Gene Page: TSC2

Summary
GeneID  7249
Symbol  TSC2
Synonyms  FLJ43106|LAM|TSC4
Description  tuberous sclerosis 2
See related  HGNC:12363|MIM:191092|Ensembl:ENSG00000103197|HPRD:01850|
Locus tag  -
Gene type  protein-coding
Map location  16p13.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0217 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
TTC7B0.520.53
AKTIP0.520.53
AUH0.520.52
STAR0.520.49
EPDR10.510.51
SLC25A400.510.47
DNAJA40.510.50
IDH3A0.510.52
HSPA4L0.500.51
C1orf1960.500.49
Top 10 negatively co-expressed genes
AC010300.1-0.27-0.24
RP9P-0.26-0.30
BCL7C-0.25-0.31
RBMX2-0.25-0.22
AC005921.3-0.25-0.28
FAM159B-0.24-0.35
CLEC3B-0.23-0.29
SH2D2A-0.23-0.23
ANP32C-0.23-0.21
AF347015.18-0.23-0.08
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005096GTPase activator activityIDA9045618 
GO:0005515protein bindingIPI9580671 |10585443 |12364343 
GO:0042803protein homodimerization activityIPI10585443 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001843neural tube closureISS-
GO:0030100regulation of endocytosisISS-
GO:0006469negative regulation of protein kinase activityISS-
GO:0006606protein import into nucleusISS-
GO:0008285negative regulation of cell proliferationISS-
GO:0014067negative regulation of phosphoinositide 3-kinase cascadeISS-
GO:0007507heart developmentISS-
GO:0008104protein localizationISS-
GO:0048009insulin-like growth factor receptor signaling pathwayISS-
GO:0051056regulation of small GTPase mediated signal transductionIEA-
GO:0050918positive chemotaxisISS-
GO:0045786negative regulation of cell cycleIEA-
GO:0043547positive regulation of GTPase activityIEA-
GO:0046626regulation of insulin receptor signaling pathwayISS-
GO:0051898negative regulation of protein kinase B signaling cascadeISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005794Golgi apparatusIDA8806680 
GO:0005794Golgi apparatusIDA10585443 
GO:0005829cytosolEXP15314020 |15589136 
GO:0005829cytosolIDA10585443 
GO:0005622intracellularIEA-
GO:0005624membrane fractionIDA16636147 
GO:0005634nucleusIDA17114346 
GO:0005634nucleusIDA16636147 
GO:0005737cytoplasmIDA9580671 |16636147 
GO:0005737cytoplasmIDA17114346 
GO:0016020membraneIEA-
GO:0048471perinuclear region of cytoplasmIDA8806680 
GO:0033596TSC1-TSC2 complexIDA9580671 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AKT1AKT | MGC99656 | PKB | PKB-ALPHA | PRKBA | RAC | RAC-ALPHAv-akt murine thymoma viral oncogene homolog 1-HPRD,BioGRID12167664 
Akt interacts with and phosphorylates tuberin. This interaction was modelled on a demonstrated interaction between Akt from an unspecified species and human Tuberin.BIND12150915 
AXIN1AXIN | MGC52315axin 1Affinity Capture-WesternBioGRID12511557 
CAV1CAV | MSTP085 | VIP21caveolin 1, caveolae protein, 22kDaCo-purificationBioGRID12147258 
CCND1BCL1 | D11S287E | PRAD1 | U21B31cyclin D1Affinity Capture-WesternBioGRID16357142 
CCND2KIAK0002 | MGC102758cyclin D2Affinity Capture-WesternBioGRID16357142 
CCND3-cyclin D3Affinity Capture-WesternBioGRID16357142 
CDKN1BCDKN4 | KIP1 | MEN1B | MEN4 | P27KIP1cyclin-dependent kinase inhibitor 1B (p27, Kip1)Affinity Capture-WesternBioGRID15355997 
FOXO1FKH1 | FKHR | FOXO1Aforkhead box O1Affinity Capture-Western
Co-localization
Reconstituted Complex		BioGRID17077083 
GSK3B-glycogen synthase kinase 3 betaAffinity Capture-Western
Biochemical Activity		BioGRID12511557 |16959574 
MAPK1ERK | ERK2 | ERT1 | MAPK2 | P42MAPK | PRKM1 | PRKM2 | p38 | p40 | p41 | p41mapkmitogen-activated protein kinase 1Affinity Capture-Western
Reconstituted Complex		BioGRID15851026 
Erk2 interacts with TSC2. This interaction was modelled on a demonstrated interaction between Erk2 from an unspecified species and human TSC2.BIND15851026 
