Gene Page: APOL1

Summary ?
GeneID8542
SymbolAPOL1
SynonymsAPO-L|APOL|APOL-I|FSGS4
Descriptionapolipoprotein L1
ReferenceMIM:603743|HGNC:HGNC:618|Ensembl:ENSG00000100342|HPRD:04774|Vega:OTTHUMG00000030427
Gene typeprotein-coding
Map location22q13.1
Pascal p-value0.255

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FAM117B0.960.97
AL096711.20.960.97
CLASP10.960.97
NCAM10.960.96
BRD30.960.96
ZNF4450.950.97
BCORL10.950.96
GPR1610.950.92
SRGAP20.950.97
KIAA15490.950.97
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C5orf53-0.71-0.82
AIFM3-0.71-0.81
HLA-F-0.70-0.79
ALDOC-0.69-0.74
HEPN1-0.69-0.78
SERPINB6-0.69-0.77
TSC22D4-0.69-0.83
S100B-0.69-0.88
FBXO2-0.68-0.66
CLU-0.68-0.73

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI12621437 
GO:0005319lipid transporter activityIEA-
GO:0005254chloride channel activityIDA16020735 
GO:0008289lipid bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0008202steroid metabolic processIEA-
GO:0008203cholesterol metabolic processIEA-
GO:0019835cytolysisIDA12621437 |17192540 
GO:0006821chloride transportIDA16020735 
GO:0006629lipid metabolic processIEA-
GO:0006869lipid transportIEA-
GO:0031640killing of cells of another organismIDA12621437 |17192540 
GO:0042157lipoprotein metabolic processIEA-
GO:0045087innate immune responseIDA17192540 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceIDA17192540 
GO:0031224intrinsic to membraneIC16020735 
GO:0034364high-density lipoprotein particleIDA9325276 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
HORIUCHI WTAP TARGETS UP 306188All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS DN 781465All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN 584395All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS DN 637377All SZGR 2.0 genes in this pathway
SANA RESPONSE TO IFNG UP 7850All SZGR 2.0 genes in this pathway
SANA TNF SIGNALING UP 8356All SZGR 2.0 genes in this pathway
ZHANG ANTIVIRAL RESPONSE TO RIBAVIRIN UP 3021All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN 434302All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE UP 299167All SZGR 2.0 genes in this pathway
CROONQUIST IL6 DEPRIVATION UP 2010All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA MS DN 4624All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA1 UP 7646All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770480All SZGR 2.0 genes in this pathway
BOSCO INTERFERON INDUCED ANTIVIRAL MODULE 7848All SZGR 2.0 genes in this pathway