Summary ?
GeneID9463
SymbolPICK1
SynonymsPICK|PRKCABP
Descriptionprotein interacting with PRKCA 1
ReferenceMIM:605926|HGNC:HGNC:9394|Ensembl:ENSG00000100151|HPRD:16176|Vega:OTTHUMG00000151159
Gene typeprotein-coding
Map location22q13.1
Pascal p-value0.318
Sherlock p-value0.589
Fetal beta-0.319
eGeneCaudate basal ganglia
Hippocampus
Putamen basal ganglia
Myers' cis & trans
Meta
SupportPROTEIN CLUSTERING
G2Cdb.humanPSD
G2Cdb.humanPSP
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
AssociationA combined odds ratio method (Sun et al. 2008), association studies2Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 2.7105 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs6596223chr5134774309PICK194630.14trans
rs119126492238415542PICK1ENSG00000100151.112.422E-60.02-36776gtex_brain_putamen_basal
rs18834712238417510PICK1ENSG00000100151.111.929E-60.02-34808gtex_brain_putamen_basal
rs59955302238419738PICK1ENSG00000100151.112.622E-60.02-32580gtex_brain_putamen_basal
rs7139912238426043PICK1ENSG00000100151.111.922E-60.02-26275gtex_brain_putamen_basal
rs30266702238426774PICK1ENSG00000100151.111.64E-60.02-25544gtex_brain_putamen_basal
rs104276732238427551PICK1ENSG00000100151.111.891E-60.02-24767gtex_brain_putamen_basal
rs81421742238427963PICK1ENSG00000100151.111.561E-60.02-24355gtex_brain_putamen_basal
rs65190952238431917PICK1ENSG00000100151.111.551E-60.02-20401gtex_brain_putamen_basal
rs121576092238432277PICK1ENSG00000100151.111.242E-60.02-20041gtex_brain_putamen_basal
rs48217302238441587PICK1ENSG00000100151.118.873E-70.02-10731gtex_brain_putamen_basal
rs48217312238445214PICK1ENSG00000100151.119.399E-70.02-7104gtex_brain_putamen_basal
rs57568902238445400PICK1ENSG00000100151.111.083E-60.02-6918gtex_brain_putamen_basal
rs7609732238447266PICK1ENSG00000100151.119.684E-70.02-5052gtex_brain_putamen_basal
rs43848872238447365PICK1ENSG00000100151.111.12E-60.02-4953gtex_brain_putamen_basal
rs7423952238447444PICK1ENSG00000100151.119.21E-70.02-4874gtex_brain_putamen_basal
rs24134932238448295PICK1ENSG00000100151.111.424E-60.02-4023gtex_brain_putamen_basal
rs48217332238449394PICK1ENSG00000100151.112.354E-60.02-2924gtex_brain_putamen_basal
.2238449820PICK1ENSG00000100151.112.179E-60.02-2498gtex_brain_putamen_basal
rs57568942238450136PICK1ENSG00000100151.112.332E-60.02-2182gtex_brain_putamen_basal
rs20189802238450620PICK1ENSG00000100151.111.693E-60.02-1698gtex_brain_putamen_basal
rs7423962238452254PICK1ENSG00000100151.119.904E-70.02-64gtex_brain_putamen_basal
rs7384422238457329PICK1ENSG00000100151.112.578E-60.025011gtex_brain_putamen_basal
rs7384432238458681PICK1ENSG00000100151.119.904E-70.026363gtex_brain_putamen_basal
rs48217352238458969PICK1ENSG00000100151.119.904E-70.026651gtex_brain_putamen_basal
rs60009912238460484PICK1ENSG00000100151.119.904E-70.028166gtex_brain_putamen_basal
rs20763692238463652PICK1ENSG00000100151.119.904E-70.0211334gtex_brain_putamen_basal
rs20763702238463968PICK1ENSG00000100151.119.904E-70.0211650gtex_brain_putamen_basal

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
CPNE60.600.68
NELF0.580.65
PRKCG0.570.68
CD60.570.57
CNGB10.570.60
FIBCD10.560.50
SUSD40.560.61
SYT170.550.62
GALNTL40.540.53
