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| GeneID |
1020
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| Symbol |
CDK5
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| Synonyms |
PSSALRE
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| Description |
cyclin-dependent kinase 5 |
| See related |
HGNC:1774|MIM:123831|HPRD:00449| |
| Locus tag |
- |
| Gene type |
protein-coding |
| Map location |
7q36 |
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| Gene set name |
Method of gene set |
Evidence |
Info |
| GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 14 | | | Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 0.152 | |
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| General Gene Expression (microarray) ? |
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| Gene Expression in Brain Regions (new) |
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| Top co-expressed genes in Brain Regions (new) |
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| Gene | Pearson's Correlation | Spearman's Correlation | | |
| Top 10 positively co-expressed genes |
| C1R | 0.66 | 0.76 | | |
| PTH1R | 0.64 | 0.68 | | |
| PLCD3 | 0.62 | 0.72 | | |
| ANKRD9 | 0.59 | 0.64 | | |
| SDSL | 0.58 | 0.63 | | |
| GNPTG | 0.57 | 0.66 | | |
| SERTAD1 | 0.57 | 0.66 | | |
| OCEL1 | 0.57 | 0.60 | | |
| ARID5A | 0.56 | 0.66 | | |
| LDHD | 0.56 | 0.61 | | |
Top 10 negatively co-expressed genes | | ZNF551 | -0.48 | -0.51 | | |
| AC004017.1 | -0.48 | -0.52 | | |
| ZNF435 | -0.48 | -0.55 | | |
| ZNF124 | -0.47 | -0.54 | | |
| MLLT3 | -0.47 | -0.49 | | |
| ZNF302 | -0.47 | -0.54 | | |
| KIAA1949 | -0.47 | -0.36 | | |
| ZNF766 | -0.47 | -0.53 | | |
| ZNF34 | -0.47 | -0.51 | | |
| PPAPDC1B | -0.47 | -0.50 | | |
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| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0004693 | cyclin-dependent protein kinase activity | TAS | neuron (GO term level: 8) | 8090221 |
| GO:0050321 | tau-protein kinase activity | ISS | Brain (GO term level: 7) | - |
| GO:0000166 | nucleotide binding | IEA | | - |
| GO:0005176 | ErbB-2 class receptor binding | ISS | | - |
| GO:0005515 | protein binding | IPI | | 12223541 |
| GO:0005515 | protein binding | ISS | | - |
| GO:0005524 | ATP binding | IEA | | - |
| GO:0016740 | transferase activity | IEA | | - |
| GO:0030549 | acetylcholine receptor activator activity | ISS | | - |
| GO:0043125 | ErbB-3 class receptor binding | ISS | | - |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0007409 | axonogenesis | IEA | neuron, axon, neurite (GO term level: 12) | - |
| GO:0008045 | motor axon guidance | IEA | neuron, axon (GO term level: 14) | - |
| GO:0030182 | neuron differentiation | ISS | neuron (GO term level: 8) | - |
| GO:0060078 | regulation of postsynaptic membrane potential | IEA | neuron, Synap, Neurotransmitter (GO term level: 9) | - |
| GO:0014044 | Schwann cell development | IEA | neuron, axon, Glial (GO term level: 10) | - |
| GO:0031175 | neurite development | ISS | neuron, axon, neurite, dendrite (GO term level: 10) | - |
| GO:0043525 | positive regulation of neuron apoptosis | ISS | neuron (GO term level: 9) | - |
| GO:0007160 | cell-matrix adhesion | IEA | | - |
| GO:0006468 | protein amino acid phosphorylation | IEA | | - |
| GO:0007049 | cell cycle | IEA | | - |
| GO:0008283 | cell proliferation | TAS | | 8090221 |
| GO:0009790 | embryonic development | ISS | | - |
| GO:0051301 | cell division | IEA | | - |
| GO:0030334 | regulation of cell migration | IEA | | - |
| GO:0043113 | receptor clustering | IEA | | - |
| GO:0045860 | positive regulation of protein kinase activity | IEA | | - |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0043025 | cell soma | ISS | axon, dendrite (GO term level: 4) | - |
| GO:0030175 | filopodium | IEA | axon (GO term level: 5) | - |
| GO:0031594 | neuromuscular junction | ISS | neuron, axon, Synap, Neurotransmitter (GO term level: 3) | - |
| GO:0030426 | growth cone | ISS | axon, dendrite (GO term level: 5) | - |
| GO:0030425 | dendrite | ISS | neuron, axon, dendrite (GO term level: 6) | - |
| GO:0030424 | axon | ISS | neuron, axon, Neurotransmitter (GO term level: 6) | - |
| GO:0005829 | cytosol | IEA | | - |
| GO:0005634 | nucleus | ISS | | - |
| GO:0005737 | cytoplasm | ISS | | - |
| GO:0016020 | membrane | ISS | | - |
| GO:0030027 | lamellipodium | IEA | | - |
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- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.
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