Gene Page: GDF11

Summary
GeneID  10220
Symbol  GDF11
Synonyms  BMP-11|BMP11
Description  growth differentiation factor 11
See related  HGNC:4216|MIM:603936|Ensembl:ENSG00000135414|HPRD:04895|
Locus tag  -
Gene type  protein-coding
Map location  12q13.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
CUL10.890.89
GRB20.890.88
EXOC10.890.88
OGFOD10.880.88
NPEPPS0.880.88
ZNF1740.880.87
PREP0.880.88
NHEDC20.880.85
GOLGA50.870.88
EIF2AK10.870.86
Top 10 negatively co-expressed genes
MT-CO2-0.82-0.79
AF347015.31-0.82-0.80
AF347015.8-0.80-0.78
AF347015.21-0.79-0.79
AF347015.2-0.79-0.80
MT-CYB-0.79-0.76
AF347015.33-0.79-0.77
AF347015.27-0.78-0.78
HIGD1B-0.76-0.76
AF347015.15-0.76-0.77
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005125cytokine activityNAS-
GO:0005515protein bindingIEA-
GO:0008083growth factor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007399nervous system developmentTASneurite (GO term level: 5)10075854 
GO:0001501skeletal system developmentTAS10391213 
GO:0001657ureteric bud developmentIEA-
GO:0009887organ morphogenesisIEA-
GO:0008285negative regulation of cell proliferationIEA-
GO:0048469cell maturationIEA-
GO:0007498mesoderm developmentTAS10075854 
GO:0031016pancreas developmentIEA-
GO:0040007growthIEA-
GO:0045596negative regulation of cell differentiationIEA-
GO:0048593camera-type eye morphogenesisIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ACVR2BACTRIIB | ActR-IIB | MGC116908activin A receptor, type IIB-HPRD,BioGRID10391213 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_UP 285181All SZGR genes in this pathway
ZHONG_RESPONSE_TO_AZACITIDINE_AND_TSA_UP 183119All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
OKUMURA_INFLAMMATORY_RESPONSE_LPS 183115All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
KYNG_DNA_DAMAGE_BY_UV 6243All SZGR genes in this pathway
KYNG_DNA_DAMAGE_UP 226164All SZGR genes in this pathway
TAVAZOIE_METASTASIS 10868All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_1HR_DN 222147All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_DN 448282All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN 1080713All SZGR genes in this pathway
RATTENBACHER_BOUND_BY_CELF1 467251All SZGR genes in this pathway
NABA_SECRETED_FACTORS 344197All SZGR genes in this pathway
NABA_MATRISOME_ASSOCIATED 753411All SZGR genes in this pathway
NABA_MATRISOME 1028559All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-25/32/92/363/3671301371A,m8hsa-miR-25brainCAUUGCACUUGUCUCGGUCUGA
hsa-miR-32UAUUGCACAUUACUAAGUUGC
hsa-miR-92UAUUGCACUUGUCCCGGCCUG
hsa-miR-367AAUUGCACUUUAGCAAUGGUGA
hsa-miR-92bSZUAUUGCACUCGUCCCGGCCUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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