Gene Page: SLC22A5
Summary ?
| GeneID | 6584 |
| Symbol | SLC22A5 |
| Synonyms | CDSP|OCTN2 |
| Description | solute carrier family 22 member 5 |
| Reference | MIM:603377|HGNC:HGNC:10969|Ensembl:ENSG00000197375|HPRD:04539|Vega:OTTHUMG00000059634 |
| Gene type | protein-coding |
| Map location | 5q23.3 |
| Pascal p-value | 0.228 |
| Sherlock p-value | 0.84 |
| DEG p-value | DEG:Zhao_2015:p=5.15e-04:q=0.0926 |
| Fetal beta | 0.315 |
| eGene | Caudate basal ganglia Cerebellum Putamen basal ganglia Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DEG:Zhao_2015 | RNA Sequencing analysis | Transcriptome sequencing and genome-wide association analyses reveal lysosomal function and actin cytoskeleton remodeling in schizophrenia and bipolar disorder. | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.0032 | |
| Expression | Meta-analysis of gene expression | P value: 1.629 |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs16829545 | chr2 | 151977407 | SLC22A5 | 6584 | 6.024E-7 | trans | ||
| rs7584986 | chr2 | 184111432 | SLC22A5 | 6584 | 0.11 | trans | ||
| rs1472616 | chr5 | 61026501 | SLC22A5 | 6584 | 0.13 | trans | ||
| rs16955618 | chr15 | 29937543 | SLC22A5 | 6584 | 5.451E-8 | trans | ||
| rs257388 | 5 | 130746524 | SLC22A5 | ENSG00000197375.8 | 1.389E-6 | 0 | -958920 | gtex_brain_putamen_basal |
| rs75544080 | 5 | 130885515 | SLC22A5 | ENSG00000197375.8 | 1.684E-6 | 0 | -819929 | gtex_brain_putamen_basal |
| rs17171380 | 5 | 131020095 | SLC22A5 | ENSG00000197375.8 | 1.302E-6 | 0 | -685349 | gtex_brain_putamen_basal |
| rs76386054 | 5 | 131023158 | SLC22A5 | ENSG00000197375.8 | 1.33E-6 | 0 | -682286 | gtex_brain_putamen_basal |
| rs4705893 | 5 | 131075921 | SLC22A5 | ENSG00000197375.8 | 1.684E-6 | 0 | -629523 | gtex_brain_putamen_basal |
| rs79392931 | 5 | 131285115 | SLC22A5 | ENSG00000197375.8 | 4.907E-7 | 0 | -420329 | gtex_brain_putamen_basal |
| rs17132144 | 5 | 131293738 | SLC22A5 | ENSG00000197375.8 | 4.358E-7 | 0 | -411706 | gtex_brain_putamen_basal |
| rs200173717 | 5 | 131364524 | SLC22A5 | ENSG00000197375.8 | 4.65E-6 | 0 | -340920 | gtex_brain_putamen_basal |
| rs61009979 | 5 | 131364527 | SLC22A5 | ENSG00000197375.8 | 1.304E-6 | 0 | -340917 | gtex_brain_putamen_basal |
| rs17165633 | 5 | 131391390 | SLC22A5 | ENSG00000197375.8 | 2.262E-6 | 0 | -314054 | gtex_brain_putamen_basal |
| rs2073506 | 5 | 131394738 | SLC22A5 | ENSG00000197375.8 | 1.319E-6 | 0 | -310706 | gtex_brain_putamen_basal |
| rs181781 | 5 | 131395115 | SLC22A5 | ENSG00000197375.8 | 1.267E-6 | 0 | -310329 | gtex_brain_putamen_basal |
| rs35334449 | 5 | 131559523 | SLC22A5 | ENSG00000197375.8 | 3.022E-6 | 0 | -145921 | gtex_brain_putamen_basal |
| rs34852689 | 5 | 131566647 | SLC22A5 | ENSG00000197375.8 | 7.259E-7 | 0 | -138797 | gtex_brain_putamen_basal |
| rs35724182 | 5 | 131580301 | SLC22A5 | ENSG00000197375.8 | 1.328E-7 | 0 | -125143 | gtex_brain_putamen_basal |
| rs35719560 | 5 | 131584395 | SLC22A5 | ENSG00000197375.8 | 1.328E-7 | 0 | -121049 | gtex_brain_putamen_basal |
| rs3749753 | 5 | 131587131 | SLC22A5 | ENSG00000197375.8 | 1.392E-7 | 0 | -118313 | gtex_brain_putamen_basal |
| rs68115520 | 5 | 131589692 | SLC22A5 | ENSG00000197375.8 | 1.957E-6 | 0 | -115752 | gtex_brain_putamen_basal |
| rs71583466 | 5 | 131595454 | SLC22A5 | ENSG00000197375.8 | 1.328E-7 | 0 | -109990 | gtex_brain_putamen_basal |
| rs35566767 | 5 | 131606049 | SLC22A5 | ENSG00000197375.8 | 7.069E-7 | 0 | -99395 | gtex_brain_putamen_basal |
