Gene Page: TANK

Summary
GeneID  10010
Symbol  TANK
Synonyms  I-TRAF|TRAF2
Description  TRAF family member-associated NFKB activator
See related  HGNC:11562|MIM:603893|Ensembl:ENSG00000136560|HPRD:04870|
Locus tag  -
Gene type  protein-coding
Map location  2q24-q31
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.02395 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0193 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
MTA20.970.95
DBN10.960.97
PATZ10.960.91
ACTG10.960.96
SMARCB10.950.94
NUP620.950.94
PCIF10.950.95
GEMIN40.950.95
EIF4A10.950.94
H1FX0.950.94
Top 10 negatively co-expressed genes
C5orf53-0.73-0.79
HLA-F-0.71-0.78
AF347015.27-0.71-0.92
AF347015.31-0.70-0.90
AIFM3-0.70-0.76
AF347015.33-0.69-0.92
S100B-0.69-0.86
MT-CO2-0.69-0.91
MT-CYB-0.67-0.89
ALDOC-0.67-0.69
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI12005438 
GO:0008270zinc ion bindingIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007165signal transductionTAS8710854 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CHUKIKBKA | IKK-alpha | IKK1 | IKKA | NFKBIKA | TCF16conserved helix-loop-helix ubiquitous kinaseIKK-alpha interacts with TANK.BIND12133833 
Affinity Capture-WesternBioGRID12133833 
TANK interacts with IKK-alpha.BIND12133833 
HNRNPMDKFZp547H118 | HNRNPM4 | HNRPM | HNRPM4 | HTGR1 | NAGR1heterogeneous nuclear ribonucleoprotein M-HPRD14743216 
HSPA8HSC54 | HSC70 | HSC71 | HSP71 | HSP73 | HSPA10 | LAP1 | MGC131511 | MGC29929 | NIP71heat shock 70kDa protein 8-HPRD14743216 
IKBKBFLJ40509 | IKK-beta | IKK2 | IKKB | MGC131801 | NFKBIKBinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta-HPRD12133833 
IKBKEIKK-i | IKKE | IKKI | KIAA0151 | MGC125294 | MGC125295 | MGC125297inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon-HPRD,BioGRID10759890 
IKK-epsilon interacts with TANK.BIND12133833 
IKBKGAMCBX1 | FIP-3 | FIP3 | Fip3p | IKK-gamma | IP | IP1 | IP2 | IPD2 | NEMOinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma-HPRD,BioGRID12133833 
IKK-gamma interacts with TANK.BIND12133833 
ITGB1BP1DKFZp686K08158 | ICAP-1A | ICAP-1B | ICAP-1alpha | ICAP1 | ICAP1A | ICAP1Bintegrin beta 1 binding protein 1Affinity Capture-WesternBioGRID8710854 
MAP4K5GCKR | KHS | KHS1 | MAPKKKK5mitogen-activated protein kinase kinase kinase kinase 5-HPRD10490605 
TBK1FLJ11330 | NAK | T2KTANK-binding kinase 1-HPRD,BioGRID10581243 
TRAF1EBI6 | MGC:10353TNF receptor-associated factor 1-HPRD,BioGRID8710854 
TRAF2MGC:45012 | TRAP | TRAP3TNF receptor-associated factor 2-HPRD,BioGRID8710854 |10581243 
TRAF3CAP-1 | CD40bp | CRAF1 | LAP1TNF receptor-associated factor 3-HPRD,BioGRID8710854 
TUBA3CTUBA2 | bA408E5.3tubulin, alpha 3c-HPRD14743216 
USP7HAUSP | TEF1ubiquitin specific peptidase 7 (herpes virus-associated)-HPRD,BioGRID11279055 
ZC3H12AFLJ23231 | MCPIP | MCPIP1 | RP3-423B22.1 | dJ423B22.1zinc finger CCCH-type containing 12ATwo-hybridBioGRID16189514 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY 7151All SZGR genes in this pathway
BIOCARTA_STRESS_PATHWAY 2518All SZGR genes in this pathway
BIOCARTA_TNFR2_PATHWAY 1815All SZGR genes in this pathway
REACTOME_TRAF6_MEDIATED_IRF7_ACTIVATION 3026All SZGR genes in this pathway
REACTOME_RIG_I_MDA5_MEDIATED_INDUCTION_OF_IFN_ALPHA_BETA_PATHWAYS 7357All SZGR genes in this pathway
REACTOME_INNATE_IMMUNE_SYSTEM 279178All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
GARY_CD5_TARGETS_DN 431263All SZGR genes in this pathway
