SZGR2

Summary ?

GeneID	599
Symbol	BCL2L2
Synonyms	BCL-W\|BCL2-L-2\|BCLW\|PPP1R51
Description	BCL2 like 2
Reference	MIM:601931\|HGNC:HGNC:995\|Ensembl:ENSG00000129473\|HPRD:03569\|Vega:OTTHUMG00000028738
Gene type	protein-coding
Map location	14q11.2-q12
Sherlock p-value	0.198
DEG p-value	DEG:Sanders_2014:DS1_p=0.178:DS1_beta=0.004880:DS2_p=3.17e-05:DS2_beta=0.207:DS2_FDR=1.69e-03
Fetal beta	-2.754

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
DEG:Sanders_2013	Microarray	Whole-genome gene expression profiles using microarrays on lymphoblastoid cell lines (LCLs) from 413 cases and 446 controls.
GSMA_I	Genome scan meta-analysis	Psr: 0.047

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
BCAM	0.60	0.72
PERP	0.59	0.68
ZFP36	0.59	0.49
SSH3	0.55	0.63
ICAM1	0.54	0.58
LASS1	0.54	0.61
SLCO4A1	0.52	0.57
FOXF1	0.50	0.51
APOLD1	0.49	0.36
MOBKL2C	0.49	0.56

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AKT3	-0.34	-0.45
ZNF33B	-0.33	-0.45
PHF14	-0.33	-0.52
NLGN1	-0.33	-0.40
ROBO2	-0.32	-0.44
EPHA7	-0.32	-0.44
DOK6	-0.32	-0.41
ENY2	-0.32	-0.40
TRDMT1	-0.32	-0.39
FANCM	-0.32	-0.42

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005515	protein binding	IPI		15694340 \|16697956
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007283	spermatogenesis	TAS		8761287
GO:0006916	anti-apoptosis	TAS		9500547
GO:0042981	regulation of apoptosis	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005737	cytoplasm	NAS		-
GO:0005739	mitochondrion	IEA		-
GO:0016020	membrane	IEA		-
GO:0031966	mitochondrial membrane	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
BAD	BBC2 \| BCL2L8	BCL2-associated agonist of cell death	-	HPRD,BioGRID	11483855 \|12115603
BAD	BBC2 \| BCL2L8	BCL2-associated agonist of cell death	Bad interacts with Bcl-w.	BIND	15694340
BAK1	BAK \| BAK-LIKE \| BCL2L7 \| CDN1 \| MGC117255 \| MGC3887	BCL2-antagonist/killer 1	Affinity Capture-Western	BioGRID	10381646
BAX	BCL2L4	BCL2-associated X protein	Affinity Capture-Western	BioGRID	10381646
BBC3	JFY1 \| PUMA	BCL2 binding component 3	Puma interacts with Bcl-w.	BIND	15694340
BCL2L11	BAM \| BIM \| BIM-alpha6 \| BIM-beta6 \| BIM-beta7 \| BOD \| BimEL \| BimL	BCL2-like 11 (apoptosis facilitator)	Bim interacts with Bcl-w.	BIND	15694340
BCL2L11	BAM \| BIM \| BIM-alpha6 \| BIM-beta6 \| BIM-beta7 \| BOD \| BimEL \| BimL	BCL2-like 11 (apoptosis facilitator)	Two-hybrid	BioGRID	9731710
BID	FP497 \| MGC15319 \| MGC42355	BH3 interacting domain death agonist	Protein-peptide	BioGRID	15694340
BID	FP497 \| MGC15319 \| MGC42355	BH3 interacting domain death agonist	Bid interacts with Bcl-w.	BIND	15694340
BIK	BIP1 \| BP4 \| NBK	BCL2-interacting killer (apoptosis-inducing)	Affinity Capture-Western	BioGRID	10381646
BIK	BIP1 \| BP4 \| NBK	BCL2-interacting killer (apoptosis-inducing)	Bik interacts with Bcl-w.	BIND	15694340
BMF	FLJ00065	Bcl2 modifying factor	Bmf interacts with Bcl-w. This interaction was modelled on a demonstrated interaction between mouse Bmf and human Bcl-w.	BIND	15694340
BMF	FLJ00065	Bcl2 modifying factor	-	HPRD,BioGRID	11546872
HRK	DP5 \| HARAKIRI	harakiri, BCL2 interacting protein (contains only BH3 domain)	Hrk interacts with Bcl-w.	BIND	15694340
HRK	DP5 \| HARAKIRI	harakiri, BCL2 interacting protein (contains only BH3 domain)	Protein-peptide	BioGRID	15694340
PMAIP1	APR \| NOXA	phorbol-12-myristate-13-acetate-induced protein 1	Protein-peptide	BioGRID	15694340
PPP1CA	MGC15877 \| MGC1674 \| PP-1A \| PPP1A	protein phosphatase 1, catalytic subunit, alpha isoform	Affinity Capture-Western Reconstituted Complex	BioGRID	12115603

