Gene Page: UPK2
Summary ?
| GeneID | 7379 |
| Symbol | UPK2 |
| Synonyms | UP2|UPII |
| Description | uroplakin 2 |
| Reference | MIM:611558|HGNC:HGNC:12579|Ensembl:ENSG00000110375|HPRD:10295|Vega:OTTHUMG00000166346 |
| Gene type | protein-coding |
| Map location | 11q23 |
| Pascal p-value | 0.009 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.006 |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs10994209 | chr10 | 61877705 | UPK2 | 7379 | 0.11 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| KDM3A | 0.68 | 0.57 |
| DDIT4 | 0.65 | 0.48 |
| HK2 | 0.65 | 0.60 |
| EPHA2 | 0.64 | 0.60 |
| JUN | 0.64 | 0.53 |
| HES1 | 0.64 | 0.49 |
| ZNF442 | 0.63 | 0.39 |
| ARRDC3 | 0.63 | 0.42 |
| GYS1 | 0.61 | 0.66 |
| PRKD1 | 0.60 | 0.60 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| LY96 | -0.39 | -0.44 |
| NDUFB9 | -0.38 | -0.43 |
| ZFAND2A | -0.37 | -0.36 |
| GSTO1 | -0.37 | -0.39 |
| SEPW1 | -0.36 | -0.45 |
| NDUFA4 | -0.35 | -0.39 |
| NENF | -0.35 | -0.40 |
| RERGL | -0.35 | -0.42 |
| NDUFV2 | -0.34 | -0.38 |
| GMFG | -0.34 | -0.43 |
Section III. Gene Ontology annotation
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0016044 | membrane organization | IEA | - | |
| GO:0007275 | multicellular organismal development | TAS | 9515818 | |
| GO:0030855 | epithelial cell differentiation | IDA | 10514386 | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005886 | plasma membrane | IEA | - | |
| GO:0005887 | integral to plasma membrane | TAS | 8175808 | |
| GO:0030176 | integral to endoplasmic reticulum membrane | IEA | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| ZHOU INFLAMMATORY RESPONSE LIVE UP | 485 | 293 | All SZGR 2.0 genes in this pathway |
| WANG CLIM2 TARGETS UP | 269 | 146 | All SZGR 2.0 genes in this pathway |
| ZHOU INFLAMMATORY RESPONSE LPS UP | 431 | 237 | All SZGR 2.0 genes in this pathway |
| SCHAEFFER PROSTATE DEVELOPMENT 6HR DN | 514 | 330 | All SZGR 2.0 genes in this pathway |
| SCHAEFFER PROSTATE DEVELOPMENT 48HR UP | 487 | 286 | All SZGR 2.0 genes in this pathway |
| SHEN SMARCA2 TARGETS DN | 357 | 212 | All SZGR 2.0 genes in this pathway |
| LENAOUR DENDRITIC CELL MATURATION DN | 128 | 90 | All SZGR 2.0 genes in this pathway |
| SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1 | 419 | 273 | All SZGR 2.0 genes in this pathway |
| MUELLER COMMON TARGETS OF AML FUSIONS DN | 31 | 21 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF ICP WITH H3K27ME3 | 206 | 108 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN ES ICP WITH H3K4ME3 | 718 | 401 | All SZGR 2.0 genes in this pathway |