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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: SCN3A

Summary

GeneID

6328

Symbol

SCN3A

Synonyms

KIAA1356|NAC3|Nav1.3

Description

sodium channel, voltage-gated, type III, alpha subunit

Locus tag

Gene type

protein-coding

Map location

2q24

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GSMA_IIA

genome scan meta-analysis (All samples)

Psr: 0.02395

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

ISG20

0.67

0.74

S100A4

0.66

0.70

HLA-B

0.64

0.75

HLA-F

0.64

0.79

PLA1A

0.62

0.76

GBP2

0.62

0.72

CFB

0.60

0.71

HLA-C

0.60

0.72

HIGD1B

0.57

0.70

C16orf89

0.57

0.70

Top 10 negatively co-expressed genes

BLMH

-0.55

-0.76

ARMCX5

-0.55

-0.76

ZNF23

-0.54

-0.76

CSTF3

-0.53

-0.76

PSPC1

-0.53

-0.74

PPP3CC

-0.53

-0.76

SUPV3L1

-0.53

-0.72

GSTA4

-0.53

-0.78

GNL3

-0.53

-0.74

MARK3

-0.53

-0.75

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005244

voltage-gated ion channel activity

IEA

GO:0005248

voltage-gated sodium channel activity

NAS

9589372

GO:0031402

sodium ion binding

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0006814

sodium ion transport

NAS

9589372

GO:0006811

ion transport

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0001518

voltage-gated sodium channel complex

NAS

GO:0016020

membrane

IEA

GO:0016021

integral to membrane

IEA

Interactions

Shown by Network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
LRP1	A2MR \| APOER \| APR \| CD91 \| FLJ16451 \| IGFBP3R \| LRP \| MGC88725 \| TGFBR5	low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)	Two-hybrid	BioGRID	10827173
LRP2	DBS \| gp330	low density lipoprotein-related protein 2	Two-hybrid	BioGRID	10827173
LRP8	APOER2 \| HSZ75190 \| MCI1	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor	Two-hybrid	BioGRID	10827173

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
DAVICIONI_TARGETS_OF_PAX_FOXO1_FUSIONS_UP	255	177	All SZGR genes in this pathway
HOEBEKE_LYMPHOID_STEM_CELL_UP	95	64	All SZGR genes in this pathway
LEE_NEURAL_CREST_STEM_CELL_UP	146	99	All SZGR genes in this pathway
JAATINEN_HEMATOPOIETIC_STEM_CELL_UP	316	190	All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_F_UP	185	119	All SZGR genes in this pathway
MAHADEVAN_IMATINIB_RESISTANCE_UP	23	15	All SZGR genes in this pathway
HADDAD_B_LYMPHOCYTE_PROGENITOR	293	193	All SZGR genes in this pathway
HADDAD_T_LYMPHOCYTE_AND_NK_PROGENITOR_DN	63	41	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN	1237	837	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_DN	165	106	All SZGR genes in this pathway
ZHENG_IL22_SIGNALING_DN	42	26	All SZGR genes in this pathway
LIN_NPAS4_TARGETS_UP	163	100	All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP	1305	895	All SZGR genes in this pathway
ASGHARZADEH_NEUROBLASTOMA_POOR_SURVIVAL_DN	46	30	All SZGR genes in this pathway
VERHAAK_GLIOBLASTOMA_PRONEURAL	177	132	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-10	178	184	1A	hsa-miR-10a	UACCCUGUAGAUCCGAAUUUGUG
miR-10	178	184	1A	hsa-miR-10b	UACCCUGUAGAACCGAAUUUGU
miR-132/212	99	105	m8	hsa-miR-212^SZ	UAACAGUCUCCAGUCACGGCC
miR-132/212	99	105	m8	hsa-miR-132^brain	UAACAGUCUACAGCCAUGGUCG
miR-145	66	72	m8	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-153	683	689	1A	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-182	90	96	1A	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-183	350	356	1A	hsa-miR-183	UAUGGCACUGGUAGAAUUCACUG
miR-214	227	233	1A	hsa-miR-214^brain	ACAGCAGGCACAGACAGGCAG
miR-223	95	101	m8	hsa-miR-223	UGUCAGUUUGUCAAAUACCCC
miR-24	1977	1983	1A	hsa-miR-24^SZ	UGGCUCAGUUCAGCAGGAACAG
miR-25/32/92/363/367	1824	1830	m8	hsa-miR-25^brain	CAUUGCACUUGUCUCGGUCUGA
				hsa-miR-32	UAUUGCACAUUACUAAGUUGC
				hsa-miR-92	UAUUGCACUUGUCCCGGCCUG
				hsa-miR-367	AAUUGCACUUUAGCAAUGGUGA
				hsa-miR-92b^SZ	UAUUGCACUCGUCCCGGCCUC
miR-30-5p	32	39	1A,m8	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-339	1030	1036	1A	hsa-miR-339	UCCCUGUCCUCCAGGAGCUCA
miR-363	708	714	1A	hsa-miR-363	AUUGCACGGUAUCCAUCUGUAA
miR-379	1593	1599	1A	hsa-miR-379^brain	UGGUAGACUAUGGAACGUA
miR-448	683	689	1A	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU
miR-494	697	703	1A	hsa-miR-494^brain	UGAAACAUACACGGGAAACCUCUU
miR-495	1576	1582	1A	hsa-miR-495^brain	AAACAAACAUGGUGCACUUCUUU
miR-496	1378	1384	1A	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-496	1378	1384	1A	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-96	90	96	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.