Gene Page: BCL2L11

Summary
GeneID  10018
Symbol  BCL2L11
Synonyms  BAM|BIM|BIM-alpha6|BIM-beta6|BIM-beta7|BOD|BimEL|BimL
Description  BCL2-like 11 (apoptosis facilitator)
See related  HGNC:994|MIM:603827|Ensembl:ENSG00000153094|HPRD:04828|
Locus tag  -
Gene type  protein-coding
Map location  2q13
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0004 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00755 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
IQGAP10.810.76
WWC30.810.81
C1orf1980.810.83
NDE10.800.75
WDFY20.800.79
PHLPP10.790.78
FLNB0.790.83
SALL10.790.80
CTNNA10.790.76
FUBP30.780.76
Top 10 negatively co-expressed genes
TTC9B-0.43-0.46
SYCP3-0.42-0.39
ST20-0.39-0.43
AC044839.2-0.39-0.32
USMG5-0.39-0.45
UQCR-0.39-0.41
UQCRQ-0.39-0.41
ZFAND2A-0.39-0.41
CARD16-0.38-0.38
RERGL-0.38-0.36
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIPI10198631 |15694340 |16282323 
|17692808 
GO:0008017microtubule bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007160cell-matrix adhesionIEA-
GO:0006917induction of apoptosisTAS10381623 
GO:0008633activation of pro-apoptotic gene productsEXP14764673 
GO:0030879mammary gland developmentIEA-
GO:0035148lumen formationIEA-
GO:0046620regulation of organ growthIEA-
GO:0048563post-embryonic organ morphogenesisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP12591950 
GO:0005624membrane fractionTAS9430630 
GO:0005741mitochondrial outer membraneEXP10198631 
GO:0005886plasma membraneEXP12591950 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BCL2Bcl-2B-cell CLL/lymphoma 2-HPRD,BioGRID9430630 
Bim interacts with Bcl-2.BIND15694340 
BCL2L1BCL-XL/S | BCL2L | BCLX | Bcl-X | DKFZp781P2092 | bcl-xL | bcl-xSBCL2-like 1-HPRD9430630 |10198631 
|11859372|11859372 
Bim interacts with Bcl-XL.BIND15694340 
Affinity Capture-Western
FRET		BioGRID14596824 |15694340 
-HPRD11859372 
Bcl-XL interacts with Bim. This interaction was modelled on a demonstrated interaction between Bcl-XL from an unspecified species and human Bim.BIND15721256 
BCL2L2BCL-W | BCLW | KIAA0271BCL2-like 2Bim interacts with Bcl-w.BIND15694340 
Two-hybridBioGRID9731710 
DYNLL1DLC1 | DLC8 | DNCL1 | DNCLC1 | LC8 | LC8a | MGC126137 | MGC126138 | PIN | hdlc1dynein, light chain, LC8-type 1-HPRD10198631 
Reconstituted ComplexBioGRID14561217 |15193260 
DYNLL2DNCL1B | Dlc2 | MGC17810dynein, light chain, LC8-type 2Reconstituted ComplexBioGRID14561217 
FOXO3AF6q21 | DKFZp781A0677 | FKHRL1 | FKHRL1P2 | FOXO2 | FOXO3A | MGC12739 | MGC31925forkhead box O3FoxO3a interacts with the BCL2L11 (Bim) promoter.BIND15688014 
MCL1BCL2L3 | EAT | MCL1L | MCL1S | MGC104264 | MGC1839 | TMmyeloid cell leukemia sequence 1 (BCL2-related)-HPRD,BioGRID10837489 
VDAC1MGC111064 | PORIN | PORIN-31-HLvoltage-dependent anion channel 1-HPRD,BioGRID12118373 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
SA_PROGRAMMED_CELL_DEATH 129All SZGR genes in this pathway
PID_P73PATHWAY 7959All SZGR genes in this pathway
PID_FOXO_PATHWAY 4943All SZGR genes in this pathway
PID_P75_NTR_PATHWAY 6951All SZGR genes in this pathway
PID_AP1_PATHWAY 7060All SZGR genes in this pathway
REACTOME_SIGNALLING_BY_NGF 217167All SZGR genes in this pathway
REACTOME_NRAGE_SIGNALS_DEATH_THROUGH_JNK 4333All SZGR genes in this pathway
REACTOME_CELL_DEATH_SIGNALLING_VIA_NRAGE_NRIF_AND_NADE 6043All SZGR genes in this pathway
REACTOME_P75_NTR_RECEPTOR_MEDIATED_SIGNALLING 8161All SZGR genes in this pathway
REACTOME_APOPTOSIS 14894All SZGR genes in this pathway
REACTOME_ACTIVATION_OF_BH3_ONLY_PROTEINS 1712All SZGR genes in this pathway
REACTOME_INTRINSIC_PATHWAY_FOR_APOPTOSIS 3021All SZGR genes in this pathway
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN 634384All SZGR genes in this pathway
GARY_CD5_TARGETS_UP 473314All SZGR genes in this pathway
PIEPOLI_LGI1_TARGETS_UP 1511All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_DN 406230All SZGR genes in this pathway
TAKEDA_TARGETS_OF_NUP98_HOXA9_FUSION_16D_UP 175108All SZGR genes in this pathway
JAATINEN_HEMATOPOIETIC_STEM_CELL_DN 226132All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
LAU_APOPTOSIS_CDKN2A_UP 5540All SZGR genes in this pathway
CHEBOTAEV_GR_TARGETS_UP 7762All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_UP 239157All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP 612367All SZGR genes in this pathway
RAMJAUN_APOPTOSIS_BY_TGFB1_VIA_SMAD4_UP 76All SZGR genes in this pathway
MARKS_HDAC_TARGETS_UP 2315All SZGR genes in this pathway
PEREZ_TP53_TARGETS 1174695All SZGR genes in this pathway
PEREZ_TP63_TARGETS 355243All SZGR genes in this pathway
PEREZ_TP53_AND_TP63_TARGETS 205145All SZGR genes in this pathway
GALLUZZI_PERMEABILIZE_MITOCHONDRIA 4331All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_4 6134All SZGR genes in this pathway
