SZGR2

Summary ?

GeneID	7532
Symbol	YWHAG
Synonyms	14-3-3GAMMA\|PPP1R170
Description	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
Reference	MIM:605356\|HGNC:HGNC:12852\|Ensembl:ENSG00000170027\|HPRD:05639\|Vega:OTTHUMG00000022862
Gene type	protein-coding
Map location	7q11.23
Pascal p-value	0.17
Sherlock p-value	0.555
Fetal beta	-0.188
DMG	1 (# studies)
eGene	Myers' cis & trans
Support	INTRACELLULAR SIGNAL TRANSDUCTION G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-CONSENSUS G2Cdb.human_BAYES-COLLINS-HUMAN-PSD-FULL G2Cdb.human_BAYES-COLLINS-MOUSE-PSD-CONSENSUS G2Cdb.human_mGluR5 G2Cdb.human_mitochondria G2Cdb.humanNRC G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet Darnell FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Jaffe_2016	Genome-wide DNA methylation analysis	This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05.	1
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	Click to show details
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 2
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 1.9874

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg16256922	7	75988606	YWHAG	2.77E-8	-0.007	8.69E-6	DMG:Jaffe_2016

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	pvalue	qvalue	TSS distance	eQTL type
rs17712061	chr5	18173266	YWHAG	7532		0.14		trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005159	insulin-like growth factor receptor binding	IPI		12482592
GO:0005080	protein kinase C binding	IPI		10433554
GO:0008426	protein kinase C inhibitor activity	NAS		10433554
GO:0019904	protein domain specific binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0048167	regulation of synaptic plasticity	IMP	Synap (GO term level: 8)	11824616
GO:0045664	regulation of neuron differentiation	IMP	neuron, neurogenesis (GO term level: 9)	11824616
GO:0009966	regulation of signal transduction	NAS		10433554 \|10486217
GO:0006469	negative regulation of protein kinase activity	NAS		10433554
GO:0006605	protein targeting	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005737	cytoplasm	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AKAP13	AKAP-Lbc \| BRX \| FLJ11952 \| FLJ43341 \| HA-3 \| Ht31 \| LBC \| PROTO-LB \| PROTO-LBC \| c-lbc	A kinase (PRKA) anchor protein 13	-	HPRD	15324660
ANKS1A	ANKS1 \| KIAA0229 \| MGC42354	ankyrin repeat and sterile alpha motif domain containing 1A	-	HPRD	15324660
ANKS1A	ANKS1 \| KIAA0229 \| MGC42354	ankyrin repeat and sterile alpha motif domain containing 1A	Affinity Capture-MS	BioGRID	17353931
ARAF	A-RAF \| ARAF1 \| PKS2 \| RAFA1	v-raf murine sarcoma 3611 viral oncogene homolog	Affinity Capture-MS	BioGRID	17353931
ARHGEF2	DKFZp547L106 \| DKFZp547P1516 \| GEF \| GEF-H1 \| GEFH1 \| KIAA0651 \| LFP40 \| P40	rho/rac guanine nucleotide exchange factor (GEF) 2	-	HPRD	15324660
