Gene Page: SCG2

Summary
GeneID  7857
Symbol  SCG2
Synonyms  CHGC|SN|SgII
Description  secretogranin II (chromogranin C)
See related  HGNC:10575|MIM:118930|Ensembl:ENSG00000171951|HPRD:06762|
Locus tag  -
Gene type  protein-coding
Map location  2q35-q36
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00916 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.01016 
ExpressionExpressionP value: 2.005 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
NLN0.870.93
GFPT10.860.92
HISPPD10.860.93
PANK30.860.91
CASK0.850.92
PANX10.850.92
RNF1800.850.91
PRKAR2A0.850.91
HSDL10.850.91
PLCXD20.840.92
Top 10 negatively co-expressed genes
AF347015.31-0.64-0.83
HLA-F-0.64-0.74
FXYD1-0.63-0.83
MT-CO2-0.63-0.84
AF347015.27-0.62-0.80
AF347015.33-0.62-0.81
TSC22D4-0.62-0.75
MT-CYB-0.61-0.81
AF347015.8-0.61-0.83
C5orf53-0.61-0.69
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005125cytokine activityIDA14970115 
GO:0005509calcium ion bindingIEA-
GO:0042056chemoattractant activityIDA9473216 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000165MAPKKK cascadeIDA14970115 
GO:0001525angiogenesisIDA14970115 
GO:0001937negative regulation of endothelial cell proliferationTAS9473216 
GO:0001938positive regulation of endothelial cell proliferationIDA14970115 
GO:0007242intracellular signaling cascadeIDA9473216 
GO:0009306protein secretionTAS2745426 
GO:0006954inflammatory responseTAS14970115 
GO:0006928cell motionIDA9473216 
GO:0043066negative regulation of apoptosisIDA14970115 
GO:0050930induction of positive chemotaxisIDA9473216 
GO:0048245eosinophil chemotaxisIDA9473216 
GO:0043542endothelial cell migrationTAS9473216 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceIDA9473216 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
CORRE_MULTIPLE_MYELOMA_UP 7445All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_BASAL_VS_MESENCHYMAL_DN 5036All SZGR genes in this pathway
SABATES_COLORECTAL_ADENOMA_DN 291176All SZGR genes in this pathway
KAN_RESPONSE_TO_ARSENIC_TRIOXIDE 12380All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
RORIE_TARGETS_OF_EWSR1_FLI1_FUSION_DN 3023All SZGR genes in this pathway
IGLESIAS_E2F_TARGETS_UP 151103All SZGR genes in this pathway
WANG_SMARCE1_TARGETS_DN 371218All SZGR genes in this pathway
KAYO_AGING_MUSCLE_UP 244165All SZGR genes in this pathway
OSADA_ASCL1_TARGETS_UP 4630All SZGR genes in this pathway
LABBE_WNT3A_TARGETS_DN 9753All SZGR genes in this pathway
HUNSBERGER_EXERCISE_REGULATED_GENES 3126All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
RUIZ_TNC_TARGETS_UP 153107All SZGR genes in this pathway
KIM_ALL_DISORDERS_OLIGODENDROCYTE_NUMBER_CORR_UP 756494All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
KIM_ALL_DISORDERS_CALB1_CORR_UP 548370All SZGR genes in this pathway
HOELZEL_NF1_TARGETS_UP 13993All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_UP 430288All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-155406412m8hsa-miR-155UUAAUGCUAAUCGUGAUAGGGG
miR-3744094151Ahsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-4953583641Ahsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-5434724781Ahsa-miR-543AAACAUUCGCGGUGCACUUCU
hsa-miR-543AAACAUUCGCGGUGCACUUCU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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