| rs2292260 | 5 | 131606936 | SLC22A5 | ENSG00000197375.8 | 4.364E-6 | 0 | -98508 | gtex_brain_putamen_basal |
| rs4877 | 5 | 131607588 | SLC22A5 | ENSG00000197375.8 | 9.214E-7 | 0 | -97856 | gtex_brain_putamen_basal |
| rs6878253 | 5 | 131613293 | SLC22A5 | ENSG00000197375.8 | 4.364E-6 | 0 | -92151 | gtex_brain_putamen_basal |
| rs6878192 | 5 | 131613543 | SLC22A5 | ENSG00000197375.8 | 4.537E-6 | 0 | -91901 | gtex_brain_putamen_basal |
| rs11954518 | 5 | 131614099 | SLC22A5 | ENSG00000197375.8 | 4.364E-6 | 0 | -91345 | gtex_brain_putamen_basal |
| rs7721296 | 5 | 131615966 | SLC22A5 | ENSG00000197375.8 | 2.923E-6 | 0 | -89478 | gtex_brain_putamen_basal |
| rs17693348 | 5 | 131616208 | SLC22A5 | ENSG00000197375.8 | 8.85E-7 | 0 | -89236 | gtex_brain_putamen_basal |
| rs35466090 | 5 | 131622836 | SLC22A5 | ENSG00000197375.8 | 4.852E-7 | 0 | -82608 | gtex_brain_putamen_basal |
| rs35539449 | 5 | 131627985 | SLC22A5 | ENSG00000197375.8 | 1.108E-6 | 0 | -77459 | gtex_brain_putamen_basal |
| rs3761661 | 5 | 131628435 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -77009 | gtex_brain_putamen_basal |
| rs3792876 | 5 | 131637309 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -68135 | gtex_brain_putamen_basal |
| rs13175394 | 5 | 131641206 | SLC22A5 | ENSG00000197375.8 | 2.19E-7 | 0 | -64238 | gtex_brain_putamen_basal |
| rs186970542 | 5 | 131642081 | SLC22A5 | ENSG00000197375.8 | 1.038E-6 | 0 | -63363 | gtex_brain_putamen_basal |
| rs192253397 | 5 | 131642123 | SLC22A5 | ENSG00000197375.8 | 8.33E-8 | 0 | -63321 | gtex_brain_putamen_basal |
| rs71583469 | 5 | 131642650 | SLC22A5 | ENSG00000197375.8 | 4.839E-7 | 0 | -62794 | gtex_brain_putamen_basal |
| rs71583470 | 5 | 131643316 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -62128 | gtex_brain_putamen_basal |
| rs35316456 | 5 | 131643824 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -61620 | gtex_brain_putamen_basal |
| rs3805665 | 5 | 131644718 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -60726 | gtex_brain_putamen_basal |
| rs3792879 | 5 | 131644835 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -60609 | gtex_brain_putamen_basal |
| rs3792880 | 5 | 131644965 | SLC22A5 | ENSG00000197375.8 | 4.839E-7 | 0 | -60479 | gtex_brain_putamen_basal |
| rs3792882 | 5 | 131645111 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -60333 | gtex_brain_putamen_basal |
| rs34695718 | 5 | 131645532 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -59912 | gtex_brain_putamen_basal |
| rs3805666 | 5 | 131646475 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -58969 | gtex_brain_putamen_basal |
| rs3805667 | 5 | 131646516 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -58928 | gtex_brain_putamen_basal |
| rs3805668 | 5 | 131646588 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -58856 | gtex_brain_putamen_basal |
| rs3805669 | 5 | 131646762 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -58682 | gtex_brain_putamen_basal |
| rs13179900 | 5 | 131647590 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -57854 | gtex_brain_putamen_basal |
| rs4646194 | 5 | 131649062 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -56382 | gtex_brain_putamen_basal |
| rs2073838 | 5 | 131649222 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -56222 | gtex_brain_putamen_basal |
