SZGR2

Summary ?

GeneID	9472
Symbol	AKAP6
Synonyms	ADAP100\|ADAP6\|AKAP100\|PRKA6\|mAKAP
Description	A-kinase anchoring protein 6
Reference	MIM:604691\|HGNC:HGNC:376\|HPRD:05257\|
Gene type	protein-coding
Map location	14q12
Pascal p-value	0.001
eGene	Cortex
Support	CompositeSet Darnell FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description
CV:PGCnp	Genome-wide Association Study	GWAS
GSMA_I	Genome scan meta-analysis	Psr: 0.047
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0577

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MYL6	0.85	0.86
MRPL36	0.83	0.83
ROBLD3	0.83	0.81
VPS25	0.82	0.85
SF3B5	0.81	0.85
HRAS	0.81	0.77
TSTA3	0.81	0.82
CCDC56	0.81	0.84
ATOX1	0.81	0.77
PSMA7	0.81	0.86

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
AF347015.8	-0.54	-0.56
AF347015.26	-0.53	-0.59
AF347015.18	-0.53	-0.57
AF347015.2	-0.52	-0.56
MT-ATP8	-0.52	-0.57
AF347015.15	-0.52	-0.56
AF347015.27	-0.51	-0.56
AF347015.33	-0.50	-0.55
MT-CO2	-0.49	-0.50
MT-CYB	-0.49	-0.54

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0051018	protein kinase A binding	NAS		10413680
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006605	protein targeting	NAS		7721854 \|10413680
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005634	nucleus	IEA		-
GO:0016020	membrane	IEA		-
GO:0016529	sarcoplasmic reticulum	IDA		7721854
GO:0031965	nuclear membrane	IEA		-

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP	368	234	All SZGR 2.0 genes in this pathway
DOANE RESPONSE TO ANDROGEN UP	184	125	All SZGR 2.0 genes in this pathway
VANHARANTA UTERINE FIBROID WITH 7Q DELETION DN	36	23	All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP	239	157	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR	681	420	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY 4NQO OR UV	63	44	All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE UP	226	164	All SZGR 2.0 genes in this pathway
FIRESTEIN PROLIFERATION	175	125	All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP	442	263	All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3	718	401	All SZGR 2.0 genes in this pathway
DURAND STROMA S UP	297	194	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
let-7/98	279	285	m8	hsa-let-7a^brain	UGAGGUAGUAGGUUGUAUAGUU
				hsa-let-7b^brain	UGAGGUAGUAGGUUGUGUGGUU
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	UGAGGUAGGAGGUUGUAUAGU
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	UGAGGUAGUAAGUUGUAUUGUU
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	UGAGGUAGUAGUUUGUGCUGU
miR-124.1	940	946	1A	hsa-miR-124a	UUAAGGCACGCGGUGAAUGCCA
miR-124/506	740	746	m8	hsa-miR-506	UAAGGCACCCUUCUGAGUAGA
miR-124/506	740	746	m8	hsa-miR-124^brain	UAAGGCACGCGGUGAAUGCC
miR-143	28	35	1A,m8	hsa-miR-143^brain	UGAGAUGAAGCACUGUAGCUCA
miR-153	603	609	m8	hsa-miR-153	UUGCAUAGUCACAAAAGUGA
miR-181	3095	3101	m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-185	297	304	1A,m8	hsa-miR-185^brain	UGGAGAGAAAGGCAGUUC
miR-26	414	420	m8	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	414	420	m8	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-34/449	116	122	m8	hsa-miR-34a^brain	UGGCAGUGUCUUAGCUGGUUGUU
				hsa-miR-34c	AGGCAGUGUAGUUAGCUGAUUGC
				hsa-miR-449	UGGCAGUGUAUUGUUAGCUGGU
				hsa-miR-449b	AGGCAGUGUAUUGUUAGCUGGC
miR-543	3096	3103	1A,m8	hsa-miR-543	AAACAUUCGCGGUGCACUUCU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: AKAP6