Gene Page: MPDZ

Summary
GeneID  8777
Symbol  MPDZ
Synonyms  DKFZp781P216|FLJ25909|FLJ34626|FLJ90240|MUPP1
Description  multiple PDZ domain protein
See related  HGNC:7208|MIM:603785|Ensembl:ENSG00000107186|HPRD:09155|
Locus tag  RP11-382H24.1
Gene type  protein-coding
Map location  9p24-p22
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 4 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.1065 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
C70.820.83
SERPIND10.800.68
LUM0.790.67
ASPN0.780.67
BMP50.750.48
COL3A10.750.29
POSTN0.730.54
ISLR0.710.80
TBX180.700.69
FAP0.700.63
Top 10 negatively co-expressed genes
AL022328.1-0.23-0.27
SNHG12-0.22-0.41
AC132872.1-0.20-0.39
SEPT12-0.20-0.32
HES4-0.19-0.36
C1orf61-0.19-0.18
C16orf79-0.19-0.20
AC135724.1-0.19-0.30
ACP6-0.19-0.17
ENHO-0.18-0.08
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI16192269 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042995cell projectionIEAaxon (GO term level: 4)-
GO:0005923tight junctionIEABrain (GO term level: 10)-
GO:0019717synaptosomeIEASynap, Brain (GO term level: 7)-
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005886plasma membraneIEA-
GO:0016324apical plasma membraneIEA-
GO:0030054cell junctionIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CLDN1CLD1 | ILVASC | SEMP1claudin 1-HPRD11689568 
DRD3D3DR | ETM1 | FET1 | MGC149204 | MGC149205dopamine receptor D3-HPRD,BioGRID14499480 
HTR2C5-HT2C | 5-HTR2C | HTR1C5-hydroxytryptamine (serotonin) receptor 2CAffinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID9537516 |11150294 
KITC-Kit | CD117 | PBT | SCFRv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homologReconstituted Complex
Two-hybrid		BioGRID11018522 
PLEKHA1TAPP1pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1-HPRD,BioGRID11802782 
PLEKHA2FLJ25921 | TAPP2pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2Affinity Capture-Western
Two-hybrid		BioGRID11802782 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_TIGHT_JUNCTION 13486All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
ODONNELL_TFRC_TARGETS_UP 456228All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM4 261153All SZGR genes in this pathway
RICKMAN_METASTASIS_UP 344180All SZGR genes in this pathway
BALDWIN_PRKCI_TARGETS_UP 3526All SZGR genes in this pathway
GOTZMANN_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_UP 6955All SZGR genes in this pathway
BENPORATH_NANOG_TARGETS 988594All SZGR genes in this pathway
LE_EGR2_TARGETS_DN 10884All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
HADDAD_T_LYMPHOCYTE_AND_NK_PROGENITOR_UP 7856All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_LONG_TERM 302191All SZGR genes in this pathway
MCCLUNG_CREB1_TARGETS_UP 10072All SZGR genes in this pathway
SARTIPY_BLUNTED_BY_INSULIN_RESISTANCE_DN 1814All SZGR genes in this pathway
AMUNDSON_POOR_SURVIVAL_AFTER_GAMMA_RADIATION_8G 9562All SZGR genes in this pathway
IWANAGA_CARCINOGENESIS_BY_KRAS_PTEN_DN 353226All SZGR genes in this pathway
LEE_LIVER_CANCER_SURVIVAL_UP 185112All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_DN 435289All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G1_DN 4026All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_PROLIFERATION_DN 17997All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
OHGUCHI_LIVER_HNF4A_TARGETS_DN 14985All SZGR genes in this pathway
GABRIELY_MIR21_TARGETS 289187All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway


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