NEK1DKFZp686D06121 | DKFZp686K12169 | KIAA1901 | MGC138800 | NY-REN-55NIMA (never in mitosis gene a)-related kinase 1NEK1 interacts with Tuberin.BIND14690447 
PAMPAL | PHMpeptidylglycine alpha-amidating monooxygenaseAffinity Capture-Western
Co-localization
Two-hybrid		BioGRID14559897 
PLK1PLK | STPK13polo-like kinase 1 (Drosophila)Affinity Capture-WesternBioGRID16339216 
PRKAA1AMPK | AMPKa1 | MGC33776 | MGC57364protein kinase, AMP-activated, alpha 1 catalytic subunitAffinity Capture-Western
Reconstituted Complex		BioGRID14651849 |15261145 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2Affinity Capture-Western
Reconstituted Complex		BioGRID17043358 
RAB5ARAB5RAB5A, member RAS oncogene family-HPRD9045618 
Co-purificationBioGRID12147258 
RABEP1RAB5EP | RABPT5rabaptin, RAB GTPase binding effector protein 1-HPRD9045618 
RALAMGC48949 | RALv-ral simian leukemia viral oncogene homolog A (ras related)Affinity Capture-WesternBioGRID12842888 
RAP1AKREV-1 | KREV1 | RAP1 | SMGP21RAP1A, member of RAS oncogene familyAffinity Capture-Western
Co-purification		BioGRID12147258 |12842888 
RHEBMGC111559 | RHEB2Ras homolog enriched in brain-HPRD,BioGRID12842888 
TSC2 interacts with Rheb.BIND15854902 
RPS6KA1HU-1 | MAPKAPK1A | RSK | RSK1ribosomal protein S6 kinase, 90kDa, polypeptide 1Affinity Capture-Western
Reconstituted Complex		BioGRID15342917 |15757502 
SFNYWHASstratifin-HPRD12438239 
SKP2FBL1 | FBXL1 | FLB1 | MGC1366S-phase kinase-associated protein 2 (p45)Phenotypic SuppressionBioGRID15355997 
TSC1KIAA0243 | LAM | MGC86987 | TSCtuberous sclerosis 1Affinity Capture-MS
Affinity Capture-Western
Co-localization
Co-purification
Two-hybrid		BioGRID9580671 |10585443 
|10807585 |10915759 
|11175345 |11290735 
|11741832 |11741833 
|12167664 |12176984 
|12468542 |12511557 
|14551205 |14651849 
|15340059 |15851026 
|15963462 |16339216 
|16424383 |16636147 
|17077083 
-HPRD10915759 |11741833 
-HPRD9580671 |10915759 
|11741833|10915759 |11741833 
Hamartin interacts with tuberinBIND9580671 
UBE3AANCR | AS | E6-AP | EPVE6AP | FLJ26981 | HPVE6Aubiquitin protein ligase E3AReconstituted ComplexBioGRID15175323 
YWHAA-tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptideAffinity Capture-Western
Two-hybrid		BioGRID12176984 |12364343 
|12468542 |12582162 
|16636147 
YWHABGW128 | HS1 | KCIP-1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide-HPRD12438239 |12468542 
The tumor suppressor protein tuberin interacts with 14-3-3-beta isoform. This interaction is modeled on demonstrated interaction between human tuberin and mouse 14-3-3-beta isoform.BIND12176984 
YWHAE14-3-3E | FLJ45465 | KCIP-1 | MDCR | MDStyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide-HPRD12438239 
Tumor suppressor protein tuberin interacts with 14-3-3-epsilon isoform. This interaction is modeled on demonstrated interaction between human tuberin and mouse 14-3-3-epsilon isoform.BIND12176984 
YWHAG14-3-3GAMMAtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide-HPRD12438239 
The tumor suppressor protein tuberin interacts with 14-3-3-gamma isoform. This interaction is modeled on demonstrated interaction between human tuberin and mouse 14-3-3-gamma.BIND12176984 
YWHAHYWHA1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide-HPRD12438239 
The tumor suppressor protein tuberin interacts with 14-3-3-eta isoform. This interaction is modeled on demonstrated interaction between human tuberin and mouse 14-3-3-eta isoform.BIND12176984 
YWHAQ14-3-3 | 1C5 | HS1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptideAffinity Capture-MSBioGRID17353931 
Tumor suppressor protein tuberin interacts with 14-3-3-tau isoform. This interaction is modeled on demonstrated interaction between human tuberin and mouse 14-3-3-tau isoform.BIND12176984 
