Gene Page: RABEP2

Summary ?
GeneID79874
SymbolRABEP2
SynonymsFRA
Descriptionrabaptin, RAB GTPase binding effector protein 2
ReferenceMIM:611869|HGNC:HGNC:24817|Ensembl:ENSG00000177548|HPRD:17948|Vega:OTTHUMG00000176593
Gene typeprotein-coding
Map location16p11.2
Pascal p-value0.141
Sherlock p-value0.389
DMG1 (# studies)
eGeneCaudate basal ganglia
Myers' cis & trans
SupportINTRACELLULAR TRAFFICKING

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
GSMA_IIEGenome scan meta-analysis (European-ancestry samples)Psr: 0.01775 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg050296381628936777RABEP25.254E-4-0.2440.048DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs6973230chr7146072498RABEP2798740.1trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
LRRC140.920.92
B4GALNT10.920.91
WDTC10.910.89
ZFYVE270.910.90
VAC140.900.90
RNF1230.900.89
GGA30.900.90
NISCH0.900.90
MBD10.900.90
TBC1D250.900.89
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.21-0.75-0.74
MT-CO2-0.71-0.65
AF347015.31-0.70-0.64
AF347015.8-0.70-0.65
MT-CYB-0.68-0.62
AL139819.3-0.68-0.70
AF347015.27-0.68-0.64
AF347015.33-0.66-0.59
AF347015.2-0.66-0.57
AF347015.15-0.65-0.59

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005096GTPase activator activityIEA-
GO:0008083growth factor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006897endocytosisIEA-
GO:0015031protein transportIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIEA-
GO:0005769early endosomeIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
TURASHVILI BREAST LOBULAR CARCINOMA VS LOBULAR NORMAL DN 7442All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL UP 380215All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL UP 450256All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 6HR DN 167100All SZGR 2.0 genes in this pathway
WAMUNYOKOLI OVARIAN CANCER LMP UP 265158All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS BASAL 330217All SZGR 2.0 genes in this pathway
PASQUALUCCI LYMPHOMA BY GC STAGE DN 165104All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412249All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS REQUIRE MYC 210123All SZGR 2.0 genes in this pathway
SANSOM WNT PATHWAY REQUIRE MYC 5843All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA UP 259185All SZGR 2.0 genes in this pathway
BOHN PRIMARY IMMUNODEFICIENCY SYNDROM DN 4031All SZGR 2.0 genes in this pathway