Gene Page: STK11

Summary ?
GeneID6794
SymbolSTK11
SynonymsLKB1|PJS|hLKB1
Descriptionserine/threonine kinase 11
ReferenceMIM:602216|HGNC:HGNC:11389|Ensembl:ENSG00000118046|HPRD:03740|
Gene typeprotein-coding
Map location19p13.3
Pascal p-value0.05
Sherlock p-value0.425
Fetal beta-0.566
DMG1 (# studies)
eGeneMyers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0208 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg17267676191194783STK118.6E-9-0.013.99E-6DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs16829545chr2151977407STK1167940trans
rs7584986chr2184111432STK1167940.02trans
rs7787830chr798797019STK1167940.01trans
rs11216033chr1198457483STK1167940.09trans
rs16955618chr1529937543STK1167949.798E-5trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
COX5B0.850.71
TMEM2190.850.74
COX4I10.830.68
NENF0.830.69
MSRB20.820.72
HINT20.810.68
SEPW10.810.68
C19orf700.810.67
C12orf620.810.70
NDUFB90.810.64
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
BAT2D1-0.61-0.58
MACF1-0.55-0.53
BDP1-0.55-0.54
ZC3H13-0.54-0.53
BOD1L-0.54-0.53
UPF2-0.53-0.50
CHD2-0.53-0.53
RAPH1-0.52-0.51
MDN1-0.52-0.50
GIGYF2-0.52-0.49

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingIDA12805220 
GO:0005515protein bindingIPI17216128 
GO:0005524ATP bindingIDA12805220 
GO:0004674protein serine/threonine kinase activityIDA12805220 
GO:0016740transferase activityIEA-
GO:0030145manganese ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006468protein amino acid phosphorylationIDA12805220 
GO:0007049cell cycleIEA-
GO:0007050cell cycle arrestIDA12805220 |17216128 
GO:0008285negative regulation of cell proliferationIMP17216128 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIDA12805220 
GO:0005737cytoplasmIDA12805220 |17216128 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CAB39CGI-66 | FLJ22682 | MO25calcium binding protein 39Affinity Capture-WesternBioGRID15561763 
CAB39CGI-66 | FLJ22682 | MO25calcium binding protein 39-HPRD14676191 
CDC37P50CDC37cell division cycle 37 homolog (S. cerevisiae)-HPRD,BioGRID12489981 
HSP90AA1FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2heat shock protein 90kDa alpha (cytosolic), class A member 1Affinity Capture-Western
Reconstituted Complex		BioGRID12489981 
MARK2EMK1 | MGC99619 | PAR-1 | Par1bMAP/microtubule affinity-regulating kinase 2-HPRD14976552 
MARK4FLJ90097 | KIAA1860 | MARKL1 | Nbla00650MAP/microtubule affinity-regulating kinase 4LKB1 phosphorylates MARK4.BIND14676191 
PRKAA2AMPK | AMPK2 | PRKAAprotein kinase, AMP-activated, alpha 2 catalytic subunitLKB1 interacts with AMPK-alpha.BIND14985505 
SMARCA4BAF190 | BRG1 | FLJ39786 | SNF2 | SNF2-BETA | SNF2L4 | SNF2LB | SWI2 | hSNF2bSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4-HPRD,BioGRID11445556 
STK11LKB1 | PJSserine/threonine kinase 11LKB1 autophosphorylates itself.BIND14676191 
STK11IPKIAA1898 | LIP1 | LKB1IP | STK11IP1serine/threonine kinase 11 interacting protein-HPRD,BioGRID11741830 
STRADAFLJ90524 | LYK5 | NY-BR-96 | PMSE | STRAD | StlkSTE20-related kinase adaptor alpha-HPRD,BioGRID12805220 
STRADBALS2CR2 | CALS-21 | ILPIP | ILPIPA | MGC102916 | PAPK | PRO1038STE20-related kinase adaptor betaLKB1 phosphorylates PAPK.BIND14676191 
TNIP2ABIN-2 | ABIN2 | FLIP1 | KLIP | MGC4289TNFAIP3 interacting protein 2-HPRD12595760 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53-HPRD,BioGRID11430832 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG MTOR SIGNALING PATHWAY 5240All SZGR 2.0 genes in this pathway
KEGG ADIPOCYTOKINE SIGNALING PATHWAY 6757All SZGR 2.0 genes in this pathway
PID LKB1 PATHWAY 4737All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE 1916All SZGR 2.0 genes in this pathway
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE 8764All SZGR 2.0 genes in this pathway
REACTOME INTEGRATION OF ENERGY METABOLISM 12084All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 1513All SZGR 2.0 genes in this pathway
REACTOME ENERGY DEPENDENT REGULATION OF MTOR BY LKB1 AMPK 1815All SZGR 2.0 genes in this pathway
REACTOME PKB MEDIATED EVENTS 2923All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY INSULIN RECEPTOR 10872All SZGR 2.0 genes in this pathway
REACTOME PI3K CASCADE 7151All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
WANG LMO4 TARGETS UP 372227All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN 335193All SZGR 2.0 genes in this pathway
BIDUS METASTASIS DN 16193All SZGR 2.0 genes in this pathway
CORRADETTI MTOR PATHWAY REGULATORS DN 65All SZGR 2.0 genes in this pathway
GALLUZZI PERMEABILIZE MITOCHONDRIA 4331All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE AUGMENTED BY MYC 10874All SZGR 2.0 genes in this pathway
DING LUNG CANCER MUTATED SIGNIFICANTLY 2622All SZGR 2.0 genes in this pathway
DING LUNG CANCER MUTATED FREQUENTLY 1210All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL AND BRAIN QTL TRANS 185114All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN 287208All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR DN 911527All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR DN 1011592All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN 354216All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540340All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP 374247All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323240All SZGR 2.0 genes in this pathway
DING LUNG CANCER MUTATED RECURRENTLY 65All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG BOUND 8D 658397All SZGR 2.0 genes in this pathway
DELACROIX RARG BOUND MEF 367231All SZGR 2.0 genes in this pathway
DELACROIX RAR TARGETS UP 4833All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES 462273All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 COMPLETE 227151All SZGR 2.0 genes in this pathway