Gene Page: SNAP25

Summary
GeneID  6616
Symbol  SNAP25
Synonyms  FLJ23079|RIC-4|RIC4|SEC9|SNAP|SNAP-25|bA416N4.2|dJ1068F16.2
Description  synaptosomal-associated protein, 25kDa
See related  HGNC:11132|MIM:600322|Ensembl:ENSG00000132639|HPRD:02637|
Locus tag  -
Gene type  protein-coding
Map location  20p12-p11.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.046 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenia, schizophrenias]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 8 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0523 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ARX0.930.84
DLX20.880.82
DLX10.870.77
E2F20.850.70
DLX50.850.76
SPC240.850.62
SP90.840.83
AC018470.30.840.83
CDCA70.840.74
HJURP0.840.67
Top 10 negatively co-expressed genes
C5orf53-0.36-0.65
HLA-F-0.34-0.56
AF347015.31-0.34-0.68
S100B-0.34-0.63
AF347015.27-0.34-0.66
MT-CO2-0.33-0.69
AF347015.33-0.33-0.66
PTGDS-0.33-0.56
CA4-0.33-0.55
TINAGL1-0.33-0.52
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI8692999 |11438518 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007269neurotransmitter secretionNASneuron, axon, Synap, serotonin, Neurotransmitter, dopamine (GO term level: 8)-
GO:0007268synaptic transmissionNASneuron, Synap, Neurotransmitter (GO term level: 6)8760387 
GO:0016081synaptic vesicle docking during exocytosisNASSynap (GO term level: 10)8760387 
GO:0001504neurotransmitter uptakeNASneuron, Cholinergic, Synap, Neurotransmitter, Glial (GO term level: 8)8760387 
GO:0050796regulation of insulin secretionTAS15537656 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0043005neuron projectionISSneuron, axon, neurite, dendrite (GO term level: 5)-
GO:0031201SNARE complexISSneuron, Synap (GO term level: 6)-
GO:0019717synaptosomeIEASynap, Brain (GO term level: 7)-
GO:0030426growth coneISSaxon, dendrite (GO term level: 5)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0016020membraneIEA-
GO:0030054cell junctionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CPLX1CPX-I | CPX1complexin 1Co-crystal Structure
Reconstituted Complex		BioGRID11832227 |12200427 
DNM1DNMdynamin 1-HPRD10373452 
GOSR1GOLIM2 | GOS-28 | GOS28 | GOS28/P28 | GS28 | P28golgi SNAP receptor complex member 1Reconstituted ComplexBioGRID9325254 
HGSHRS | ZFYVE8hepatocyte growth factor-regulated tyrosine kinase substrate-HPRD10825299 |11493665|11493665 
-HPRD11493665 
ITSN1ITSN | MGC134948 | MGC134949 | SH3D1A | SH3P17intersectin 1 (SH3 domain protein)-HPRD,BioGRID10373452 
KCNB1DRK1 | KV2.1 | h-DRK1potassium voltage-gated channel, Shab-related subfamily, member 1-HPRD,BioGRID12403834 
KIF5BKINH | KNS | KNS1 | UKHCkinesin family member 5B-HPRD,BioGRID12475239 
NAPASNAPAN-ethylmaleimide-sensitive factor attachment protein, alphaReconstituted ComplexBioGRID7622514 
PRRT2DKFZp547J199 | FLJ25513proline-rich transmembrane protein 2Two-hybridBioGRID16169070 
SCAMP1SCAMP | SCAMP37secretory carrier membrane protein 1Reconstituted ComplexBioGRID10777571 
SNAPINSNAPAPSNAP-associated protein-HPRD,BioGRID10195194 
SNAP25 interacts with Snapin.BIND15635093 
SNIPKIAA1684SNAP25-interacting protein-HPRD,BioGRID10625663 
STX11FHL4 | HLH4 | HPLH4syntaxin 11Two-hybridBioGRID16169070 |16189514 
STX12MGC51957 | STX13 | STX14syntaxin 12-HPRD,BioGRID10886332 
STX1AHPC-1 | STX1 | p35-1syntaxin 1A (brain)-HPRD7622514 |7768895 
|9556632 |10373452 
|11509230|10954418 
-HPRD7622514 |9556632|10954418 
Affinity Capture-Western
Co-crystal Structure
Reconstituted Complex
Two-hybrid		BioGRID7553862 |7768895 
|7961655 |8663154 
|9852078 |10195194 
|10449403 |10954418 
|11524423 |11832227 
|16169070 
STX2EPIM | EPM | MGC51014 | STX2A | STX2B | STX2Csyntaxin 2-HPRD,BioGRID7768895 
STX3STX3Asyntaxin 3-HPRD,BioGRID7768895 
STX4STX4A | p35-2syntaxin 4-HPRD8760387 
Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID7768895 |8663154 
|9852078 |10194441 
STX5SED5 | STX5Asyntaxin 5Reconstituted ComplexBioGRID9325254 
STXBP1EIEE4 | MUNC18-1 | UNC18 | hUNC18 | rbSec1syntaxin binding protein 1-HPRD9395480 