TTC7B0.540.66
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
KIAA1949-0.27-0.22
RBMX2-0.26-0.39
ZNF193-0.25-0.18
FAM167B-0.25-0.39
TUBB2B-0.25-0.26
SH2B2-0.25-0.34
AP000349.1-0.25-0.27
SPATA9-0.25-0.26
TMSB15A-0.25-0.28
ZNF300-0.25-0.13

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005102receptor bindingISSNeurotransmitter (GO term level: 4)-
GO:0005080protein kinase C bindingISS-
GO:0008022protein C-terminus bindingIPI11343649 
GO:0016887ATPase activityISS-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0045161neuronal ion channel clusteringTASneuron (GO term level: 11)11343649 
GO:0007205activation of protein kinase C activityIDA10623590 
GO:0006468protein amino acid phosphorylationISS-
GO:0006605protein targetingIEA-
GO:0006890retrograde vesicle-mediated transport, Golgi to ERNAS10623590 
GO:0015844monoamine transportIDA11343649 
GO:0043046DNA methylation during gametogenesisTAS12138111 
GO:0043113receptor clusteringISS-
GO:0043045DNA methylation during embryonic developmentNAS12138111 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042734presynaptic membraneIDAneuron, axon, Synap (GO term level: 5)11343649 
GO:0045202synapseISSneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005794Golgi apparatusISS-
GO:0005737cytoplasmIDA11343649 
GO:0005739mitochondrionIEA-
GO:0005886plasma membraneIDA11343649 
GO:0048471perinuclear region of cytoplasmISS-
GO:0030054cell junctionIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACCN1ACCN | ASIC2 | ASIC2a | BNC1 | BNaC1 | MDEG | hBNaC1amiloride-sensitive cation channel 1, neuronalPICK1 interacts with BNC1a.BIND11802773 
ACCN1ACCN | ASIC2 | ASIC2a | BNC1 | BNaC1 | MDEG | hBNaC1amiloride-sensitive cation channel 1, neuronal-HPRD11739374 
ACCN1ACCN | ASIC2 | ASIC2a | BNC1 | BNaC1 | MDEG | hBNaC1amiloride-sensitive cation channel 1, neuronalPICK1 interacts with BNC1b.BIND11802773 
ACCN2ASIC | ASIC1 | ASIC1A | BNaC2 | hBNaC2amiloride-sensitive cation channel 2, neuronalPICK1 interacts with ASIC.BIND11802773 
ACCN2ASIC | ASIC1 | ASIC1A | BNaC2 | hBNaC2amiloride-sensitive cation channel 2, neuronal-HPRD,BioGRID11739374 |11802773 
|12578970 
BNC1BNC | BSN1 | HsT19447basonuclin 1Affinity Capture-Western
Two-hybrid
BioGRID11802773 
BTG2MGC126063 | MGC126064 | PC3 | TIS21BTG family, member 2-HPRD11237868 
EFNB1CFND | CFNS | EFL3 | EPLG2 | Elk-L | LERK2 | MGC8782ephrin-B1-HPRD,BioGRID9883737 
ERBB2CD340 | HER-2 | HER-2/neu | HER2 | NEU | NGL | TKR1v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)-HPRD,BioGRID11278603 
ERBB2IPERBIN | LAP2erbb2 interacting proteinTwo-hybridBioGRID11278603 
GRIA1GLUH1 | GLUR1 | GLURA | HBGR1 | MGC133252glutamate receptor, ionotropic, AMPA 1-HPRD,BioGRID11891216 
GRIA2GLUR2 | GLURB | GluR-K2 | HBGR2glutamate receptor, ionotropic, AMPA 2Reconstituted Complex
Two-hybrid
BioGRID11891216 
GRIA3GLUR-C | GLUR-K3 | GLUR3 | GLURC | MRX94glutamate receptor, ionotrophic, AMPA 3Reconstituted Complex
Two-hybrid
BioGRID11891216 
GRIA4GLUR4 | GLUR4C | GLURDglutamate receptor, ionotrophic, AMPA 4Reconstituted Complex
Two-hybrid
BioGRID11891216 
GRIK1EAA3 | EEA3 | GLR5 | GLUR5glutamate receptor, ionotropic, kainate 1-HPRD11891216 
