Gene Page: GPHN

Summary
GeneID  10243
Symbol  GPHN
Synonyms  GEPH|GPH|GPHRYN|KIAA1385
Description  gephyrin
See related  HGNC:15465|MIM:603930|Ensembl:ENSG00000171723|HPRD:04893|
Locus tag  -
Gene type  protein-coding
Map location  14q23.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 2.648 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SPTLC10.820.82
C14orf1000.810.83
PAIP20.800.80
C6orf2110.800.81
WDR51B0.790.76
KIAA12790.790.80
COG60.790.76
USO10.780.73
UBAP10.780.77
ERGIC20.770.73
Top 10 negatively co-expressed genes
IL32-0.50-0.37
AF347015.18-0.49-0.36
AC100783.1-0.44-0.37
AC098691.2-0.44-0.32
AF347015.21-0.44-0.23
MT-CO2-0.42-0.28
AC010300.1-0.41-0.39
AF347015.2-0.41-0.27
AF347015.26-0.40-0.27
AF347015.8-0.39-0.26
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingIEA-
GO:0003824catalytic activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007529establishment of synaptic specificity at neuromuscular junctionIEAneuron, Synap (GO term level: 11)-
GO:0006777Mo-molybdopterin cofactor biosynthetic processIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005856cytoskeletonIEA-
GO:0005622intracellularIEA-
GO:0005737cytoplasmIEA-
GO:0005886plasma membraneIEA-
GO:0030054cell junctionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARHGEF9COLLYBISTIN | HPEM-2 | KIAA0424 | PEM-2 | PEM2Cdc42 guanine nucleotide exchange factor (GEF) 9-HPRD,BioGRID10607391 |11727829 
DYNLL1DLC1 | DLC8 | DNCL1 | DNCLC1 | LC8 | LC8a | MGC126137 | MGC126138 | PIN | hdlc1dynein, light chain, LC8-type 1-HPRD12097491 |14760703 
DYNLL2DNCL1B | Dlc2 | MGC17810dynein, light chain, LC8-type 2-HPRD12097491 
ENAHENA | MENA | NDPP1enabled homolog (Drosophila)-HPRD12967995 
FRAP1FLJ44809 | FRAP | FRAP2 | MTOR | RAFT1 | RAPT1FK506 binding protein 12-rapamycin associated protein 1-HPRD,BioGRID10325225 
GABARAPFLJ25768 | MGC120154 | MGC120155 | MM46GABA(A) receptor-associated protein-HPRD10900017 
GARSCMT2D | DSMAV | GlyRS | HMN5 | SMAD1glycyl-tRNA synthetasein vitro
in vivo		BioGRID10037506 
GLRB-glycine receptor, beta-HPRD,BioGRID7546736 
PFN1-profilin 1-HPRD,BioGRID9473484 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BIOCARTA_GABA_PATHWAY 1010All SZGR genes in this pathway
REACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS 5136All SZGR genes in this pathway
PARENT_MTOR_SIGNALING_UP 567375All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP 501327All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
MORI_SMALL_PRE_BII_LYMPHOCYTE_DN 7652All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR 532309All SZGR genes in this pathway
ULE_SPLICING_VIA_NOVA2 4338All SZGR genes in this pathway
BURTON_ADIPOGENESIS_5 12678All SZGR genes in this pathway
ZHENG_BOUND_BY_FOXP3 491310All SZGR genes in this pathway
ZHENG_FOXP3_TARGETS_IN_THYMUS_UP 196137All SZGR genes in this pathway
YAUCH_HEDGEHOG_SIGNALING_PARACRINE_UP 14985All SZGR genes in this pathway
GRESHOCK_CANCER_COPY_NUMBER_UP 323240All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_D_UP 8962All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_DN 366257All SZGR genes in this pathway
HOFFMANN_LARGE_TO_SMALL_PRE_BII_LYMPHOCYTE_UP 163102All SZGR genes in this pathway
CHIANG_LIVER_CANCER_SUBCLASS_CTNNB1_UP 176110All SZGR genes in this pathway
BOYLAN_MULTIPLE_MYELOMA_PCA3_UP 8054All SZGR genes in this pathway
WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_UP 397206All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_DN 448282All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1387427481Ahsa-miR-138brainAGCUGGUGUUGUGAAUC
miR-141/200a7367421Ahsa-miR-141UAACACUGUCUGGUAAAGAUGG
hsa-miR-200aUAACACUGUCUGGUAACGAUGU
miR-145600606m8hsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-15361671Ahsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-19036431A,m8hsa-miR-190UGAUAUGUUUGAUAUAUUAGGU
miR-24*3833901A,m8hsa-miR-189GUGCCUACUGAGCUGAUAUCAGU
miR-299-3p34401Ahsa-miR-299-3pUAUGUGGGAUGGUAAACCGCUU
miR-330240246m8hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-361263269m8hsa-miR-361brainUUAUCAGAAUCUCCAGGGGUAC
miR-3756947001Ahsa-miR-375UUUGUUCGUUCGGCUCGCGUGA
miR-44860671A,m8hsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-5393173231Ahsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
miR-5437807861Ahsa-miR-543AAACAUUCGCGGUGCACUUCU
miR-544302308m8hsa-miR-544AUUCUGCAUUUUUAGCAAGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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