Gene Page: RGN

Summary ?
GeneID9104
SymbolRGN
SynonymsGNL|HEL-S-41|RC|SMP30
Descriptionregucalcin
ReferenceMIM:300212|HGNC:HGNC:9989|Ensembl:ENSG00000130988|HPRD:02196|Vega:OTTHUMG00000021435
Gene typeprotein-coding
Map locationXp11.3
Sherlock p-value0.063
Fetal beta-1.443

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AP000751.30.950.93
DOCK30.910.92
MADD0.910.93
KALRN0.910.91
LMTK20.910.91
PRKCE0.910.93
GAS70.910.90
STXBP10.910.92
CAMKK20.910.90
GRAMD1B0.900.89
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
RAB34-0.56-0.64
DBI-0.55-0.65
RHOC-0.54-0.63
AP002478.3-0.52-0.62
C1orf54-0.51-0.67
AL139819.3-0.51-0.59
ACSF2-0.51-0.57
S100A16-0.51-0.57
TLCD1-0.50-0.54
FXYD1-0.50-0.54

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005509calcium ion bindingISS-
GO:0030234enzyme regulator activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006874cellular calcium ion homeostasisISS-
GO:0032781positive regulation of ATPase activityISS-
GO:0050848regulation of calcium-mediated signalingISS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusISS-
GO:0005737cytoplasmISS-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP 1142669All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER DN 203134All SZGR 2.0 genes in this pathway
HATADA METHYLATED IN LUNG CANCER UP 390236All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC TGFA DN 6544All SZGR 2.0 genes in this pathway
LEE LIVER CANCER ACOX1 DN 6539All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC E2F1 DN 6438All SZGR 2.0 genes in this pathway
LEE LIVER CANCER DENA DN 7445All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN 546351All SZGR 2.0 genes in this pathway
LEE LIVER CANCER E2F1 DN 6442All SZGR 2.0 genes in this pathway
HSIAO LIVER SPECIFIC GENES 244154All SZGR 2.0 genes in this pathway
VARELA ZMPSTE24 TARGETS DN 3818All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP 262186All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546362All SZGR 2.0 genes in this pathway
LEE LIVER CANCER SURVIVAL UP 185112All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G123 DN 5130All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS PROLIFERATION DN 17997All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S3 266180All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING DN 225124All SZGR 2.0 genes in this pathway