Gene Page: SORBS3

Summary
GeneID  10174
Symbol  SORBS3
Synonyms  SCAM-1|SCAM1|SH3D4|VINEXIN
Description  sorbin and SH3 domain containing 3
See related  HGNC:30907|MIM:610795|Ensembl:ENSG00000120896|HPRD:11535|
Locus tag  -
Gene type  protein-coding
Map location  8p21.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.031 
GSMA_IIEgenome scan meta-analysis (European-ancestry samples)Psr: 0.00057 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.03086 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.024 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
EBF10.960.46
PBX30.920.52
NTN10.900.51
ZNF5030.890.46
C10orf410.890.31
RARB0.880.37
AC010997.10.880.46
ZNF5210.880.55
AC134043.10.870.22
SERTAD40.870.47
Top 10 negatively co-expressed genes
CDADC1-0.210.07
CHPT1-0.21-0.12
INPP1-0.21-0.01
C5orf53-0.18-0.30
PTH1R-0.18-0.21
C1S-0.180.03
TMEM54-0.17-0.13
PPP2R5A-0.170.17
COPZ2-0.17-0.25
BLVRB-0.17-0.04
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005200structural constituent of cytoskeletonTAS9885244 
GO:0008134transcription factor bindingIEA-
GO:0017166vinculin bindingIPI9885244 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000122negative regulation of transcription from RNA polymerase II promoterIEA-
GO:0031589cell-substrate adhesionIEA-
GO:0043410positive regulation of MAPKKK cascadeIEA-
GO:0051495positive regulation of cytoskeleton organizationNAS9885244 
GO:0051496positive regulation of stress fiber formationIDA9885244 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005856cytoskeletonIEA-
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-
GO:0005925focal adhesionIDA9885244 
GO:0005925focal adhesionIEA-
GO:0030054cell junctionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADAMTSL4TSRC1ADAMTS-like 4Two-hybridBioGRID16189514 
CBLBDKFZp686J10223 | DKFZp779A0729 | DKFZp779F1443 | FLJ36865 | FLJ41152 | Nbla00127 | RNF56Cas-Br-M (murine) ecotropic retroviral transforming sequence bTwo-hybridBioGRID16189514 
DDX17DKFZp761H2016 | P72 | RH70DEAD (Asp-Glu-Ala-Asp) box polypeptide 17Two-hybridBioGRID16189514 
DLG5KIAA0583 | LP-DLG | P-DLG5 | PDLGdiscs, large homolog 5 (Drosophila)-HPRD,BioGRID12657639 
DMRTB1-DMRT-like family B with proline-rich C-terminal, 1Two-hybridBioGRID16189514 
DVL2-dishevelled, dsh homolog 2 (Drosophila)Two-hybridBioGRID16189514 
EFSCAS3 | CASS3 | EFS1 | EFS2 | HEFS | SINembryonal Fyn-associated substrateTwo-hybridBioGRID16189514 
FLJ12529FLJ39024 | MGC9315pre-mRNA cleavage factor I, 59 kDa subunitTwo-hybridBioGRID16189514 
FLOT1-flotillin 1Reconstituted ComplexBioGRID11481476 
HNRNPKCSBP | FLJ41122 | HNRPK | TUNPheterogeneous nuclear ribonucleoprotein KTwo-hybridBioGRID16189514 
KIAA0408FLJ43995 | RP3-403A15.2KIAA0408Two-hybridBioGRID16189514 
KIAA1217DKFZp761L0424 | MGC31990 | SKTKIAA1217Two-hybridBioGRID16189514 
MAPK1ERK | ERK2 | ERT1 | MAPK2 | P42MAPK | PRKM1 | PRKM2 | p38 | p40 | p41 | p41mapkmitogen-activated protein kinase 1Affinity Capture-Western
Biochemical Activity		BioGRID15184391 
MAPK3ERK1 | HS44KDAP | HUMKER1A | MGC20180 | P44ERK1 | P44MAPK | PRKM3mitogen-activated protein kinase 3-HPRD15184391 
RBMXHNRPG | RBMXP1 | RBMXRT | RNMX | hnRNP-GRNA binding motif protein, X-linkedTwo-hybridBioGRID16189514 
SAFB2KIAA0138scaffold attachment factor B2-HPRD,BioGRID12660241 
ZBED1ALTE | DREF | KIAA0785 | TRAMP | hDREFzinc finger, BED-type containing 1Two-hybridBioGRID16189514 
ZBTB25KUP | ZNF46zinc finger and BTB domain containing 25Two-hybridBioGRID16189514 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
REACTOME_MUSCLE_CONTRACTION 4824All SZGR genes in this pathway
REACTOME_SMOOTH_MUSCLE_CONTRACTION 2514All SZGR genes in this pathway
LIU_SOX4_TARGETS_DN 309191All SZGR genes in this pathway
DAVICIONI_MOLECULAR_ARMS_VS_ERMS_DN 182111All SZGR genes in this pathway
MULLIGHAN_NPM1_MUTATED_SIGNATURE_2_DN 7746All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP 530342All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
AMIT_EGF_RESPONSE_480_HELA 164118All SZGR genes in this pathway
AMIT_SERUM_RESPONSE_20_MCF10A 2110All SZGR genes in this pathway
LIN_APC_TARGETS 7755All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
NADLER_HYPERGLYCEMIA_AT_OBESITY 5835All SZGR genes in this pathway
PARK_HSC_AND_MULTIPOTENT_PROGENITORS 5033All SZGR genes in this pathway
LOPES_METHYLATED_IN_COLON_CANCER_DN 2826All SZGR genes in this pathway
WEST_ADRENOCORTICAL_TUMOR_DN 546362All SZGR genes in this pathway
VALK_AML_CLUSTER_10 3322All SZGR genes in this pathway
VALK_AML_WITH_EVI1 2515All SZGR genes in this pathway
DASU_IL6_SIGNALING_UP 5944All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-9407413m8hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


Copyright © Bioinformatics and Systems Medicine Laboratory All Rights Reserved since 2009.