Gene Page: ZBP1
Summary ?
| GeneID | 81030 |
| Symbol | ZBP1 |
| Synonyms | C20orf183|DAI|DLM-1|DLM1 |
| Description | Z-DNA binding protein 1 |
| Reference | MIM:606750|HGNC:HGNC:16176|Ensembl:ENSG00000124256|HPRD:09484|Vega:OTTHUMG00000032824 |
| Gene type | protein-coding |
| Map location | 20q13.31 |
| Pascal p-value | 0.291 |
| DEG p-value | DEG:Sanders_2014:DS1_p=-0.177:DS1_beta=0.002750:DS2_p=2.16e-01:DS2_beta=-0.056:DS2_FDR=4.65e-01 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DEG:Sanders_2013 | Microarray | Whole-genome gene expression profiles using microarrays on lymphoblastoid cell lines (LCLs) from 413 cases and 446 controls. | |
| Expression | Meta-analysis of gene expression | P value: 1.433 |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs10994209 | chr10 | 61877705 | ZBP1 | 81030 | 0.12 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| HMG20B | 0.62 | 0.59 |
| PECI | 0.62 | 0.58 |
| AK2 | 0.60 | 0.54 |
| AKR7A2 | 0.59 | 0.50 |
| RFXANK | 0.59 | 0.53 |
| PSME1 | 0.59 | 0.48 |
| ATP6V0E1 | 0.58 | 0.57 |
| TMED1 | 0.58 | 0.49 |
| DCI | 0.58 | 0.56 |
| CAPG | 0.57 | 0.57 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| PCLO | -0.36 | -0.39 |
| R3HDM1 | -0.35 | -0.38 |
| FBXW7 | -0.35 | -0.37 |
| CACNA1A | -0.35 | -0.38 |
| DPP10 | -0.34 | -0.36 |
| DOCK3 | -0.34 | -0.35 |
| SCN2A | -0.34 | -0.36 |
| LNX1 | -0.34 | -0.35 |
| FGF12 | -0.34 | -0.36 |
| SGIP1 | -0.34 | -0.38 |
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0003677 | DNA binding | IEA | - | |
| GO:0003692 | left-handed Z-DNA binding | NAS | 11842111 | |
| GO:0003723 | RNA binding | IEA | - | |
| GO:0003726 | double-stranded RNA adenosine deaminase activity | IEA | - | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0008150 | biological_process | ND | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0005575 | cellular_component | ND | - |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG CYTOSOLIC DNA SENSING PATHWAY | 56 | 44 | All SZGR 2.0 genes in this pathway |
| REACTOME TRIF MEDIATED TLR3 SIGNALING | 74 | 54 | All SZGR 2.0 genes in this pathway |
| REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI | 18 | 15 | All SZGR 2.0 genes in this pathway |
| REACTOME INNATE IMMUNE SYSTEM | 279 | 178 | All SZGR 2.0 genes in this pathway |
| REACTOME IMMUNE SYSTEM | 933 | 616 | All SZGR 2.0 genes in this pathway |
| ODONNELL TFRC TARGETS UP | 456 | 228 | All SZGR 2.0 genes in this pathway |
| ODONNELL TARGETS OF MYC AND TFRC UP | 83 | 50 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP | 552 | 347 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP | 211 | 136 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN UP | 1142 | 669 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 20Q12 Q13 AMPLICON | 149 | 76 | All SZGR 2.0 genes in this pathway |
| MCDOWELL ACUTE LUNG INJURY DN | 48 | 33 | All SZGR 2.0 genes in this pathway |
| SMID BREAST CANCER NORMAL LIKE UP | 476 | 285 | All SZGR 2.0 genes in this pathway |
| BOYLAN MULTIPLE MYELOMA C D DN | 252 | 155 | All SZGR 2.0 genes in this pathway |
| SHEDDEN LUNG CANCER GOOD SURVIVAL A12 | 317 | 177 | All SZGR 2.0 genes in this pathway |
| COLINA TARGETS OF 4EBP1 AND 4EBP2 | 356 | 214 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MCV6 LCP WITH H3K4ME3 | 162 | 80 | All SZGR 2.0 genes in this pathway |
| BOYLAN MULTIPLE MYELOMA PCA1 UP | 101 | 66 | All SZGR 2.0 genes in this pathway |
| FEVR CTNNB1 TARGETS UP | 682 | 433 | All SZGR 2.0 genes in this pathway |
| DELACROIX RARG BOUND MEF | 367 | 231 | All SZGR 2.0 genes in this pathway |
| DELACROIX RAR TARGETS UP | 48 | 33 | All SZGR 2.0 genes in this pathway |
| BOSCO INTERFERON INDUCED ANTIVIRAL MODULE | 78 | 48 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY | 1725 | 838 | All SZGR 2.0 genes in this pathway |
| HECKER IFNB1 TARGETS | 95 | 54 | All SZGR 2.0 genes in this pathway |