1serum response factor (c-fos serum response element-binding transcription factor)-HPRD,BioGRID12397177 |14565952 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
ZHOU_INFLAMMATORY_RESPONSE_LIVE_DN 384220All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_DN 536332All SZGR genes in this pathway
ZHOU_INFLAMMATORY_RESPONSE_FIMA_DN 284156All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
HAHTOLA_MYCOSIS_FUNGOIDES_SKIN_UP 177113All SZGR genes in this pathway
FARMER_BREAST_CANCER_BASAL_VS_LULMINAL 330215All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP 414287All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP 424268All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_SUBOPTIMAL_DEBULKING 510309All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_DN 210128All SZGR genes in this pathway
MIKKELSEN_NPC_ICP_WITH_H3K4ME3 445257All SZGR genes in this pathway
STAMBOLSKY_BOUND_BY_MUTATED_TP53 1812All SZGR genes in this pathway


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