Gene Page: TSHR

Summary ?
GeneID7253
SymbolTSHR
SynonymsCHNG1|LGR3|hTSHR-I
Descriptionthyroid stimulating hormone receptor
ReferenceMIM:603372|HGNC:HGNC:12373|Ensembl:ENSG00000165409|HPRD:04537|Vega:OTTHUMG00000171429
Gene typeprotein-coding
Map location14q31
Pascal p-value0.069
Fetal beta-0.369
DMG1 (# studies)
eGeneCaudate basal ganglia
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 2
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0146 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg214879501481421770TSHR2.287E-40.4680.036DMG:Wockner_2014
cg161080591481421989TSHR3.301E-4-0.5010.041DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs10994209chr1061877705TSHR72530.1trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
GSPT10.950.95
DIS30.940.94
C17orf710.940.94
FAM172A0.930.95
DCTN40.930.95
VEZT0.930.95
ZMYM40.930.96
MARCH50.930.94
WDR480.930.94
KPNA30.930.94
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FXYD1-0.77-0.87
MT-CO2-0.75-0.85
AF347015.31-0.74-0.83
AF347015.33-0.74-0.83
IFI27-0.73-0.83
AF347015.8-0.72-0.83
AF347015.27-0.71-0.81
HIGD1B-0.71-0.83
MT-CYB-0.71-0.81
AC021016.1-0.71-0.80

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004996thyroid-stimulating hormone receptor activityIEA-
GO:0004996thyroid-stimulating hormone receptor activityTAS8552586 
GO:0004872receptor activityIEA-
GO:0005515protein bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007189G-protein signaling, adenylate cyclase activating pathwayIEA-
GO:0007187G-protein signaling, coupled to cyclic nucleotide second messengerTAS8552586 
GO:0007186G-protein coupled receptor protein signaling pathwayIEA-
GO:0007267cell-cell signalingTAS7920658 
GO:0007165signal transductionIEA-
GO:0008284positive regulation of cell proliferationTAS7920658 
GO:0008344adult locomotory behaviorIEA-
GO:0040012regulation of locomotionIEA-
GO:0040018positive regulation of multicellular organism growthIEA-
GO:0030183B cell differentiationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0016021integral to membraneIEA-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS8552586 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CALCRCRT | CTR | CTR1calcitonin receptorAffinity Capture-WesternBioGRID12383251 
CALRCRT | FLJ26680 | RO | SSA | cC1qRcalreticulin-HPRD12383251 
CALRCRT | FLJ26680 | RO | SSA | cC1qRcalreticulinTSHR interacts with the molecular chaperone protein calreticulin. This interaction was modeled on a demonstrated interaction between human TSHR and rabbit calreticulin.BIND12383251 
CANXCNX | FLJ26570 | IP90 | P90calnexinThyroid-Stimulating Hormone Receptor interacts with the molecular chaperone calnexin. This interaction was modeled on a demonstrated interaction between human TSHR and dog calnexin.BIND12383251 
CANXCNX | FLJ26570 | IP90 | P90calnexin-HPRD,BioGRID12383251 
FLNBABP-278 | AOI | DKFZp686A1668 | DKFZp686O033 | FH1 | FLN1L | LRS1 | SCT | TABP | TAPfilamin B, beta (actin binding protein 278)-HPRD,BioGRID8327473 
FN1CIG | DKFZp686F10164 | DKFZp686H0342 | DKFZp686I1370 | DKFZp686O13149 | ED-B | FINC | FN | FNZ | GFND | GFND2 | LETS | MSFfibronectin 1-HPRD,BioGRID11981027 
GNA12MGC104623 | MGC99644 | NNX3 | RMP | gepguanine nucleotide binding protein (G protein) alpha 12-HPRD8552586 
GNA13G13 | MGC46138guanine nucleotide binding protein (G protein), alpha 13-HPRD8552586 
GNAQG-ALPHA-q | GAQguanine nucleotide binding protein (G protein), q polypeptide-HPRD8188646 
GNASAHO | C20orf45 | GNAS1 | GPSA | GSA | GSP | MGC33735 | PHP1A | PHP1B | POH | dJ309F20.1.1 | dJ806M20.3.3GNAS complex locus-HPRD9525885 
HSPA5BIP | FLJ26106 | GRP78 | MIF2heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)TSHR interacts with BiP. This interaction was modeled on a demonstrated interaction between human TSHR and hamster BiP.BIND12383251 
HSPA5BIP | FLJ26106 | GRP78 | MIF2heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)-HPRD,BioGRID12383251 
JAK1JAK1A | JAK1B | JTK3Janus kinase 1 (a protein tyrosine kinase)-HPRD,BioGRID10809230 
JAK2JTK10Janus kinase 2 (a protein tyrosine kinase)-HPRD,BioGRID10809230 
LHCGRFLJ41504 | LCGR | LGR2 | LH/CG-R | LH/CGR | LHR | LHRHR | LSH-Rluteinizing hormone/choriogonadotropin receptor-HPRD1651314 
SCRIBCRIB1 | SCRB1 | SCRIB1 | Vartulscribbled homolog (Drosophila)TSHR interacts with an unspecified isoform of SCRIB.BIND15775968 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)-HPRD,BioGRID10809230 
TSHBCHNG4 | TSH-BETAthyroid stimulating hormone, beta-HPRD2558651 
TSHRCHNG1 | LGR3 | MGC75129 | hTSHR-Ithyroid stimulating hormone receptorTSHr homodimerizes.BIND15889138 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION 272195All SZGR 2.0 genes in this pathway
KEGG AUTOIMMUNE THYROID DISEASE 5349All SZGR 2.0 genes in this pathway
PID ARF6 TRAFFICKING PATHWAY 4934All SZGR 2.0 genes in this pathway
PID ARF6 PATHWAY 3527All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS 305177All SZGR 2.0 genes in this pathway
REACTOME HORMONE LIGAND BINDING RECEPTORS 108All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME G ALPHA S SIGNALLING EVENTS 12182All SZGR 2.0 genes in this pathway
REACTOME GPCR LIGAND BINDING 408246All SZGR 2.0 genes in this pathway
GRABARCZYK BCL11B TARGETS DN 5735All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 DN 242165All SZGR 2.0 genes in this pathway
HATADA METHYLATED IN LUNG CANCER UP 390236All SZGR 2.0 genes in this pathway
NADLER OBESITY DN 4834All SZGR 2.0 genes in this pathway
NATSUME RESPONSE TO INTERFERON BETA DN 5233All SZGR 2.0 genes in this pathway
LOPES METHYLATED IN COLON CANCER DN 2826All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION DN 10567All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN 292189All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN 281179All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673430All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS UP 602364All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS UP 601369All SZGR 2.0 genes in this pathway
AMBROSINI FLAVOPIRIDOL TREATMENT TP53 10963All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323240All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
LEE EARLY T LYMPHOCYTE UP 10759All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422277All SZGR 2.0 genes in this pathway
FONTAINE THYROID TUMOR UNCERTAIN MALIGNANCY UP 3623All SZGR 2.0 genes in this pathway