YAN_ESCAPE_FROM_ANOIKIS 2419All SZGR genes in this pathway
MOHANKUMAR_TLX1_TARGETS_UP 414287All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_UP 236139All SZGR genes in this pathway
BROCKE_APOPTOSIS_REVERSED_BY_IL6 14498All SZGR genes in this pathway
OKUMURA_INFLAMMATORY_RESPONSE_LPS 183115All SZGR genes in this pathway
GALINDO_IMMUNE_RESPONSE_TO_ENTEROTOXIN 8567All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL 254164All SZGR genes in this pathway
DAZARD_RESPONSE_TO_UV_NHEK_UP 244151All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_10HR_UP 10169All SZGR genes in this pathway
BILD_E2F3_ONCOGENIC_SIGNATURE 246153All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_DN 373196All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_T7 9863All SZGR genes in this pathway
STEARMAN_LUNG_CANCER_EARLY_VS_LATE_DN 6139All SZGR genes in this pathway
SARRIO_EPITHELIAL_MESENCHYMAL_TRANSITION_UP 180114All SZGR genes in this pathway
MITSIADES_RESPONSE_TO_APLIDIN_UP 439257All SZGR genes in this pathway
ZHENG_GLIOBLASTOMA_PLASTICITY_DN 5839All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
FIRESTEIN_PROLIFERATION 175125All SZGR genes in this pathway
MOOTHA_HUMAN_MITODB_6_2002 429260All SZGR genes in this pathway
LEE_DIFFERENTIATING_T_LYMPHOCYTE 200115All SZGR genes in this pathway
MEISSNER_BRAIN_HCP_WITH_H3K4ME3_AND_H3K27ME3 1069729All SZGR genes in this pathway
POOLA_INVASIVE_BREAST_CANCER_UP 288168All SZGR genes in this pathway
FONTAINE_FOLLICULAR_THYROID_ADENOMA_UP 7543All SZGR genes in this pathway
FONTAINE_THYROID_TUMOR_UNCERTAIN_MALIGNANCY_UP 3623All SZGR genes in this pathway
PYEON_CANCER_HEAD_AND_NECK_VS_CERVICAL_UP 19395All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_1 6850All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_1HR_UP 6144All SZGR genes in this pathway
QI_HYPOXIA 14096All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
IKEDA_MIR30_TARGETS_DN 2724All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_7 403240All SZGR genes in this pathway
DELACROIX_RARG_BOUND_MEF 367231All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_UP 279155All SZGR genes in this pathway
VANOEVELEN_MYOGENESIS_SIN3A_TARGETS 220133All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_UP 489314All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-10411141181A,m8hsa-miR-10aUACCCUGUAGAUCCGAAUUUGUG
hsa-miR-10bUACCCUGUAGAACCGAAUUUGU
miR-101225522621A,m8hsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-124.1465471m8hsa-miR-124aUUAAGGCACGCGGUGAAUGCCA
miR-124/5064654711Ahsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-130/30140934099m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-144225622621Ahsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-148/152409441011A,m8hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-149444450m8hsa-miR-149brainUCUGGCUCCGUGUCUUCACUCC
miR-17-5p/20/93.mr/106/519.d199920061A,m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-1812082151A,m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-1940924098m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-214373437411A,m8hsa-miR-214brainACAGCAGGCACAGACAGGCAG
miR-221/222405240591A,m8hsa-miR-221brainAGCUACAUUGUCUGCUGGGUUUC
hsa-miR-222brainAGCUACAUCUGGCUACUGGGUCUC
miR-24267826851A,m8hsa-miR-24SZUGGCUCAGUUCAGCAGGAACAG
hsa-miR-24SZUGGCUCAGUUCAGCAGGAACAG
miR-25/32/92/363/367413441411A,m8hsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
hsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
miR-30-5p2882951A,m8hsa-miR-30a-5pUGUAAACAUCCUCGACUGGAAG
hsa-miR-30cbrainUGUAAACAUCCUACACUCUCAGC
hsa-miR-30dSZUGUAAACAUCCCCGACUGGAAG
hsa-miR-30bSZUGUAAACAUCCUACACUCAGCU
hsa-miR-30e-5pUGUAAACAUCCUUGACUGGA
miR-33941104116m8hsa-miR-339UCCCUGUCCUCCAGGAGCUCA
miR-376218421911A,m8hsa-miR-376aAUCAUAGAGGAAAAUCCACGU
hsa-miR-376bAUCAUAGAGGAAAAUCCAUGUU
miR-381285928651Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-4962112171Ahsa-miR-496AUUACAUGGCCAAUCUC
miR-9192719341A,m8hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
miR-93.hd/291-3p/294/295/302/372/373/52019982004m8hsa-miR-93brainAAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302aUAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302bUAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302cUAAGUGCUUCCAUGUUUCAGUGG
hsa-miR-302dUAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520eAAAGUGCUUCCUUUUUGAGGG
hsa-miR-520aAAAGUGCUUCCCUUUGGACUGU
hsa-miR-520bAAAGUGCUUCCUUUUAGAGGG
hsa-miR-520cAAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520dAAAGUGCUUCUCUUUGGUGGGUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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