Gene Page: MTRF1

Summary ?
GeneID9617
SymbolMTRF1
SynonymsMRF1|MTTRF1|RF1
Descriptionmitochondrial translational release factor 1
ReferenceMIM:604601|HGNC:HGNC:7469|Ensembl:ENSG00000120662|HPRD:06855|Vega:OTTHUMG00000016790
Gene typeprotein-coding
Map location13q14.1-q14.3
Pascal p-value0.013
Sherlock p-value0.302
Fetal beta0.527
eGeneCerebellar Hemisphere
Cerebellum
Myers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17012924chr233612474MTRF196170.1trans
rs870686chr825253521MTRF196170.15trans
rs10521998chrX32437852MTRF196170.13trans
rs16998308chrX32442345MTRF196170.03trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
LRBA0.830.84
SPAG90.810.83
LONP20.800.83
PDZD80.800.83
IPO80.800.80
WDFY10.800.81
SCRN10.800.81
ACBD50.800.79
GZF10.800.82
LRRC580.800.83
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AF347015.21-0.59-0.54
AF347015.31-0.51-0.52
MT-CO2-0.51-0.51
C1orf54-0.50-0.49
AF347015.8-0.50-0.49
AF347015.27-0.49-0.49
MYL3-0.48-0.48
SYCP3-0.48-0.46
IL32-0.47-0.44
FXYD1-0.47-0.45

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0016149translation release factor activity, codon specificIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006449regulation of translational terminationTAS9838146 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIEA-
GO:0005739mitochondrionTAS9838146 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
HOLLMANN APOPTOSIS VIA CD40 DN 267178All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN 275168All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP 769437All SZGR 2.0 genes in this pathway
MANTOVANI NFKB TARGETS UP 4333All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS EARLY PROGENITOR 532309All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED 1229713All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS UP 388234All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540340All SZGR 2.0 genes in this pathway
SMID BREAST CANCER NORMAL LIKE UP 476285All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002 429260All SZGR 2.0 genes in this pathway
MOOTHA MITOCHONDRIA 447277All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS 535325All SZGR 2.0 genes in this pathway