| rs2073839 | 5 | 131650245 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -55199 | gtex_brain_putamen_basal |
| rs3792883 | 5 | 131651181 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -54263 | gtex_brain_putamen_basal |
| rs3828673 | 5 | 131651565 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -53879 | gtex_brain_putamen_basal |
| rs3792885 | 5 | 131652248 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -53196 | gtex_brain_putamen_basal |
| rs34757387 | 5 | 131652677 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -52767 | gtex_brain_putamen_basal |
| rs34604423 | 5 | 131653511 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -51933 | gtex_brain_putamen_basal |
| rs57600888 | 5 | 131654053 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -51391 | gtex_brain_putamen_basal |
| rs71583471 | 5 | 131654167 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -51277 | gtex_brain_putamen_basal |
| rs3761659 | 5 | 131657784 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -47660 | gtex_brain_putamen_basal |
| rs3805672 | 5 | 131658974 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -46470 | gtex_brain_putamen_basal |
| rs3805673 | 5 | 131659103 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -46341 | gtex_brain_putamen_basal |
| rs71583474 | 5 | 131661810 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -43634 | gtex_brain_putamen_basal |
| rs77975982 | 5 | 131661993 | SLC22A5 | ENSG00000197375.8 | 2.203E-7 | 0 | -43451 | gtex_brain_putamen_basal |
| rs71583475 | 5 | 131662507 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -42937 | gtex_brain_putamen_basal |
| rs397694380 | 5 | 131667026 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -38418 | gtex_brain_putamen_basal |
| rs2304081 | 5 | 131667548 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -37896 | gtex_brain_putamen_basal |
| rs3805676 | 5 | 131668467 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -36977 | gtex_brain_putamen_basal |
| rs4646200 | 5 | 131671136 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -34308 | gtex_brain_putamen_basal |
| rs67200157 | 5 | 131671867 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -33577 | gtex_brain_putamen_basal |
| rs35497612 | 5 | 131673106 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -32338 | gtex_brain_putamen_basal |
| rs71583476 | 5 | 131673212 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -32232 | gtex_brain_putamen_basal |
| rs141858026 | 5 | 131674596 | SLC22A5 | ENSG00000197375.8 | 2.184E-7 | 0 | -30848 | gtex_brain_putamen_basal |
| rs3805678 | 5 | 131675207 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -30237 | gtex_brain_putamen_basal |
| rs2306772 | 5 | 131675981 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -29463 | gtex_brain_putamen_basal |
| rs13184379 | 5 | 131678145 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -27299 | gtex_brain_putamen_basal |
| rs4646204 | 5 | 131679995 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -25449 | gtex_brain_putamen_basal |
| rs57750646 | 5 | 131680264 | SLC22A5 | ENSG00000197375.8 | 6.755E-7 | 0 | -25180 | gtex_brain_putamen_basal |
| rs35167365 | 5 | 131681744 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -23700 | gtex_brain_putamen_basal |
| rs58389930 | 5 | 131683424 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -22020 | gtex_brain_putamen_basal |
| rs200938253 | 5 | 131683488 | SLC22A5 | ENSG00000197375.8 | 2.181E-7 | 0 | -21956 | gtex_brain_putamen_basal |