ATP5A1	ATP5A \| ATP5AL2 \| ATPM \| MOM2 \| OMR \| ORM \| hATP1	ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle	-	HPRD	15324660
BAIAP2	BAP2 \| IRSP53	BAI1-associated protein 2	Affinity Capture-MS	BioGRID	17353931
BCLAF1	BTF \| KIAA0164 \| bK211L9.1	BCL2-associated transcription factor 1	-	HPRD	15324660
BRAF	B-RAF1 \| BRAF1 \| FLJ95109 \| MGC126806 \| MGC138284 \| RAFB1	v-raf murine sarcoma viral oncogene homolog B1	Affinity Capture-MS	BioGRID	17353931
C22orf9	-	chromosome 22 open reading frame 9	Affinity Capture-MS	BioGRID	17353931
CAPN3	CANP3 \| CANPL3 \| LGMD2 \| LGMD2A \| MGC10767 \| MGC11121 \| MGC14344 \| MGC4403 \| nCL-1 \| p94	calpain 3, (p94)	-	HPRD	15324660
CDC2L1	CDC2L2 \| CDK11 \| CDK11-p110 \| CDK11-p46 \| CDK11-p58 \| CLK-1 \| FLJ59152 \| PK58 \| p58 \| p58CDC2L1 \| p58CLK-1	cell division cycle 2-like 1 (PITSLRE proteins)	CDK11-p110 interacts with 14-3-3-gamma.	BIND	15883043
CGN	DKFZp779N1112 \| FLJ39281 \| KIAA1319	cingulin	-	HPRD	15324660
CGN	DKFZp779N1112 \| FLJ39281 \| KIAA1319	cingulin	Affinity Capture-MS	BioGRID	17353931
CLASP1	DKFZp686D1968 \| DKFZp686H2039 \| FLJ33821 \| FLJ41222 \| KIAA0622 \| MAST1 \| MGC131895	cytoplasmic linker associated protein 1	Affinity Capture-MS	BioGRID	17353931
CLK2	MGC61500 \| hCLK2	CDC-like kinase 2	-	HPRD	15324660
CLK3	FLJ22858 \| PHCLK3 \| PHCLK3/152	CDC-like kinase 3	-	HPRD	15324660
CROP	LUC7A \| OA48-18	cisplatin resistance-associated overexpressed protein	-	HPRD	15324660
CRTC2	RP11-422P24.6 \| TORC2	CREB regulated transcription coactivator 2	Affinity Capture-MS	BioGRID	17353931
CRTC2	RP11-422P24.6 \| TORC2	CREB regulated transcription coactivator 2	-	HPRD	15324660
CSE1L	CAS \| CSE1 \| MGC117283 \| MGC130036 \| MGC130037 \| XPO2	CSE1 chromosome segregation 1-like (yeast)	-	HPRD	15324660
DENND4A	FLJ33949 \| IRLB \| KIAA0476 \| MYCPBP	DENN/MADD domain containing 4A	Affinity Capture-MS	BioGRID	17353931
DFFA	DFF-45 \| DFF1 \| ICAD	DNA fragmentation factor, 45kDa, alpha polypeptide	-	HPRD	15324660
DISC1	C1orf136 \| FLJ13381 \| FLJ21640 \| FLJ25311 \| FLJ41105 \| KIAA0457 \| SCZD9	disrupted in schizophrenia 1	-	HPRD,BioGRID	12506198
DOCK7	KIAA1771 \| ZIR2	dedicator of cytokinesis 7	-	HPRD	15324660
DYRK1A	DYRK \| DYRK1 \| HP86 \| MNB \| MNBH	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A	-	HPRD	15324660
EDC3	FLJ21128 \| FLJ31777 \| LSM16 \| YJDC \| YJEFN2	enhancer of mRNA decapping 3 homolog (S. cerevisiae)	Affinity Capture-MS	BioGRID	17353931
EEF1G	EF1G \| GIG35	eukaryotic translation elongation factor 1 gamma	-	HPRD	15324660
EPB41L3	4.1B \| DAL-1 \| DAL1 \| FLJ37633 \| KIAA0987	erythrocyte membrane protein band 4.1-like 3	-	HPRD,BioGRID	11996670
ERC1	Cast2 \| ELKS \| KIAA1081 \| MGC12974 \| RAB6IP2	ELKS/RAB6-interacting/CAST family member 1	-	HPRD	15324660
