SZGR2

Summary ?

GeneID	9900
Symbol	SV2A
Synonyms	SV2
Description	synaptic vesicle glycoprotein 2A
Reference	MIM:185860\|HGNC:HGNC:20566\|Ensembl:ENSG00000159164\|HPRD:08922\|Vega:OTTHUMG00000012209
Gene type	protein-coding
Map location	1q21.2
Sherlock p-value	0.983
Fetal beta	-1.32
Support	EXOCYTOSIS G2Cdb.humanPSD G2Cdb.humanPSP CompositeSet Darnell FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I	Genome scan meta-analysis	Psr: 0.0235
GSMA_IIA	Genome scan meta-analysis (All samples)	Psr: 0.00814
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
GO_Annotation	Mapping neuro-related keywords to Gene Ontology annotations	Hits with neuro-related keywords: 1

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
FAM83G	0.92	0.36
SLC5A10	0.90	0.37
ZNF521	0.82	0.40
IL28RA	0.81	0.35
EPHA1	0.80	0.26
ATBF1	0.80	0.40
HLA-DPB2	0.80	0.42
MADCAM1	0.80	0.24
FOXP2	0.79	0.18
GJD2	0.79	0.25

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
GTDC1	-0.27	-0.17
SLC26A4	-0.26	-0.22
MRGPRF	-0.25	-0.14
PPP2R5A	-0.25	-0.15
MGLL	-0.25	-0.11
IL34	-0.24	-0.16
PTGDS	-0.24	-0.15
TINAGL1	-0.24	-0.12
TESK2	-0.24	-0.18
PC	-0.24	-0.01

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005215	transporter activity	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006836	neurotransmitter transport	IEA	neuron, Neurotransmitter (GO term level: 5)	-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0045202	synapse	IEA	neuron, Synap, Neurotransmitter, Glial (GO term level: 2)	-
GO:0005737	cytoplasm	IDA		18029348
GO:0005783	endoplasmic reticulum	IDA		11256614
GO:0016020	membrane	IEA		-
GO:0016021	integral to membrane	IEA		-
GO:0030054	cell junction	IEA		-
GO:0031410	cytoplasmic vesicle	IEA		-

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG ECM RECEPTOR INTERACTION	84	53	All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN	663	425	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN	460	312	All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL UP	316	190	All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP	443	294	All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 UP	256	159	All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION	475	313	All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 DN	163	115	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL	254	164	All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION DN	287	208	All SZGR 2.0 genes in this pathway
LEE AGING MUSCLE UP	45	33	All SZGR 2.0 genes in this pathway
CHEN HOXA5 TARGETS 9HR DN	41	17	All SZGR 2.0 genes in this pathway
NAKAYAMA SOFT TISSUE TUMORS PCA2 UP	87	50	All SZGR 2.0 genes in this pathway
MIKKELSEN ES ICP WITH H3K4ME3	718	401	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP	756	494	All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP	682	440	All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION DN	1080	713	All SZGR 2.0 genes in this pathway
GUILLAUMOND KLF10 TARGETS UP	51	39	All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE VIA P38 COMPLETE	227	151	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-128	33	40	1A,m8	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	33	40	1A,m8	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-133	424	430	1A	hsa-miR-133a	UUGGUCCCCUUCAACCAGCUGU
miR-133	424	430	1A	hsa-miR-133b	UUGGUCCCCUUCAACCAGCUA
miR-137	501	508	1A,m8	hsa-miR-137	UAUUGCUUAAGAAUACGCGUAG
miR-138	1037	1043	1A	hsa-miR-138^brain	AGCUGGUGUUGUGAAUC
miR-19	245	252	1A,m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	245	252	1A,m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-218	1051	1058	1A,m8	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-22	620	626	m8	hsa-miR-22^brain	AAGCUGCCAGUUGAAGAACUGU
miR-27	34	40	m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	34	40	m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-421	617	623	1A	hsa-miR-421	GGCCUCAUUAAAUGUUUGUUG
miR-485-5p	1159	1165	1A	hsa-miR-485-5p	AGAGGCUGGCCGUGAUGAAUUC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: SV2A