THUM_SYSTOLIC_HEART_FAILURE_UP 423283All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_UP 177110All SZGR genes in this pathway
RODRIGUES_DCC_TARGETS_DN 12184All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_1_UP 276165All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_2_UP 13983All SZGR genes in this pathway
MULLIGHAN_MLL_SIGNATURE_1_UP 380236All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_UP 341197All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_DN 214133All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP 633376All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP 722443All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_48HR_UP 12895All SZGR genes in this pathway
KOKKINAKIS_METHIONINE_DEPRIVATION_96HR_UP 11784All SZGR genes in this pathway
SCHEIDEREIT_IKK_INTERACTING_PROTEINS 5845All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
AMUNDSON_RESPONSE_TO_ARSENITE 217143All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_UP 358245All SZGR genes in this pathway
TSAI_RESPONSE_TO_IONIZING_RADIATION 149101All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_UP 769437All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
SHEN_SMARCA2_TARGETS_UP 424268All SZGR genes in this pathway
ZHANG_RESPONSE_TO_IKK_INHIBITOR_AND_TNF_UP 223140All SZGR genes in this pathway
MORI_PRE_BI_LYMPHOCYTE_DN 7749All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 555346All SZGR genes in this pathway
ALCALAY_AML_BY_NPM1_LOCALIZATION_UP 14083All SZGR genes in this pathway
THEILGAARD_NEUTROPHIL_AT_SKIN_WOUND_UP 7752All SZGR genes in this pathway
PETROVA_ENDOTHELIUM_LYMPHATIC_VS_BLOOD_DN 162102All SZGR genes in this pathway
PETROVA_PROX1_TARGETS_DN 6438All SZGR genes in this pathway
TAVOR_CEBPA_TARGETS_UP 4836All SZGR genes in this pathway
IGLESIAS_E2F_TARGETS_UP 151103All SZGR genes in this pathway
WEIGEL_OXIDATIVE_STRESS_BY_HNE_AND_H2O2 3929All SZGR genes in this pathway
HEDENFALK_BREAST_CANCER_BRACX_UP 2014All SZGR genes in this pathway
WANG_CISPLATIN_RESPONSE_AND_XPC_DN 228146All SZGR genes in this pathway
YIH_RESPONSE_TO_ARSENITE_C2 1815All SZGR genes in this pathway
KAYO_CALORIE_RESTRICTION_MUSCLE_UP 9564All SZGR genes in this pathway
BURTON_ADIPOGENESIS_6 189112All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP 783442All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_3 720440All SZGR genes in this pathway
FOSTER_TOLERANT_MACROPHAGE_UP 15692All SZGR genes in this pathway
HELLER_SILENCED_BY_METHYLATION_UP 282183All SZGR genes in this pathway
CHEN_HOXA5_TARGETS_9HR_UP 223132All SZGR genes in this pathway
SWEET_LUNG_CANCER_KRAS_UP 491316All SZGR genes in this pathway
SWEET_KRAS_ONCOGENIC_SIGNATURE 8956All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP 518299All SZGR genes in this pathway
WORSCHECH_TUMOR_EVASION_AND_TOLEROGENICITY_DN 1411All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_14 14386All SZGR genes in this pathway
BRUINS_UVC_RESPONSE_LATE 1137655All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN 882538All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_8D 882506All SZGR genes in this pathway
WAKABAYASHI_ADIPOGENESIS_PPARG_RXRA_BOUND_WITH_H4K20ME1_MARK 14582All SZGR genes in this pathway
PHONG_TNF_RESPONSE_VIA_P38_PARTIAL 160106All SZGR genes in this pathway
PHONG_TNF_RESPONSE_NOT_VIA_P38 337236All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway


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