| rs111366895 | 5 | 131684147 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -21297 | gtex_brain_putamen_basal |
| rs34689843 | 5 | 131685256 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -20188 | gtex_brain_putamen_basal |
| rs35847227 | 5 | 131685347 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -20097 | gtex_brain_putamen_basal |
| rs71583477 | 5 | 131686040 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -19404 | gtex_brain_putamen_basal |
| rs35948329 | 5 | 131686452 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -18992 | gtex_brain_putamen_basal |
| rs36108085 | 5 | 131686479 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -18965 | gtex_brain_putamen_basal |
| rs34754328 | 5 | 131688074 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -17370 | gtex_brain_putamen_basal |
| rs71583478 | 5 | 131688824 | SLC22A5 | ENSG00000197375.8 | 2.201E-7 | 0 | -16620 | gtex_brain_putamen_basal |
| rs56996855 | 5 | 131689638 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -15806 | gtex_brain_putamen_basal |
| rs111920861 | 5 | 131690649 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -14795 | gtex_brain_putamen_basal |
| rs34034297 | 5 | 131691176 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -14268 | gtex_brain_putamen_basal |
| rs35412807 | 5 | 131692945 | SLC22A5 | ENSG00000197375.8 | 2.18E-7 | 0 | -12499 | gtex_brain_putamen_basal |
| rs34547355 | 5 | 131693114 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -12330 | gtex_brain_putamen_basal |
| rs35834048 | 5 | 131695336 | SLC22A5 | ENSG00000197375.8 | 2.187E-7 | 0 | -10108 | gtex_brain_putamen_basal |
| rs35809179 | 5 | 131695406 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -10038 | gtex_brain_putamen_basal |
| rs147708834 | 5 | 131696192 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -9252 | gtex_brain_putamen_basal |
| rs71583480 | 5 | 131696251 | SLC22A5 | ENSG00000197375.8 | 2.187E-7 | 0 | -9193 | gtex_brain_putamen_basal |
| rs71583481 | 5 | 131696551 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -8893 | gtex_brain_putamen_basal |
| rs71583482 | 5 | 131697941 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -7503 | gtex_brain_putamen_basal |
| rs71583483 | 5 | 131698019 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -7425 | gtex_brain_putamen_basal |
| rs111421603 | 5 | 131701410 | SLC22A5 | ENSG00000197375.8 | 2.32E-7 | 0 | -4034 | gtex_brain_putamen_basal |
| rs397738314 | 5 | 131704407 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -1037 | gtex_brain_putamen_basal |
| rs34786243 | 5 | 131704720 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | -724 | gtex_brain_putamen_basal |
| rs4646298 | 5 | 131705219 | SLC22A5 | ENSG00000197375.8 | 6.131E-8 | 0 | -225 | gtex_brain_putamen_basal |
| rs13180169 | 5 | 131705526 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | 82 | gtex_brain_putamen_basal |
| rs13180186 | 5 | 131705558 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | 114 | gtex_brain_putamen_basal |
| rs13180043 | 5 | 131705587 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | 143 | gtex_brain_putamen_basal |
| rs13180295 | 5 | 131705588 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | 144 | gtex_brain_putamen_basal |
| rs3788987 | 5 | 131706289 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | 845 | gtex_brain_putamen_basal |
