Gene Page: HCN2

Summary
GeneID  610
Symbol  HCN2
Synonyms  BCNG-2|BCNG2|HAC-1
Description  hyperpolarization activated cyclic nucleotide-gated potassium channel 2
See related  HGNC:4846|MIM:602781|Ensembl:ENSG00000099822|HPRD:07213|
Locus tag  -
Gene type  protein-coding
Map location  19p13.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
FAM171A10.890.88
ULK10.870.89
SRF0.850.91
AKAP10.840.86
MESDC10.830.84
RAPGEF10.830.89
WDTC10.820.88
RUNDC10.820.86
DAB2IP0.820.88
FAM168B0.820.87
Top 10 negatively co-expressed genes
AF347015.21-0.68-0.76
AF347015.31-0.63-0.67
MT-CO2-0.62-0.66
C1orf54-0.62-0.74
GNG11-0.60-0.67
SYCP3-0.60-0.68
AF347015.8-0.59-0.64
HIGD1B-0.58-0.65
NOSTRIN-0.58-0.63
MYL3-0.57-0.62
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIEA-
GO:0005244voltage-gated ion channel activityIEA-
GO:0005249voltage-gated potassium channel activityIEA-
GO:0005272sodium channel activityIEA-
GO:0030552cAMP bindingIEA-
GO:0030955potassium ion bindingIEA-
GO:0031402sodium ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007267cell-cell signalingTAS9630217 
GO:0006814sodium ion transportIEA-
GO:0006812cation transportTAS10228147 
GO:0006813potassium ion transportIEA-
GO:0006936muscle contractionTAS10228147 
GO:0042391regulation of membrane potentialIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0008076voltage-gated potassium channel complexTAS9630217 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
HCN1BCNG-1 | BCNG1 | HAC-2hyperpolarization activated cyclic nucleotide-gated potassium channel 1-HPRD11133998 |12034718 
Affinity Capture-Western
Two-hybrid		BioGRID12034718 |12928435 
HCN2BCNG-2 | BCNG2 | HAC-1hyperpolarization activated cyclic nucleotide-gated potassium channel 2Two-hybridBioGRID12034718 
HCN4-hyperpolarization activated cyclic nucleotide-gated potassium channel 4Affinity Capture-WesternBioGRID12928435 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_POTASSIUM_CHANNELS 9868All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_UP 240152All SZGR genes in this pathway
MCCLUNG_DELTA_FOSB_TARGETS_8WK 4738All SZGR genes in this pathway
LEIN_OLIGODENDROCYTE_MARKERS 7453All SZGR genes in this pathway
LEIN_PONS_MARKERS 8959All SZGR genes in this pathway
COULOUARN_TEMPORAL_TGFB1_SIGNATURE_DN 13899All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2_AND_H3K27ME3 349234All SZGR genes in this pathway
MIKKELSEN_NPC_HCP_WITH_H3K27ME3 341243All SZGR genes in this pathway
DURAND_STROMA_S_UP 297194All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1356066m8hsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
hsa-miR-135aUAUGGCUUUUUAUUCCUAUGUGA
hsa-miR-135bUAUGGCUUUUCAUUCCUAUGUG
miR-1815805871A,m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-25/32/92/363/3673913981A,m8hsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-95662m8hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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