ERC1	Cast2 \| ELKS \| KIAA1081 \| MGC12974 \| RAB6IP2	ELKS/RAB6-interacting/CAST family member 1	Affinity Capture-MS	BioGRID	17353931
FAM82A2	FAM82C \| FLJ10579 \| RMD3 \| hRMD-3 \| ptpip51	family with sequence similarity 82, member A2	Affinity Capture-MS	BioGRID	17353931
FARP2	FIR \| FRG \| KIAA0793 \| PLEKHC3	FERM, RhoGEF and pleckstrin domain protein 2	-	HPRD	15324660
FOXO1	FKH1 \| FKHR \| FOXO1A	forkhead box O1	-	HPRD,BioGRID	11237865
FRMD6	C14orf31 \| EX1 \| MGC17921 \| Willin \| c14_5320	FERM domain containing 6	-	HPRD	15324660
FRYL	DKFZp686E205 \| FLJ16177 \| KIAA0826	FRY-like	Affinity Capture-MS	BioGRID	17353931
GBF1	FLJ21263 \| FLJ21500 \| KIAA0248 \| MGC134877 \| MGC134878	golgi-specific brefeldin A resistance factor 1	Affinity Capture-MS	BioGRID	17353931
HDAC4	HA6116 \| HD4 \| HDAC-A \| HDACA \| KIAA0288	histone deacetylase 4	Reconstituted Complex	BioGRID	11504882
IGF1R	CD221 \| IGFIR \| JTK13 \| MGC142170 \| MGC142172 \| MGC18216	insulin-like growth factor 1 receptor	Affinity Capture-MS	BioGRID	17353931
IRS2	-	insulin receptor substrate 2	Affinity Capture-MS	BioGRID	17353931
KIAA0408	FLJ43995 \| RP3-403A15.2	KIAA0408	Two-hybrid	BioGRID	16189514
KIF1B	CMT2 \| CMT2A \| CMT2A1 \| FLJ23699 \| HMSNII \| KIAA0591 \| KIAA1448 \| KLP \| MGC134844	kinesin family member 1B	-	HPRD	15324660
KIF1C	KIAA0706 \| LTXS1	kinesin family member 1C	-	HPRD,BioGRID	10559254
KIF23	CHO1 \| KNSL5 \| MKLP-1 \| MKLP1	kinesin family member 23	Affinity Capture-MS	BioGRID	17353931
KIF23	CHO1 \| KNSL5 \| MKLP-1 \| MKLP1	kinesin family member 23	-	HPRD	15324660
KIF5B	KINH \| KNS \| KNS1 \| UKHC	kinesin family member 5B	Affinity Capture-MS	BioGRID	17353931
KIF5C	FLJ44735 \| KIAA0531 \| KINN \| MGC111478 \| NKHC \| NKHC-2 \| NKHC2	kinesin family member 5C	Affinity Capture-MS	BioGRID	17353931
KLC1	KLC \| KNS2 \| KNS2A \| MGC15245	kinesin light chain 1	Affinity Capture-MS	BioGRID	17353931
KLC2	FLJ12387	kinesin light chain 2	Affinity Capture-MS	BioGRID	17353931
KLC3	KLC2 \| KLC2L \| KLCt \| KNS2B	kinesin light chain 3	Affinity Capture-MS	BioGRID	17353931
KLC3	KLC2 \| KLC2L \| KLCt \| KNS2B	kinesin light chain 3	-	HPRD	15324660
KLC4	KNSL8 \| MGC111777 \| bA387M24.3	kinesin light chain 4	Affinity Capture-MS	BioGRID	17353931
KRT18	CYK18 \| K18	keratin 18	-	HPRD	9524113
KRT31	HA1 \| Ha-1 \| KRTHA1 \| MGC138630 \| hHa1	keratin 31	Affinity Capture-MS	BioGRID	17353931
KRT33B	HA3II \| Ha-3II \| KRTHA3A \| KRTHA3B \| hHa3-II	keratin 33B	Affinity Capture-MS	BioGRID	17353931
KRT85	HB5 \| Hb-5 \| KRTHB5 \| hHb5	keratin 85	Affinity Capture-MS	BioGRID	17353931
LARP1	KIAA0731 \| LARP \| MGC19556	La ribonucleoprotein domain family, member 1	Affinity Capture-MS	BioGRID	17353931
LARP1	KIAA0731 \| LARP \| MGC19556	La ribonucleoprotein domain family, member 1	-	HPRD	15324660