| rs3788988 | 5 | 131706371 | SLC22A5 | ENSG00000197375.8 | 3.677E-7 | 0 | 927 | gtex_brain_putamen_basal |
| rs13185655 | 5 | 131706747 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | 1303 | gtex_brain_putamen_basal |
| rs13167994 | 5 | 131706823 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | 1379 | gtex_brain_putamen_basal |
| rs13163451 | 5 | 131709599 | SLC22A5 | ENSG00000197375.8 | 9.231E-7 | 0 | 4155 | gtex_brain_putamen_basal |
| rs34590412 | 5 | 131710027 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | 4583 | gtex_brain_putamen_basal |
| rs4646301 | 5 | 131711100 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | 5656 | gtex_brain_putamen_basal |
| rs4646302 | 5 | 131712482 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | 7038 | gtex_brain_putamen_basal |
| rs34452667 | 5 | 131713555 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | 8111 | gtex_brain_putamen_basal |
| rs2073642 | 5 | 131713774 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | 8330 | gtex_brain_putamen_basal |
| rs4646304 | 5 | 131714778 | SLC22A5 | ENSG00000197375.8 | 2.191E-7 | 0 | 9334 | gtex_brain_putamen_basal |
| rs13187029 | 5 | 131715379 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | 9935 | gtex_brain_putamen_basal |
| rs4646305 | 5 | 131718539 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | 13095 | gtex_brain_putamen_basal |
| rs201158854 | 5 | 131719047 | SLC22A5 | ENSG00000197375.8 | 2.187E-7 | 0 | 13603 | gtex_brain_putamen_basal |
| rs77461733 | 5 | 131719049 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | 13605 | gtex_brain_putamen_basal |
| rs71583484 | 5 | 131719130 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | 13686 | gtex_brain_putamen_basal |
| rs71583485 | 5 | 131719382 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | 13938 | gtex_brain_putamen_basal |
| rs71583486 | 5 | 131719689 | SLC22A5 | ENSG00000197375.8 | 2.183E-7 | 0 | 14245 | gtex_brain_putamen_basal |
| rs13161860 | 5 | 131721860 | SLC22A5 | ENSG00000197375.8 | 2.703E-7 | 0 | 16416 | gtex_brain_putamen_basal |
| rs2073645 | 5 | 131724814 | SLC22A5 | ENSG00000197375.8 | 3.96E-6 | 0 | 19370 | gtex_brain_putamen_basal |
| rs35295663 | 5 | 131727908 | SLC22A5 | ENSG00000197375.8 | 3.542E-6 | 0 | 22464 | gtex_brain_putamen_basal |
| rs13152848 | 5 | 131737646 | SLC22A5 | ENSG00000197375.8 | 3.96E-6 | 0 | 32202 | gtex_brain_putamen_basal |
| rs13179841 | 5 | 131742820 | SLC22A5 | ENSG00000197375.8 | 4.109E-6 | 0 | 37376 | gtex_brain_putamen_basal |
| rs201484464 | 5 | 131752641 | SLC22A5 | ENSG00000197375.8 | 3.247E-6 | 0 | 47197 | gtex_brain_putamen_basal |
| rs35373795 | 5 | 131753824 | SLC22A5 | ENSG00000197375.8 | 3.277E-6 | 0 | 48380 | gtex_brain_putamen_basal |
| rs75472890 | 5 | 131760428 | SLC22A5 | ENSG00000197375.8 | 5.157E-6 | 0 | 54984 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| ZNF689 | 0.93 | 0.95 |
| ZNF574 | 0.93 | 0.94 |
| SMCR7 | 0.93 | 0.92 |
| C17orf100 | 0.93 | 0.93 |
| C7orf13 | 0.93 | 0.94 |
| ZNF835 | 0.93 | 0.95 |
| CHMP7 | 0.93 | 0.94 |
| C14orf4 | 0.93 | 0.95 |
| ZNRF1 | 0.93 | 0.94 |
| ZNF746 | 0.92 | 0.94 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| AF347015.31 | -0.73 | -0.87 |
| MT-CO2 | -0.72 | -0.88 |
| AF347015.33 | -0.72 | -0.87 |
| AF347015.27 | -0.72 | -0.87 |
| MT-CYB | -0.70 | -0.86 |
| AF347015.8 | -0.70 | -0.88 |
| FXYD1 | -0.69 | -0.84 |
| S100B | -0.69 | -0.82 |
