Gene Page: SF3B4

Summary
GeneID  10262
Symbol  SF3B4
Synonyms  MGC10828|SAP49|SF3b49
Description  splicing factor 3b, subunit 4, 49kDa
See related  HGNC:10771|MIM:605593|Ensembl:ENSG00000143368|HPRD:12028|
Locus tag  -
Gene type  protein-coding
Map location  1q12-q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0235 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00814 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
SH3BP5L0.910.93
RNF400.910.93
LRRC470.910.93
PRCC0.910.93
FAM171A20.910.94
PIK3R20.910.93
STRN40.900.93
LASP10.900.93
TRIM460.900.94
YY10.890.92
Top 10 negatively co-expressed genes
MT-CO2-0.80-0.89
AF347015.31-0.79-0.87
AF347015.33-0.79-0.86
AF347015.27-0.78-0.87
MT-CYB-0.77-0.87
AF347015.8-0.76-0.87
S100B-0.75-0.82
FXYD1-0.74-0.82
COPZ2-0.74-0.80
HLA-F-0.74-0.76
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003676nucleic acid bindingIEA-
GO:0003723RNA bindingIEA-
GO:0005515protein bindingIPI14667819 
GO:0031202RNA splicing factor activity, transesterification mechanismTAS7958871 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000398nuclear mRNA splicing, via spliceosomeEXP12226669 
GO:0000398nuclear mRNA splicing, via spliceosomeIC9731529 
GO:0008380RNA splicingTAS7958871 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005681spliceosomeIDA9731529 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BMPR1A10q23del | ACVRLK3 | ALK3 | CD292bone morphogenetic protein receptor, type IA-HPRD,BioGRID15351706 
FAM115AKIAA0738family with sequence similarity 115, member ATwo-hybridBioGRID16189514 
MAPK9JNK-55 | JNK2 | JNK2A | JNK2ALPHA | JNK2B | JNK2BETA | PRKM9 | SAPK | p54a | p54aSAPKmitogen-activated protein kinase 9Two-hybridBioGRID16189514 
NCK2GRB4 | NCKbetaNCK adaptor protein 2Two-hybridBioGRID16189514 
PHF5AINI | MGC1346 | SF3b14b | bK223H9.2PHD finger protein 5A-HPRD12234937 
RNU11U11RNA, U11 small nuclearAffinity Capture-MSBioGRID15146077 
RNU12U12RNA, U12 small nuclearAffinity Capture-MSBioGRID15146077 
SF3A2PRP11 | PRPF11 | SAP62 | SF3a66splicing factor 3a, subunit 2, 66kDaAffinity Capture-MSBioGRID12234937 
SF3B1PRP10 | PRPF10 | SAP155 | SF3b155splicing factor 3b, subunit 1, 155kDaAffinity Capture-MSBioGRID12234937 
SF3B14CGI-110 | HSPC175 | Ht006 | P14 | SAP14 | SF3B14asplicing factor 3B, 14 kDa subunit-HPRD12234937 |12738865 
SF3B2SAP145 | SF3B145 | SF3b1 | SF3b150splicing factor 3b, subunit 2, 145kDaSAP145 interacts with SAP49.BIND7958871 
in vivo
Two-hybrid		BioGRID7958871 |16189514 
-HPRD7958871 |10490618 
SMNDC1SMNR | SPF30survival motor neuron domain containing 1Affinity Capture-MSBioGRID17353931 
SS18L1CREST | KIAA0693 | LP2261 | MGC26711 | MGC78386synovial sarcoma translocation gene on chromosome 18-like 1Two-hybridBioGRID16189514 
STK19D6S60 | D6S60E | G11 | HLA-RP1 | MGC117388 | RP1serine/threonine kinase 19-HPRD14667819 
TCERG1CA150 | MGC133200 | TAF2Stranscription elongation regulator 1-HPRD,BioGRID15456888 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_SPLICEOSOME 12872All SZGR genes in this pathway
REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 14077All SZGR genes in this pathway
REACTOME_MRNA_PROCESSING 16186All SZGR genes in this pathway
REACTOME_MRNA_SPLICING 11158All SZGR genes in this pathway
REACTOME_MRNA_SPLICING_MINOR_PATHWAY 4519All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
ENK_UV_RESPONSE_KERATINOCYTE_UP 530342All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
PUJANA_ATM_PCC_NETWORK 1442892All SZGR genes in this pathway
PENG_LEUCINE_DEPRIVATION_DN 187122All SZGR genes in this pathway
FLECHNER_PBL_KIDNEY_TRANSPLANT_OK_VS_DONOR_UP 151100All SZGR genes in this pathway
PENG_GLUTAMINE_DEPRIVATION_DN 337230All SZGR genes in this pathway
LENAOUR_DENDRITIC_CELL_MATURATION_DN 12890All SZGR genes in this pathway
JAZAERI_BREAST_CANCER_BRCA1_VS_BRCA2_UP 4928All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
ACEVEDO_LIVER_TUMOR_VS_NORMAL_ADJACENT_TISSUE_UP 863514All SZGR genes in this pathway
ZHANG_BREAST_CANCER_PROGENITORS_DN 14593All SZGR genes in this pathway
KIM_BIPOLAR_DISORDER_OLIGODENDROCYTE_DENSITY_CORR_UP 682440All SZGR genes in this pathway
RAO_BOUND_BY_SALL4 227149All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-13354601Ahsa-miR-133aUUGGUCCCCUUCAACCAGCUGU
hsa-miR-133bUUGGUCCCCUUCAACCAGCUA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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