Gene Page: ABI2

Summary
GeneID  10152
Symbol  ABI2
Synonyms  ABI-2|ABI2B|AIP-1|AblBP3|SSH3BP2|argBPIA|argBPIB
Description  abl interactor 2
See related  HGNC:24011|MIM:606442|Ensembl:ENSG00000138443|
Locus tag  -
Gene type  protein-coding
Map location  2q33
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0043 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
HEATR20.870.82
LLGL10.860.85
SCRIB0.860.81
RAVER10.860.83
PTBP10.860.82
ZNF2190.850.73
ZNF6870.850.83
AL161668.20.850.79
ZNF5160.840.82
TCF30.840.76
Top 10 negatively co-expressed genes
C5orf53-0.52-0.52
SYCP3-0.51-0.60
AF347015.31-0.48-0.53
AF347015.21-0.47-0.60
C1orf54-0.47-0.52
CLEC2B-0.46-0.57
CARD16-0.46-0.56
LY96-0.45-0.54
RERGL-0.45-0.57
AL050337.1-0.44-0.52
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003674molecular_functionND-
GO:0003677DNA bindingTAS7590236 
GO:0005070SH3/SH2 adaptor activityTAS7590236 
GO:0017124SH3 domain bindingTAS8649853 
GO:0008093cytoskeletal adaptor activityTAS12011975 
GO:0019900kinase bindingNAS8649853 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0016358dendrite developmentIEAneurite, dendrite (GO term level: 11)-
GO:0007010cytoskeleton organizationTAS12011975 
GO:0008150biological_processND-
GO:0008154actin polymerization or depolymerizationNAS11516653 
GO:0007611learning or memoryIEA-
GO:0006928cell motionNAS11516653 
GO:0018108peptidyl-tyrosine phosphorylationIDA17101133 
GO:0016477cell migrationIEA-
GO:0016477cell migrationTAS12011975 
GO:0043010camera-type eye developmentIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0030175filopodiumNASaxon (GO term level: 5)11516653 
GO:0030425dendriteIEAneuron, axon, dendrite (GO term level: 6)-
GO:0005829cytosolIDA17101133 
GO:0005856cytoskeletonIEA-
GO:0005737cytoplasmNAS8649853 
GO:0005737cytoplasmTAS8649853 
GO:0030027lamellipodiumNAS11516653 
GO:0005913cell-cell adherens junctionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABL1ABL | JTK7 | bcr/abl | c-ABL | p150 | v-ablc-abl oncogene 1, receptor tyrosine kinase-HPRD,BioGRID7590236 
ADAM19FKSG34 | MADDAM | MLTNBADAM metallopeptidase domain 19 (meltrin beta)ADAM19 interacts with ArgBP1. This interaction was modelled on a demonstrated interaction between mouse ADAM19 and human ArgBP1.BIND12463424 
CCDC53CGI-116coiled-coil domain containing 53Two-hybridBioGRID16189514 
IFT20-intraflagellar transport 20 homolog (Chlamydomonas)Two-hybridBioGRID16189514 
KRT15CK15 | K15 | K1COkeratin 15Two-hybridBioGRID16189514 
KRT19CK19 | K19 | K1CS | MGC15366keratin 19Two-hybridBioGRID16189514 
KRT20CD20 | CK20 | K20 | KRT21 | MGC35423keratin 20Two-hybridBioGRID16189514 
NCK2GRB4 | NCKbetaNCK adaptor protein 2Two-hybridBioGRID16189514 
PCM1PTC4pericentriolar material 1Two-hybridBioGRID16189514 
SH3KBP1CIN85 | GIG10 | MIG18SH3-domain kinase binding protein 1-HPRD,BioGRID10858458 
SNAP23HsT17016 | SNAP23A | SNAP23Bsynaptosomal-associated protein, 23kDaTwo-hybridBioGRID16189514 
VCLCMD1W | MVCLvinculinTwo-hybridBioGRID16189514 
VPS37CFLJ20847vacuolar protein sorting 37 homolog C (S. cerevisiae)-HPRD15509564 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 216144All SZGR genes in this pathway
BIOCARTA_ACTINY_PATHWAY 2014All SZGR genes in this pathway
PID_RAC1_PATHWAY 5437All SZGR genes in this pathway
CHANDRAN_METASTASIS_TOP50_DN 4526All SZGR genes in this pathway
WANG_CLIM2_TARGETS_UP 269146All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_HSC_UP 185126All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
SCHRAMM_INHBA_TARGETS_DN 2412All SZGR genes in this pathway
WOOD_EBV_EBNA1_TARGETS_UP 11071All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_UP 236139All SZGR genes in this pathway
RICKMAN_METASTASIS_UP 344180All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_48HR_DN 428306All SZGR genes in this pathway
SMITH_TERT_TARGETS_UP 14591All SZGR genes in this pathway
DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP 314201All SZGR genes in this pathway
LU_AGING_BRAIN_DN 153120All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
BILD_CTNNB1_ONCOGENIC_SIGNATURE 8252All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 528324All SZGR genes in this pathway
AMUNDSON_POOR_SURVIVAL_AFTER_GAMMA_RADIATION_8G 9562All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
CHEN_METABOLIC_SYNDROM_NETWORK 1210725All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP 518299All SZGR genes in this pathway
KYNG_RESPONSE_TO_H2O2_VIA_ERCC6_UP 4030All SZGR genes in this pathway
CHICAS_RB1_TARGETS_SENESCENT 572352All SZGR genes in this pathway
LINSLEY_MIR16_TARGETS 206127All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN 784464All SZGR genes in this pathway
VANOEVELEN_MYOGENESIS_SIN3A_TARGETS 220133All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1013333391Ahsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-13410031009m8hsa-miR-134brainUGUGACUGGUUGACCAGAGGG
miR-1443323391A,m8hsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-186399339991Ahsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-3783263321Ahsa-miR-378CUCCUGACUCCAGGUCCUGUGU
miR-539350356m8hsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
miR-544361367m8hsa-miR-544AUUCUGCAUUUUUAGCAAGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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