Gene Page: TNFRSF10A
Summary ?
| GeneID | 8797 |
| Symbol | TNFRSF10A |
| Synonyms | APO2|CD261|DR4|TRAILR-1|TRAILR1 |
| Description | tumor necrosis factor receptor superfamily member 10a |
| Reference | MIM:603611|HGNC:HGNC:11904|HPRD:04679| |
| Gene type | protein-coding |
| Map location | 8p21 |
| Pascal p-value | 0.044 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| GSMA_I | Genome scan meta-analysis | Psr: 0.031 | |
| GSMA_IIE | Genome scan meta-analysis (European-ancestry samples) | Psr: 0.00057 | |
| GSMA_IIA | Genome scan meta-analysis (All samples) | Psr: 0.03086 |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section III. Gene Ontology annotation
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|---|---|---|---|
| GO:0004872 | receptor activity | NAS | 9311998 | |
| GO:0005035 | death receptor activity | TAS | 9082980 | |
| GO:0008656 | caspase activator activity | NAS | - | |
| GO:0045569 | TRAIL binding | NAS | 9373179 | |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0008625 | induction of apoptosis via death domain receptors | NAS | 9311998 | |
| GO:0007250 | activation of NF-kappaB-inducing kinase activity | NAS | 9430227 |11464292 | |
| GO:0006917 | induction of apoptosis | NAS | 9311998 | |
| GO:0007165 | signal transduction | TAS | 9082980 | |
| GO:0006919 | caspase activation | NAS | - | |
| GO:0006915 | apoptosis | IEA | - | |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
| GO:0016020 | membrane | IEA | - | |
| GO:0016021 | integral to membrane | IC | 9311998 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| BCL10 | CARMEN | CIPER | CLAP | c-E10 | mE10 | B-cell CLL/lymphoma 10 | - | HPRD,BioGRID | 10400625 |
| CASP10 | ALPS2 | FLICE2 | MCH4 | caspase 10, apoptosis-related cysteine peptidase | Affinity Capture-Western | BioGRID | 9325248 |
| CASP8 | ALPS2B | CAP4 | FLICE | FLJ17672 | MACH | MCH5 | MGC78473 | caspase 8, apoptosis-related cysteine peptidase | Affinity Capture-Western | BioGRID | 9325248 |
| CASP8 | ALPS2B | CAP4 | FLICE | FLJ17672 | MACH | MCH5 | MGC78473 | caspase 8, apoptosis-related cysteine peptidase | - | HPRD | 12218097 |
| CD4 | CD4mut | CD4 molecule | - | HPRD | 7650480 |
| CFLAR | CASH | CASP8AP1 | CLARP | Casper | FLAME | FLAME-1 | FLAME1 | FLIP | I-FLICE | MRIT | c-FLIP | c-FLIPL | c-FLIPR | c-FLIPS | CASP8 and FADD-like apoptosis regulator | Affinity Capture-Western | BioGRID | 9325248 |
| COL2A1 | ANFH | AOM | COL11A3 | MGC131516 | SEDC | collagen, type II, alpha 1 | - | HPRD,BioGRID | 9811967 |
| DAP3 | DAP-3 | DKFZp686G12159 | MGC126058 | MGC126059 | MRP-S29 | MRPS29 | bMRP-10 | death associated protein 3 | - | HPRD,BioGRID | 11376335 |
| FADD | GIG3 | MGC8528 | MORT1 | Fas (TNFRSF6)-associated via death domain | - | HPRD,BioGRID | 9430227 |11376335 |
| MOAP1 | MAP-1 | PNMA4 | modulator of apoptosis 1 | TRAIL-R1 interacts with MAP-1. | BIND | 15949439 |
| RASSF1 | 123F2 | NORE2A | RASSF1A | RDA32 | REH3P21 | Ras association (RalGDS/AF-6) domain family member 1 | TRAIL-R1 interacts with RASSF1A. | BIND | 15949439 |
| RIPK1 | FLJ39204 | RIP | RIP1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | - | HPRD | 9430227 |
| TNFSF10 | APO2L | Apo-2L | CD253 | TL2 | TRAIL | tumor necrosis factor (ligand) superfamily, member 10 | - | HPRD,BioGRID | 9082980 |10549288 |
| TRADD | Hs.89862 | MGC11078 | TNFRSF1A-associated via death domain | - | HPRD,BioGRID | 9430227 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG CYTOKINE CYTOKINE RECEPTOR INTERACTION | 267 | 161 | All SZGR 2.0 genes in this pathway |
| KEGG APOPTOSIS | 88 | 62 | All SZGR 2.0 genes in this pathway |
| KEGG NATURAL KILLER CELL MEDIATED CYTOTOXICITY | 137 | 92 | All SZGR 2.0 genes in this pathway |
| BIOCARTA DEATH PATHWAY | 33 | 24 | All SZGR 2.0 genes in this pathway |
| PID TRAIL PATHWAY | 28 | 20 | All SZGR 2.0 genes in this pathway |
| PID P53 DOWNSTREAM PATHWAY | 137 | 94 | All SZGR 2.0 genes in this pathway |
| GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS GREEN UP | 23 | 19 | All SZGR 2.0 genes in this pathway |
| KOKKINAKIS METHIONINE DEPRIVATION 48HR UP | 128 | 95 | All SZGR 2.0 genes in this pathway |
| KOKKINAKIS METHIONINE DEPRIVATION 96HR UP | 117 | 84 | All SZGR 2.0 genes in this pathway |
| STREICHER LSM1 TARGETS DN | 19 | 13 | All SZGR 2.0 genes in this pathway |
| DUTTA APOPTOSIS VIA NFKB | 33 | 25 | All SZGR 2.0 genes in this pathway |
| JAZAG TGFB1 SIGNALING VIA SMAD4 DN | 66 | 38 | All SZGR 2.0 genes in this pathway |
| MURAKAMI UV RESPONSE 6HR UP | 37 | 31 | All SZGR 2.0 genes in this pathway |
| BILD HRAS ONCOGENIC SIGNATURE | 261 | 166 | All SZGR 2.0 genes in this pathway |
| SARRIO EPITHELIAL MESENCHYMAL TRANSITION UP | 180 | 114 | All SZGR 2.0 genes in this pathway |
| MARZEC IL2 SIGNALING UP | 115 | 80 | All SZGR 2.0 genes in this pathway |
| NOUSHMEHR GBM SOMATIC MUTATED | 9 | 7 | All SZGR 2.0 genes in this pathway |
| PEDERSEN METASTASIS BY ERBB2 ISOFORM 7 | 403 | 240 | All SZGR 2.0 genes in this pathway |
| KUMAR PATHOGEN LOAD BY MACROPHAGES | 275 | 155 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |