SZGR2

Summary ?

GeneID	9261
Symbol	MAPKAPK2
Synonyms	MAPKAP-K2\|MK-2\|MK2
Description	mitogen-activated protein kinase-activated protein kinase 2
Reference	MIM:602006\|HGNC:HGNC:6887\|Ensembl:ENSG00000162889\|HPRD:11882\|Vega:OTTHUMG00000036342
Gene type	protein-coding
Map location	1q32
Fetal beta	0.485
DMG	1 (# studies)
eGene	Cerebellar Hemisphere

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Jaffe_2016	Genome-wide DNA methylation analysis	This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05.	1
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0312

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg25748647	1	206858094	MAPKAPK2	2.48E-8	-0.038	8.02E-6	DMG:Jaffe_2016

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
STRBP	0.90	0.93
CSDE1	0.90	0.93
STAU1	0.90	0.92
DHX29	0.90	0.92
LSG1	0.90	0.92
ZNF280D	0.90	0.93
KIF2A	0.89	0.92
ZFP28	0.89	0.92
TERF2	0.89	0.92
ACTR8	0.89	0.91

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.31	-0.78	-0.87
MT-CO2	-0.77	-0.86
IFI27	-0.75	-0.85
MT-CYB	-0.75	-0.84
AF347015.27	-0.75	-0.84
FXYD1	-0.75	-0.85
AF347015.8	-0.74	-0.85
AF347015.33	-0.74	-0.82
HIGD1B	-0.73	-0.84
HSD17B14	-0.73	-0.80

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0004871	signal transducer activity	TAS		8179591
GO:0005515	protein binding	IPI		16278218 \|17255097 \|17292828
GO:0005524	ATP binding	IEA		-
GO:0004674	protein serine/threonine kinase activity	TAS		8280084
GO:0016740	transferase activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000165	MAPKKK cascade	TAS		8179591
GO:0006468	protein amino acid phosphorylation	TAS		8179591
GO:0007265	Ras protein signal transduction	EXP		11520933
GO:0007242	intracellular signaling cascade	EXP		9297626
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	EXP		8846784
GO:0005634	nucleus	TAS		8280084

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AKT1	AKT \| MGC99656 \| PKB \| PKB-ALPHA \| PRKBA \| RAC \| RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1	-	HPRD,BioGRID	11042204
ARPC5	ARC16 \| MGC88523 \| dJ127C7.3 \| p16-Arc	actin related protein 2/3 complex, subunit 5, 16kDa	MAPKAPK2 interacts with and phosphorylates the p16-Arc Subunit of the Arp2/3 complex	BIND	12829704
CDC25B	-	cell division cycle 25 homolog B (S. pombe)	An unspecified isoform of MAPKAP kinase-2 interacts with and phosphorylates CDC25B.	BIND	15629715
EGF	HOMG4 \| URG	epidermal growth factor (beta-urogastrone)	Phenotypic Enhancement	BioGRID	9687510
ETV1	DKFZp781L0674 \| ER81 \| MGC104699 \| MGC120533 \| MGC120534	ets variant 1	Biochemical Activity	BioGRID	11551945
HNRNPA0	HNRPA0	heterogeneous nuclear ribonucleoprotein A0	MAPKAP-K2 interacts with hnRNPA0. This interaction was modeled on a demonstrated interaction between MAPKAP-K2 from an unspecified species and hnRNPA0 from human.	BIND	12456657
HSPB1	CMT2F \| DKFZp586P1322 \| HMN2B \| HS.76067 \| HSP27 \| HSP28 \| Hsp25 \| SRP27	heat shock 27kDa protein 1	-	HPRD,BioGRID	11042204
HSPB1	CMT2F \| DKFZp586P1322 \| HMN2B \| HS.76067 \| HSP27 \| HSP28 \| Hsp25 \| SRP27	heat shock 27kDa protein 1	MK2 phosphorylates Hsp27. This interaction was modelled on a demonstrated interaction between human MK2 and Hsp27 from an unspecified species.	BIND	15692053
MAPK1	ERK \| ERK2 \| ERT1 \| MAPK2 \| P42MAPK \| PRKM1 \| PRKM2 \| p38 \| p40 \| p41 \| p41mapk	mitogen-activated protein kinase 1	Affinity Capture-Western	BioGRID	15094067
MAPK14	CSBP1 \| CSBP2 \| CSPB1 \| EXIP \| Mxi2 \| PRKM14 \| PRKM15 \| RK \| SAPK2A \| p38 \| p38ALPHA	mitogen-activated protein kinase 14	-	HPRD,BioGRID	9768359 \|11042204 \|11551945
MDM2	HDMX \| MGC71221 \| hdm2	Mdm2 p53 binding protein homolog (mouse)	MDM2 (HDM2) interacts with MAPKAPK2 isoform 1 (MK2). This interaction was modeled on a demonstrated interaction between MDM2 from an unspecified species, and human MAPKAPK2.	BIND	15688025
MDM2	HDMX \| MGC71221 \| hdm2	Mdm2 p53 binding protein homolog (mouse)	MDM2 (HDM2) interacts with MAPKAPK2 (MK2) isoform 2. This interaction was modeled on a demonstrated interaction between MDM2 from an unspecified species, and human MAPKAPK2.	BIND	15688025
PHC2	EDR2 \| HPH2 \| MGC163502 \| PH2	polyhomeotic homolog 2 (Drosophila)	-	HPRD,BioGRID	15094067
SHC1	FLJ26504 \| SHC \| SHCA	SHC (Src homology 2 domain containing) transforming protein 1	-	HPRD,BioGRID	15094067
TCF3	E2A \| ITF1 \| MGC129647 \| MGC129648 \| bHLHb21	transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)	-	HPRD,BioGRID	10781029
YWHAZ	KCIP-1 \| MGC111427 \| MGC126532 \| MGC138156	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide	MAPKAPK2 interacts with and phosphorylates 14-3-3-zeta.	BIND	12861023

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG MAPK SIGNALING PATHWAY	267	205	All SZGR 2.0 genes in this pathway
KEGG VEGF SIGNALING PATHWAY	76	53	All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY	126	103	All SZGR 2.0 genes in this pathway
BIOCARTA MAPK PATHWAY	87	68	All SZGR 2.0 genes in this pathway
BIOCARTA P38MAPK PATHWAY	40	31	All SZGR 2.0 genes in this pathway
BIOCARTA HSP27 PATHWAY	15	11	All SZGR 2.0 genes in this pathway
ST P38 MAPK PATHWAY	37	28	All SZGR 2.0 genes in this pathway
PID IL2 1PATHWAY	55	43	All SZGR 2.0 genes in this pathway
PID P38 MK2 PATHWAY	21	19	All SZGR 2.0 genes in this pathway
PID P38 ALPHA BETA DOWNSTREAM PATHWAY	38	29	All SZGR 2.0 genes in this pathway
PID VEGFR1 2 PATHWAY	69	57	All SZGR 2.0 genes in this pathway
PID MAPK TRK PATHWAY	34	31	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME TRIF MEDIATED TLR3 SIGNALING	74	54	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO RAS	27	23	All SZGR 2.0 genes in this pathway
REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	137	105	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING TO ERKS	36	30	All SZGR 2.0 genes in this pathway
REACTOME P38MAPK EVENTS	13	12	All SZGR 2.0 genes in this pathway
REACTOME NUCLEAR EVENTS KINASE AND TRANSCRIPTION FACTOR ACTIVATION	24	20	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF MRNA	284	128	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF RNA	330	155	All SZGR 2.0 genes in this pathway
REACTOME MAP KINASE ACTIVATION IN TLR CASCADE	50	37	All SZGR 2.0 genes in this pathway
REACTOME MAPK TARGETS NUCLEAR EVENTS MEDIATED BY MAP KINASES	30	24	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	18	12	All SZGR 2.0 genes in this pathway
REACTOME DESTABILIZATION OF MRNA BY BRF1	17	9	All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS	84	50	All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION	77	57	All SZGR 2.0 genes in this pathway
REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP	17	7	All SZGR 2.0 genes in this pathway
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE	72	53	All SZGR 2.0 genes in this pathway
REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE	83	63	All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM	279	178	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED TLR4 SIGNALLING	93	69	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME TOLL RECEPTOR CASCADES	118	84	All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN	493	298	All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP	423	283	All SZGR 2.0 genes in this pathway
HUTTMANN B CLL POOR SURVIVAL UP	276	187	All SZGR 2.0 genes in this pathway
LIU VMYB TARGETS UP	127	78	All SZGR 2.0 genes in this pathway
LIU TARGETS OF VMYB VS CMYB DN	43	30	All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP	305	185	All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP	418	263	All SZGR 2.0 genes in this pathway
UDAYAKUMAR MED1 TARGETS DN	240	171	All SZGR 2.0 genes in this pathway
ELVIDGE HYPOXIA DN	146	94	All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN	508	354	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN UP	1142	669	All SZGR 2.0 genes in this pathway
RASHI RESPONSE TO IONIZING RADIATION 2	127	92	All SZGR 2.0 genes in this pathway
MARTORIATI MDM4 TARGETS FETAL LIVER DN	514	319	All SZGR 2.0 genes in this pathway
FALVELLA SMOKERS WITH LUNG CANCER	80	52	All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS DN	261	155	All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 1Q32 AMPLICON	13	5	All SZGR 2.0 genes in this pathway
BYSTROEM CORRELATED WITH IL5 DN	64	47	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER CIPROFIBRATE DN	66	43	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC TGFA DN	65	44	All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST UP	398	262	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC E2F1 DN	64	38	All SZGR 2.0 genes in this pathway
BROCKE APOPTOSIS REVERSED BY IL6	144	98	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER MYC DN	63	40	All SZGR 2.0 genes in this pathway
LEE LIVER CANCER E2F1 DN	64	42	All SZGR 2.0 genes in this pathway
NEMETH INFLAMMATORY RESPONSE LPS UP	88	64	All SZGR 2.0 genes in this pathway
LENAOUR DENDRITIC CELL MATURATION DN	128	90	All SZGR 2.0 genes in this pathway
BASSO CD40 SIGNALING UP	101	76	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS 8	86	57	All SZGR 2.0 genes in this pathway
VARELA ZMPSTE24 TARGETS UP	40	30	All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION MUSCLE DN	51	28	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1	528	324	All SZGR 2.0 genes in this pathway
RIGGINS TAMOXIFEN RESISTANCE DN	220	147	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP	317	208	All SZGR 2.0 genes in this pathway
MARZEC IL2 SIGNALING UP	115	80	All SZGR 2.0 genes in this pathway
TSUDA ALVEOLAR SOFT PART SARCOMA	10	7	All SZGR 2.0 genes in this pathway
MOOTHA PGC	420	269	All SZGR 2.0 genes in this pathway
GU PDEF TARGETS UP	71	49	All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION	422	277	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 17	181	101	All SZGR 2.0 genes in this pathway
ONGUSAHA BRCA1 TARGETS DN	14	9	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-137	32	39	1A,m8	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-485-3p	1524	1530	m8	hsa-miR-485-3p	GUCAUACACGGCUCUCCUCUCU
miR-9	1197	1204	1A,m8	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: MAPKAPK2