LBR	DHCR14B \| FLJ43126 \| LMN2R \| MGC9041 \| PHA	lamin B receptor	Affinity Capture-MS	BioGRID	17353931
LSR	LISCH7 \| MGC10659 \| MGC48312 \| MGC48503	lipolysis stimulated lipoprotein receptor	-	HPRD	15324660
LUC7L2	CGI-59 \| CGI-74 \| FLJ10657 \| LUC7B2	LUC7-like 2 (S. cerevisiae)	Affinity Capture-MS	BioGRID	17353931
LUC7L2	CGI-59 \| CGI-74 \| FLJ10657 \| LUC7B2	LUC7-like 2 (S. cerevisiae)	-	HPRD	15324660
MAP3K2	MEKK2 \| MEKK2B	mitogen-activated protein kinase kinase kinase 2	-	HPRD	15324660
MAP3K3	MAPKKK3 \| MEKK3	mitogen-activated protein kinase kinase kinase 3	Affinity Capture-MS	BioGRID	14743216
MARK2	EMK1 \| MGC99619 \| PAR-1 \| Par1b	MAP/microtubule affinity-regulating kinase 2	Affinity Capture-MS	BioGRID	17353931
MARK3	CTAK1 \| KP78 \| PAR1A	MAP/microtubule affinity-regulating kinase 3	Affinity Capture-MS	BioGRID	17353931
MICALL1	DKFZp686M2226 \| FLJ45921 \| KIAA1668 \| MICAL-L1 \| MIRAB13	MICAL-like 1	-	HPRD	15324660
MLLT4	AF-6 \| AF6 \| AFADIN \| FLJ34371 \| RP3-431P23.3	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4	Affinity Capture-MS	BioGRID	17353931
MPRIP	KIAA0864 \| M-RIP \| RHOIP3 \| p116Rip	myosin phosphatase Rho interacting protein	Affinity Capture-MS	BioGRID	17353931
MPRIP	KIAA0864 \| M-RIP \| RHOIP3 \| p116Rip	myosin phosphatase Rho interacting protein	-	HPRD	15324660
MYCBP2	DKFZp686M08244 \| FLJ10106 \| FLJ13826 \| FLJ21597 \| FLJ21646 \| KIAA0916 \| PAM	MYC binding protein 2	-	HPRD	15324660
OSBPL3	DKFZp667P1518 \| KIAA0704 \| MGC21526 \| ORP-3 \| ORP3 \| OSBP3	oxysterol binding protein-like 3	Affinity Capture-MS	BioGRID	17353931
PAK4	-	p21 protein (Cdc42/Rac)-activated kinase 4	Affinity Capture-MS	BioGRID	17353931
PARD3	ASIP \| Baz \| Bazooka \| FLJ21015 \| PAR3 \| PAR3alpha \| PARD3A \| SE2-5L16 \| SE2-5LT1 \| SE2-5T2	par-3 partitioning defective 3 homolog (C. elegans)	Affinity Capture-MS	BioGRID	17353931
PARD3B	ALS2CR19 \| MGC16131 \| PAR3B \| PAR3L \| PAR3LC \| PAR3beta \| Par3Lb	par-3 partitioning defective 3 homolog B (C. elegans)	-	HPRD	15324660
PCTK1	FLJ16665 \| PCTAIRE \| PCTAIRE1 \| PCTGAIRE	PCTAIRE protein kinase 1	-	HPRD,BioGRID	12154078
PI4KB	PI4K-BETA \| PI4KIIIbeta \| PI4Kbeta \| PIK4CB \| pi4K92	phosphatidylinositol 4-kinase, catalytic, beta	Affinity Capture-MS	BioGRID	17353931
PI4KB	PI4K-BETA \| PI4KIIIbeta \| PI4Kbeta \| PIK4CB \| pi4K92	phosphatidylinositol 4-kinase, catalytic, beta	-	HPRD	15324660
PNN	DRS \| SDK3 \| memA \| pinin	pinin, desmosome associated protein	-	HPRD	15324660
PPFIBP1	L2 \| hSGT2 \| hSgt2p	PTPRF interacting protein, binding protein 1 (liprin beta 1)	Affinity Capture-MS	BioGRID	17353931
PPIG	CARS-Cyp \| CYP \| MGC133241 \| SRCyp	peptidylprolyl isomerase G (cyclophilin G)	-	HPRD	15324660