| C5orf53 | -0.69 | -0.76 |
| COPZ2 | -0.68 | -0.78 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | - | |
| GO:0005524 | ATP binding | IEA | - | |
| GO:0005215 | transporter activity | IEA | - | |
| GO:0015293 | symporter activity | IEA | - | |
| GO:0015226 | carnitine transporter activity | TAS | 9685390 | |
| GO:0015075 | ion transmembrane transporter activity | IEA | - | |
| GO:0031402 | sodium ion binding | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0006814 | sodium ion transport | IEA | - | |
| GO:0006811 | ion transport | IEA | - | |
| GO:0006810 | transport | IEA | - | |
| GO:0015879 | carnitine transport | TAS | 9685390 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0016021 | integral to membrane | IEA | - | |
| GO:0005886 | plasma membrane | TAS | 9685390 |9916797 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES | 413 | 270 | All SZGR 2.0 genes in this pathway |
| REACTOME SLC MEDIATED TRANSMEMBRANE TRANSPORT | 241 | 157 | All SZGR 2.0 genes in this pathway |
| REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS | 89 | 54 | All SZGR 2.0 genes in this pathway |
| REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | 13 | 9 | All SZGR 2.0 genes in this pathway |
| DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP | 368 | 234 | All SZGR 2.0 genes in this pathway |
| NUYTTEN NIPP1 TARGETS UP | 769 | 437 | All SZGR 2.0 genes in this pathway |
| NUYTTEN EZH2 TARGETS UP | 1037 | 673 | All SZGR 2.0 genes in this pathway |
| FRASOR RESPONSE TO ESTRADIOL UP | 37 | 28 | All SZGR 2.0 genes in this pathway |
| SWEET KRAS TARGETS UP | 84 | 51 | All SZGR 2.0 genes in this pathway |
| LI WILMS TUMOR VS FETAL KIDNEY 1 UP | 182 | 119 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 20HR UP | 240 | 152 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 48HR UP | 180 | 125 | All SZGR 2.0 genes in this pathway |
| KAAB HEART ATRIUM VS VENTRICLE DN | 261 | 183 | All SZGR 2.0 genes in this pathway |
| WENG POR TARGETS GLOBAL DN | 23 | 14 | All SZGR 2.0 genes in this pathway |
| CREIGHTON ENDOCRINE THERAPY RESISTANCE 4 | 307 | 185 | All SZGR 2.0 genes in this pathway |
| GAVIN FOXP3 TARGETS CLUSTER P3 | 160 | 103 | All SZGR 2.0 genes in this pathway |
| MARSON BOUND BY FOXP3 UNSTIMULATED | 1229 | 713 | All SZGR 2.0 genes in this pathway |
| MASSARWEH TAMOXIFEN RESISTANCE DN | 258 | 160 | All SZGR 2.0 genes in this pathway |
| DUTERTRE ESTRADIOL RESPONSE 6HR UP | 229 | 149 | All SZGR 2.0 genes in this pathway |
| DUTERTRE ESTRADIOL RESPONSE 24HR UP | 324 | 193 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |
| BHAT ESR1 TARGETS NOT VIA AKT1 UP | 211 | 131 | All SZGR 2.0 genes in this pathway |
| BHAT ESR1 TARGETS VIA AKT1 UP | 281 | 183 | All SZGR 2.0 genes in this pathway |
| SERVITJA LIVER HNF1A TARGETS UP | 135 | 96 | All SZGR 2.0 genes in this pathway |
| KRIEG HYPOXIA NOT VIA KDM3A | 770 | 480 | All SZGR 2.0 genes in this pathway |
Section VI. microRNA annotation
| miRNA family | Target position | miRNA ID | miRNA seq | ||
|---|---|---|---|---|---|
| UTR start | UTR end | Match method | |||
| miR-124/506 | 1290 | 1296 | m8 | hsa-miR-506 | UAAGGCACCCUUCUGAGUAGA |
| hsa-miR-124brain | UAAGGCACGCGGUGAAUGCC | ||||
| miR-182 | 1039 | 1045 | 1A | hsa-miR-182 | UUUGGCAAUGGUAGAACUCACA |
| miR-96 | 1038 | 1045 | 1A,m8 | hsa-miR-96brain | UUUGGCACUAGCACAUUUUUGC |
- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.