STXBP6FLJ39638 | HSPC156 | amisynsyntaxin binding protein 6 (amisyn)-HPRD12145319 
SYT1DKFZp781D2042 | P65 | SVP65 | SYTsynaptotagmin I-HPRD,BioGRID10692432 
SYT3DKFZp761O132 | SytIIIsynaptotagmin III-HPRD,BioGRID10692432 
SYT9FLJ45896synaptotagmin IX-HPRD12062043 
TRIM9KIAA0282 | RNF91 | SPRINGtripartite motif-containing 9-HPRD,BioGRID11524423 
UNC13BMGC133279 | MGC133280 | MUNC13 | UNC13 | Unc13h2 | hmunc13unc-13 homolog B (C. elegans)Co-fractionationBioGRID8999968 
VAMP2FLJ11460 | SYB2 | VAMP-2vesicle-associated membrane protein 2 (synaptobrevin 2)-HPRD7961655 
Affinity Capture-Western
Co-crystal Structure
Far Western
Reconstituted Complex
Two-hybrid		BioGRID9030619 |11524423 
|11832227 
VAMP7SYBL1 | TI-VAMP | VAMP-7vesicle-associated membrane protein 7-HPRD,BioGRID12853575 
VAMP8EDBvesicle-associated membrane protein 8 (endobrevin)-HPRD10336434 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_SNARE_INTERACTIONS_IN_VESICULAR_TRANSPORT 3825All SZGR genes in this pathway
REACTOME_BOTULINUM_NEUROTOXICITY 1914All SZGR genes in this pathway
REACTOME_PROTEOLYTIC_CLEAVAGE_OF_SNARE_COMPLEX_PROTEINS 1712All SZGR genes in this pathway
REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE 1513All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_NEUROTRANSMITTER_RELEASE_CYCLE 3430All SZGR genes in this pathway
REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 12084All SZGR genes in this pathway
REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE 1111All SZGR genes in this pathway
REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE 109All SZGR genes in this pathway
REACTOME_DIABETES_PATHWAYS 13391All SZGR genes in this pathway
REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE 1010All SZGR genes in this pathway
REACTOME_INSULIN_SYNTHESIS_AND_PROCESSING 2115All SZGR genes in this pathway
REACTOME_REGULATION_OF_INSULIN_SECRETION 9365All SZGR genes in this pathway
REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION 1716All SZGR genes in this pathway
JAEGER_METASTASIS_UP 4423All SZGR genes in this pathway
UDAYAKUMAR_MED1_TARGETS_DN 240171All SZGR genes in this pathway
LEE_NEURAL_CREST_STEM_CELL_UP 14699All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP 584356All SZGR genes in this pathway
WATTEL_AUTONOMOUS_THYROID_ADENOMA_UP 7347All SZGR genes in this pathway
LIAO_METASTASIS 539324All SZGR genes in this pathway
AMIT_EGF_RESPONSE_20_HELA 118All SZGR genes in this pathway
ROZANOV_MMP14_TARGETS_UP 266171All SZGR genes in this pathway
NELSON_RESPONSE_TO_ANDROGEN_UP 8661All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
SATO_SILENCED_BY_METHYLATION_IN_PANCREATIC_CANCER_1 419273All SZGR genes in this pathway
LEIN_NEURON_MARKERS 6945All SZGR genes in this pathway
WANG_LSD1_TARGETS_DN 3930All SZGR genes in this pathway
KONDO_PROSTATE_CANCER_HCP_WITH_H3K27ME3 9772All SZGR genes in this pathway
HELLER_HDAC_TARGETS_SILENCED_BY_METHYLATION_UP 461298All SZGR genes in this pathway
VICENT_METASTASIS_UP 1411All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
RUIZ_TNC_TARGETS_UP 153107All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_UP 344215All SZGR genes in this pathway
DELACROIX_RAR_BOUND_ES 462273All SZGR genes in this pathway
RAO_BOUND_BY_SALL4_ISOFORM_A 182108All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/2063603671A,m8hsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-1283543601Ahsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
hsa-miR-128aUCACAGUGAACCGGUCUCUUUU
hsa-miR-128bUCACAGUGAACCGGUCUCUUUC
miR-130/3014985051A,m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-1386926981Ahsa-miR-138brainAGCUGGUGUUGUGAAUC
miR-15310221028m8hsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-200bc/429661667m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-2711031109m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-342110511111Ahsa-miR-342brainUCUCACACAGAAAUCGCACCCGUC
miR-361105510611Ahsa-miR-361brainUUAUCAGAAUCUCCAGGGGUAC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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