PRKCA	AAG6 \| MGC129900 \| MGC129901 \| PKC-alpha \| PKCA \| PRKACA	protein kinase C, alpha	-	HPRD,BioGRID	10433554
PRKCB	MGC41878 \| PKC-beta \| PKCB \| PRKCB1 \| PRKCB2	protein kinase C, beta	-	HPRD,BioGRID	10433554
PRKCD	MAY1 \| MGC49908 \| PKCD \| nPKC-delta	protein kinase C, delta	-	HPRD,BioGRID	10433554
PRKCG	MGC57564 \| PKC-gamma \| PKCC \| PKCG \| SCA14	protein kinase C, gamma	-	HPRD,BioGRID	10433554
PRKCQ	MGC126514 \| MGC141919 \| PRKCT \| nPKC-theta	protein kinase C, theta	-	HPRD,BioGRID	10433554
PRKCZ	PKC-ZETA \| PKC2	protein kinase C, zeta	Affinity Capture-Western	BioGRID	10620507
PRPF19	NMP200 \| PRP19 \| PSO4 \| SNEV \| UBOX4 \| hPSO4	PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae)	-	HPRD	15324660
PRPF40A	FBP-11 \| FBP11 \| FLAF1 \| FLJ20585 \| FNBP3 \| HIP10 \| HYPA \| NY-REN-6	PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)	-	HPRD	15324660
PRPF4B	KIAA0536 \| PR4H \| PRP4 \| PRP4H \| PRP4K \| dJ1013A10.1	PRP4 pre-mRNA processing factor 4 homolog B (yeast)	Affinity Capture-MS	BioGRID	17353931
RAB11FIP2	KIAA0941 \| Rab11-FIP2 \| nRip11	RAB11 family interacting protein 2 (class I)	-	HPRD	15324660
RABEP1	RAB5EP \| RABPT5	rabaptin, RAB GTPase binding effector protein 1	Affinity Capture-MS	BioGRID	17353931
RABGEF1	FLJ32302 \| RABEX5 \| rabex-5	RAB guanine nucleotide exchange factor (GEF) 1	-	HPRD	15324660
RABGEF1	FLJ32302 \| RABEX5 \| rabex-5	RAB guanine nucleotide exchange factor (GEF) 1	Affinity Capture-MS	BioGRID	17353931
RACGAP1	HsCYK-4 \| ID-GAP \| MgcRacGAP	Rac GTPase activating protein 1	Affinity Capture-MS	BioGRID	17353931
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1	-	HPRD	8702721 \|10433554
RAF1	CRAF \| NS5 \| Raf-1 \| c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1	Affinity Capture-MS Affinity Capture-Western	BioGRID	10433554 \|10620507 \|17353931
RAI14	DKFZp564G013 \| KIAA1334 \| NORPEG \| RAI13	retinoic acid induced 14	Affinity Capture-MS	BioGRID	17353931
RALGPS2	FLJ10244 \| FLJ25604 \| KIAA0351 \| dJ595C2.1	Ral GEF with PH domain and SH3 binding motif 2	-	HPRD	15324660
RASAL2	MGC129919 \| nGAP	RAS protein activator like 2	-	HPRD	15324660
SAMD4A	DKFZp434H0350 \| KIAA1053 \| SAMD4 \| SMG \| SMGA \| Smaug \| Smaug1	sterile alpha motif domain containing 4A	-	HPRD	15324660
SAMD4B	FLJ10211 \| MGC99832 \| SMGB	sterile alpha motif domain containing 4B	-	HPRD	15324660
SAMD4B	FLJ10211 \| MGC99832 \| SMGB	sterile alpha motif domain containing 4B	Affinity Capture-MS	BioGRID	17353931
SF3B3	KIAA0017 \| RSE1 \| SAP130 \| SF3b130 \| STAF130	splicing factor 3b, subunit 3, 130kDa	-	HPRD	15324660
SFN	YWHAS	stratifin	Affinity Capture-MS	BioGRID	15778465
SH3BP5L	FLJ33845 \| KIAA1720	SH3-binding domain protein 5-like	-	HPRD	15324660
SHCBP1	FLJ22009 \| MGC26900 \| PAL	SHC SH2-domain binding protein 1	-	HPRD	15324660
SHCBP1	FLJ22009 \| MGC26900 \| PAL	SHC SH2-domain binding protein 1	Affinity Capture-MS	BioGRID	17353931
SMCR7L	FLJ20232 \| HSU79252 \| dJ1104E15.3	Smith-Magenis syndrome chromosome region, candidate 7-like	-	HPRD	15324660
SNRNP200	ASCC3L1 \| BRR2 \| HELIC2 \| U5-200KD	small nuclear ribonucleoprotein 200kDa (U5)	Affinity Capture-MS	BioGRID	17353931
SON	BASS1 \| C21orf50 \| DBP-5 \| FLJ21099 \| FLJ33914 \| KIAA1019 \| NREBP \| SON3	SON DNA binding protein	-	HPRD	15324660
SON	BASS1 \| C21orf50 \| DBP-5 \| FLJ21099 \| FLJ33914 \| KIAA1019 \| NREBP \| SON3	SON DNA binding protein	Affinity Capture-MS	BioGRID	17353931
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	-	HPRD	8702721
SRPK1	SFRSK1	SFRS protein kinase 1	-	HPRD	15324660
SRRM1	160-KD \| MGC39488 \| POP101 \| SRM160	serine/arginine repetitive matrix 1	-	HPRD	15324660
SRRM2	300-KD \| CWF21 \| DKFZp686O15166 \| FLJ21926 \| FLJ22250 \| KIAA0324 \| MGC40295 \| SRL300 \| SRm300	serine/arginine repetitive matrix 2	Affinity Capture-MS	BioGRID	17353931
TBC1D1	KIAA1108 \| TBC \| TBC1	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	-	HPRD	15324660
TJP2	MGC26306 \| X104 \| ZO-2 \| ZO2	tight junction protein 2 (zona occludens 2)	-	HPRD	15324660
TJP2	MGC26306 \| X104 \| ZO-2 \| ZO2	tight junction protein 2 (zona occludens 2)	Affinity Capture-MS	BioGRID	17353931
TNFAIP3	A20 \| MGC104522 \| MGC138687 \| MGC138688 \| OTUD7C \| TNFA1P2	tumor necrosis factor, alpha-induced protein 3	-	HPRD	8702721
TSC1	KIAA0243 \| LAM \| MGC86987 \| TSC	tuberous sclerosis 1	Hamartin interacts with 14-3-3-gamma. This interaction is modeled on demonstrated interaction between human hamartin and mouse 14-3-3-gamma isoform.	BIND	12176984
TSC2	FLJ43106 \| LAM \| TSC4	tuberous sclerosis 2	-	HPRD	12438239
TSC2	FLJ43106 \| LAM \| TSC4	tuberous sclerosis 2	The tumor suppressor protein tuberin interacts with 14-3-3-gamma isoform. This interaction is modeled on demonstrated interaction between human tuberin and mouse 14-3-3-gamma.	BIND	12176984
UCP2	BMIQ4 \| SLC25A8 \| UCPH	uncoupling protein 2 (mitochondrial, proton carrier)	UCP2 interacts with 14.3.3-gamma.	BIND	10785390
UCP3	SLC25A9	uncoupling protein 3 (mitochondrial, proton carrier)	UCP3 interacts with 14.3.3-gamma.	BIND	10785390
ZFP36	G0S24 \| GOS24 \| NUP475 \| RNF162A \| TIS11 \| TTP	zinc finger protein 36, C3H type, homolog (mouse)	-	HPRD	11886850
ZNF295	DKFZp781N1974 \| ZBTB21	zinc finger protein 295	-	HPRD	15324660

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CELL CYCLE	128	84	All SZGR 2.0 genes in this pathway
KEGG OOCYTE MEIOSIS	114	79	All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY	126	103	All SZGR 2.0 genes in this pathway
BIOCARTA CHREBP2 PATHWAY	42	35	All SZGR 2.0 genes in this pathway
SIG PIP3 SIGNALING IN CARDIAC MYOCTES	67	54	All SZGR 2.0 genes in this pathway
SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	51	41	All SZGR 2.0 genes in this pathway
ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	37	29	All SZGR 2.0 genes in this pathway
PID LKB1 PATHWAY	47	37	All SZGR 2.0 genes in this pathway
PID NFAT 3PATHWAY	54	47	All SZGR 2.0 genes in this pathway
PID MTOR 4PATHWAY	69	55	All SZGR 2.0 genes in this pathway
PID FOXO PATHWAY	49	43	All SZGR 2.0 genes in this pathway
PID ERBB1 DOWNSTREAM PATHWAY	105	78	All SZGR 2.0 genes in this pathway
PID IL3 PATHWAY	27	19	All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY	129	103	All SZGR 2.0 genes in this pathway
PID P38 MK2 PATHWAY	21	19	All SZGR 2.0 genes in this pathway
PID BETA CATENIN NUC PATHWAY	80	60	All SZGR 2.0 genes in this pathway
PID A6B1 A6B4 INTEGRIN PATHWAY	46	35	All SZGR 2.0 genes in this pathway
PID INSULIN GLUCOSE PATHWAY	26	24	All SZGR 2.0 genes in this pathway
PID PI3KCI AKT PATHWAY	35	30	All SZGR 2.0 genes in this pathway
PID PI3K PLC TRK PATHWAY	36	31	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE	421	253	All SZGR 2.0 genes in this pathway
REACTOME CELL CYCLE MITOTIC	325	185	All SZGR 2.0 genes in this pathway
REACTOME RECRUITMENT OF MITOTIC CENTROSOME PROTEINS AND COMPLEXES	66	43	All SZGR 2.0 genes in this pathway
REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	59	38	All SZGR 2.0 genes in this pathway
REACTOME MITOTIC G2 G2 M PHASES	81	50	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST TUMORS 324 DN	149	93	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK DN	196	131	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 5 6WK DN	137	97	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 6 7WK UP	197	135	All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 4	61	34	All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN	514	319	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN	848	527	All SZGR 2.0 genes in this pathway
DEN INTERACT WITH LCA5	26	21	All SZGR 2.0 genes in this pathway
STARK HYPPOCAMPUS 22Q11 DELETION UP	53	40	All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE DN	121	79	All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS	882	572	All SZGR 2.0 genes in this pathway
YAO HOXA10 TARGETS VIA PROGESTERONE DN	19	12	All SZGR 2.0 genes in this pathway
HU GENOTOXIN ACTION DIRECT VS INDIRECT 4HR	37	22	All SZGR 2.0 genes in this pathway
ZHONG SECRETOME OF LUNG CANCER AND ENDOTHELIUM	66	47	All SZGR 2.0 genes in this pathway
LEIN NEURON MARKERS	69	45	All SZGR 2.0 genes in this pathway
SANSOM APC MYC TARGETS	217	138	All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN	270	181	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP	973	570	All SZGR 2.0 genes in this pathway