GRIK1EAA3 | EEA3 | GLR5 | GLUR5glutamate receptor, ionotropic, kainate 1-HPRD,BioGRID12597860 
GRIK2EAA4 | GLR6 | GLUK6 | GLUR6 | MGC74427 | MRT6glutamate receptor, ionotropic, kainate 2-HPRD,BioGRID12597860 
GRIK3EAA5 | GLR7 | GLUR7 | GluR7aglutamate receptor, ionotropic, kainate 3Reconstituted Complex
Two-hybrid
BioGRID11891216 
GRM3GLUR3 | GPRC1C | MGLUR3 | mGlu3glutamate receptor, metabotropic 3Reconstituted Complex
Two-hybrid
BioGRID11891216 
GRM7FLJ40498 | GLUR7 | GPRC1G | MGLUR7 | mGlu7glutamate receptor, metabotropic 7PICK1 interacts with mGluR7b. This interaction was modeled on a demonstrated interaction between PICK1 from an unspecified species and human mGluR7b.BIND11891216 
GRM7FLJ40498 | GLUR7 | GPRC1G | MGLUR7 | mGlu7glutamate receptor, metabotropic 7Affinity Capture-Western
Biochemical Activity
Reconstituted Complex
Two-hybrid
BioGRID11007882 
LRP2BPDKFZp761O0113 | FLJ44965LRP2 binding protein-HPRD12508107 
PICK1MGC15204 | PICK | PRKCABPprotein interacting with PRKCA 1PICK1 interacts with another PICK1.BIND11802773 
PRKCAAAG6 | MGC129900 | MGC129901 | PKC-alpha | PKCA | PRKACAprotein kinase C, alphaAffinity Capture-WesternBioGRID11007882 
PRLHRGPR10 | GR3 | MGC126539 | MGC126541 | PrRPRprolactin releasing hormone receptorAffinity Capture-WesternBioGRID11641419 
SLC6A3DAT | DAT1solute carrier family 6 (neurotransmitter transporter, dopamine), member 3-HPRD,BioGRID11343649 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 186155All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM 279221All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 137110All SZGR 2.0 genes in this pathway
REACTOME TRAFFICKING OF AMPA RECEPTORS 2823All SZGR 2.0 genes in this pathway
REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS 1611All SZGR 2.0 genes in this pathway
GINESTIER BREAST CANCER ZNF217 AMPLIFIED DN 335193All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552347All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION UP 14293All SZGR 2.0 genes in this pathway
PENG GLUCOSE DEPRIVATION DN 169112All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN 337230All SZGR 2.0 genes in this pathway
MAGRANGEAS MULTIPLE MYELOMA IGLL VS IGLK UP 4224All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412249All SZGR 2.0 genes in this pathway
MOREAUX B LYMPHOCYTE MATURATION BY TACI UP 9258All SZGR 2.0 genes in this pathway
ZAMORA NOS2 TARGETS UP 6941All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
MCCABE BOUND BY HOXC6 469239All SZGR 2.0 genes in this pathway
MCCABE HOXC6 TARGETS CANCER UP 3123All SZGR 2.0 genes in this pathway
FIRESTEIN PROLIFERATION 175125All SZGR 2.0 genes in this pathway
FONTAINE FOLLICULAR THYROID ADENOMA DN 6845All SZGR 2.0 genes in this pathway
FONTAINE PAPILLARY THYROID CARCINOMA DN 8053All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE LATE 1137655All SZGR 2.0 genes in this pathway
KASLER HDAC7 TARGETS 1 UP 194133All SZGR 2.0 genes in this pathway
DELACROIX RARG BOUND MEF 367231All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES 462273All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-21496102m8hsa-miR-214brainACAGCAGGCACAGACAGGCAG