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
PID P53 DOWNSTREAM PATHWAY	137	94	All SZGR 2.0 genes in this pathway
LIU SOX4 TARGETS DN	309	191	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP	552	347	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION DN	234	147	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION DN	84	54	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP	1142	669	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN	770	415	All SZGR 2.0 genes in this pathway
GALLUZZI PREVENT MITOCHONDIAL PERMEABILIZATION	22	16	All SZGR 2.0 genes in this pathway
AMUNDSON RESPONSE TO ARSENITE	217	143	All SZGR 2.0 genes in this pathway
KREPPEL CD99 TARGETS DN	8	5	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN	584	395	All SZGR 2.0 genes in this pathway
TENEDINI MEGAKARYOCYTE MARKERS	66	48	All SZGR 2.0 genes in this pathway
NATSUME RESPONSE TO INTERFERON BETA UP	71	49	All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP	314	201	All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE DN	123	76	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY GAMMA AND UV RADIATION	88	65	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE UP	226	164	All SZGR 2.0 genes in this pathway
EHLERS ANEUPLOIDY UP	41	29	All SZGR 2.0 genes in this pathway
MATZUK EMBRYONIC GERM CELL	19	16	All SZGR 2.0 genes in this pathway
MATZUK MALE REPRODUCTION SERTOLI	28	23	All SZGR 2.0 genes in this pathway
MATZUK SPERMATOCYTE	72	55	All SZGR 2.0 genes in this pathway
MATZUK SPERMATID DIFFERENTIATION	37	26	All SZGR 2.0 genes in this pathway
BONCI TARGETS OF MIR15A AND MIR16 1	91	75	All SZGR 2.0 genes in this pathway
WINTER HYPOXIA METAGENE	242	168	All SZGR 2.0 genes in this pathway
BEIER GLIOMA STEM CELL DN	66	42	All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN MYELOMA VS MATURE B LYMPHOCYTE	101	76	All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP	442	263	All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION	422	277	All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3	718	401	All SZGR 2.0 genes in this pathway
MIKKELSEN NPC ICP WITH H3K4ME3	445	257	All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP	682	440	All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY	1725	838	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-10	1902	1908	1A	hsa-miR-10a	UACCCUGUAGAUCCGAAUUUGUG
miR-10	1902	1908	1A	hsa-miR-10b	UACCCUGUAGAACCGAAUUUGU
miR-103/107	1364	1370	1A	hsa-miR-103^brain	AGCAGCAUUGUACAGGGCUAUGA
miR-103/107	1364	1370	1A	hsa-miR-107^brain	AGCAGCAUUGUACAGGGCUAUCA
miR-122	1331	1337	1A	hsa-miR-122a	UGGAGUGUGACAAUGGUGUUUGU
miR-133	1544	1551	1A,m8	hsa-miR-133a	UUGGUCCCCUUCAACCAGCUGU
miR-133	1544	1551	1A,m8	hsa-miR-133b	UUGGUCCCCUUCAACCAGCUA
miR-140	1954	1960	m8	hsa-miR-140^brain	AGUGGUUUUACCCUAUGGUAG
miR-148/152	1450	1456	1A	hsa-miR-148a	UCAGUGCACUACAGAACUUUGU
				hsa-miR-152^brain	UCAGUGCAUGACAGAACUUGGG
				hsa-miR-148b	UCAGUGCAUCACAGAACUUUGU
miR-149	1350	1357	1A,m8	hsa-miR-149^brain	UCUGGCUCCGUGUCUUCACUCC
miR-15/16/195/424/497	1390	1396	m8	hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
				hsa-miR-15a^brain	UAGCAGCACAUAAUGGUUUGUG
				hsa-miR-16^brain	UAGCAGCACGUAAAUAUUGGCG
				hsa-miR-15b^brain	UAGCAGCACAUCAUGGUUUACA
				hsa-miR-195^SZ	UAGCAGCACAGAAAUAUUGGC
				hsa-miR-424	CAGCAGCAAUUCAUGUUUUGAA
				hsa-miR-497	CAGCAGCACACUGUGGUUUGU
miR-17-5p/20/93.mr/106/519.d	1599	1605	m8	hsa-miR-17-5p	CAAAGUGCUUACAGUGCAGGUAGU
				hsa-miR-20a^brain	UAAAGUGCUUAUAGUGCAGGUAG
				hsa-miR-106a	AAAAGUGCUUACAGUGCAGGUAGC
				hsa-miR-106b^SZ	UAAAGUGCUGACAGUGCAGAU
				hsa-miR-20b^SZ	CAAAGUGCUCAUAGUGCAGGUAG
				hsa-miR-519d	CAAAGUGCCUCCCUUUAGAGUGU
miR-214	1935	1941	1A	hsa-miR-214^brain	ACAGCAGGCACAGACAGGCAG
miR-24	1348	1355	1A,m8	hsa-miR-24^SZ	UGGCUCAGUUCAGCAGGAACAG
miR-29	1379	1385	1A	hsa-miR-29a^SZ	UAGCACCAUCUGAAAUCGGUU
				hsa-miR-29b^SZ	UAGCACCAUUUGAAAUCAGUGUU
				hsa-miR-29c^SZ	UAGCACCAUUUGAAAUCGGU
miR-30-3p	1938	1944	1A	hsa-miR-30a-3p	CUUUCAGUCGGAUGUUUGCAGC
miR-30-3p	1938	1944	1A	hsa-miR-30e-3p	CUUUCAGUCGGAUGUUUACAGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: BCL2L2