GRADE METASTASIS DN	45	31	All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP	374	247	All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D UP	139	95	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 36HR UP	221	150	All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP	442	263	All SZGR 2.0 genes in this pathway
PHESSE TARGETS OF APC AND MBD2 DN	13	11	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A	898	516	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 36HR	152	88	All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D	882	506	All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES	462	273	All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA VIA KDM3A	53	34	All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4	227	149	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-132/212	232	238	m8	hsa-miR-212^SZ	UAACAGUCUCCAGUCACGGCC
miR-132/212	232	238	m8	hsa-miR-132^brain	UAACAGUCUACAGCCAUGGUCG
miR-135	623	629	m8	hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
				hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
				hsa-miR-135a	UAUGGCUUUUUAUUCCUAUGUGA
				hsa-miR-135b	UAUGGCUUUUCAUUCCUAUGUG
miR-139	2283	2289	m8	hsa-miR-139^brain	UCUACAGUGCACGUGUCU
miR-141/200a	2490	2497	1A,m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	2490	2497	1A,m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-145	1993	1999	1A	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-181	2722	2728	m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-182	158	165	1A,m8	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-200bc/429	590	596	m8	hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
				hsa-miR-200b	UAAUACUGCCUGGUAAUGAUGAC
				hsa-miR-200c	UAAUACUGCCGGGUAAUGAUGG
				hsa-miR-429	UAAUACUGUCUGGUAAAACCGU
miR-204/211	88	94	m8	hsa-miR-204^brain	UUCCCUUUGUCAUCCUAUGCCU
miR-204/211	88	94	m8	hsa-miR-211	UUCCCUUUGUCAUCCUUCGCCU
miR-217	2442	2448	m8	hsa-miR-217	UACUGCAUCAGGAACUGAUUGGAU
miR-217	2442	2448	m8	hsa-miR-217	UACUGCAUCAGGAACUGAUUGGAU
miR-221/222	2737	2743	m8	hsa-miR-221^brain	AGCUACAUUGUCUGCUGGGUUUC
miR-221/222	2737	2743	m8	hsa-miR-222^brain	AGCUACAUCUGGCUACUGGGUCUC
miR-23	2724	2730	m8	hsa-miR-23a^brain	AUCACAUUGCCAGGGAUUUCC
miR-23	2724	2730	m8	hsa-miR-23b^brain	AUCACAUUGCCAGGGAUUACC
miR-30-5p	585	591	1A	hsa-miR-30a-5p	UGUAAACAUCCUCGACUGGAAG
				hsa-miR-30c^brain	UGUAAACAUCCUACACUCUCAGC
				hsa-miR-30d^SZ	UGUAAACAUCCCCGACUGGAAG
				hsa-miR-30b^SZ	UGUAAACAUCCUACACUCAGCU
				hsa-miR-30e-5p	UGUAAACAUCCUUGACUGGA
miR-323	2724	2730	1A	hsa-miR-323^brain	GCACAUUACACGGUCGACCUCU
miR-324-3p	2607	2613	1A	hsa-miR-324-3p	CCACUGCCCCAGGUGCUGCUGG
miR-433-3p	2718	2725	1A,m8	hsa-miR-433^brain	AUCAUGAUGGGCUCCUCGGUGU
miR-485-5p	212	219	1A,m8	hsa-miR-485-5p	AGAGGCUGGCCGUGAUGAAUUC
miR-96	159	165	1A	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: YWHAG