-HPRD12438239 
YWHAZKCIP-1 | MGC111427 | MGC126532 | MGC138156tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide-HPRD12176984 |12438239 
|12468542 
-HPRD,BioGRID12176984 
Tumor suppressor protein tuberin interacts with 14-3-3-zeta isoform.BIND11533041 |12176984 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_P53_SIGNALING_PATHWAY 6945All SZGR genes in this pathway
KEGG_MTOR_SIGNALING_PATHWAY 5240All SZGR genes in this pathway
KEGG_INSULIN_SIGNALING_PATHWAY 137103All SZGR genes in this pathway
BIOCARTA_VDR_PATHWAY 127All SZGR genes in this pathway
BIOCARTA_MTOR_PATHWAY 2315All SZGR genes in this pathway
SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES 6754All SZGR genes in this pathway
PID_LKB1_PATHWAY 4737All SZGR genes in this pathway
PID_MTOR_4PATHWAY 6955All SZGR genes in this pathway
PID_P53_DOWNSTREAM_PATHWAY 13794All SZGR genes in this pathway
PID_P38_MK2_PATHWAY 2119All SZGR genes in this pathway
PID_MYC_REPRESS_PATHWAY 6352All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_SIGNALING_BY_SCF_KIT 7859All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB4 9067All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB2 10178All SZGR genes in this pathway
REACTOME_SIGNALING_BY_EGFR_IN_CANCER 10980All SZGR genes in this pathway
REACTOME_PI3K_EVENTS_IN_ERBB4_SIGNALING 3828All SZGR genes in this pathway
REACTOME_PI3K_EVENTS_IN_ERBB2_SIGNALING 4434All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR 9766All SZGR genes in this pathway
REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 12690All SZGR genes in this pathway
REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 8764All SZGR genes in this pathway
REACTOME_NGF_SIGNALLING_VIA_TRKA_FROM_THE_PLASMA_MEMBRANE 137105All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR_IN_DISEASE 12788All SZGR genes in this pathway
REACTOME_PI3K_AKT_ACTIVATION 3829All SZGR genes in this pathway
REACTOME_AKT_PHOSPHORYLATES_TARGETS_IN_THE_CYTOSOL 1210All SZGR genes in this pathway
REACTOME_GAB1_SIGNALOSOME 3829All SZGR genes in this pathway
REACTOME_SIGNALING_BY_PDGF 12293All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 9576All SZGR genes in this pathway
REACTOME_PI_3K_CASCADE 5639All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNALING_OF_ACTIVATED_FGFR 10074All SZGR genes in this pathway
REACTOME_ENERGY_DEPENDENT_REGULATION_OF_MTOR_BY_LKB1_AMPK 1815All SZGR genes in this pathway
REACTOME_REGULATION_OF_RHEB_GTPASE_ACTIVITY_BY_AMPK 109All SZGR genes in this pathway
REACTOME_PKB_MEDIATED_EVENTS 2923All SZGR genes in this pathway
REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 10872All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_ADAPTIVE_IMMUNE_SYSTEM 539350All SZGR genes in this pathway
REACTOME_PIP3_ACTIVATES_AKT_SIGNALING 2920All SZGR genes in this pathway
REACTOME_SIGNALING_BY_FGFR 11280All SZGR genes in this pathway
REACTOME_PI3K_CASCADE 7151All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_DN 508354All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
APPIERTO_RESPONSE_TO_FENRETINIDE_UP 3826All SZGR genes in this pathway
BENPORATH_MYC_TARGETS_WITH_EBOX 230156All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_16P13_AMPLICON 12049All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_HNE_AND_H2O2 3929All SZGR genes in this pathway
DAIRKEE_CANCER_PRONE_RESPONSE_E2 2821All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
MOOTHA_PGC 420269All SZGR genes in this pathway
YAGI_AML_WITH_T_8_21_TRANSLOCATION 368247All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway


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