Gene Page: PRMT5

Summary
GeneID  10419
Symbol  PRMT5
Synonyms  HRMT1L5|IBP72|JBP1|SKB1|SKB1Hs
Description  protein arginine methyltransferase 5
See related  HGNC:10894|MIM:604045|Ensembl:ENSG00000100462|HPRD:04955|
Locus tag  -
Gene type  protein-coding
Map location  14q11.2-q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.047 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
LITAF0.630.65
ST50.620.63
GM2A0.610.65
CHST60.610.60
PRR5L0.610.63
SLC6A90.610.56
CD440.600.59
LAMP10.590.54
CD820.590.59
FAM63A0.590.56
Top 10 negatively co-expressed genes
SATB2-0.33-0.25
TTC9B-0.33-0.34
KLHL1-0.33-0.25
NDUFAF2-0.33-0.41
MEF2C-0.33-0.26
NOX1-0.33-0.35
RPL9-0.33-0.35
AC087071.1-0.32-0.38
GNRHR-0.32-0.36
IER5L-0.31-0.29
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0016740transferase activityIEA-
GO:0008469histone-arginine N-methyltransferase activityIEA-
GO:0008168methyltransferase activityIDA15369763 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000387spliceosomal snRNP biogenesisEXP15130578 
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
GO:0007088regulation of mitosisTAS9843966 
GO:0008283cell proliferationTAS9843966 
GO:0016568chromatin modificationIEA-
GO:0035246peptidyl-arginine N-methylationIDA15369763 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CAPN1CANP | CANP1 | CANPL1 | muCANP | muCLcalpain 1, (mu/I) large subunitCAPN1 interacts with SKB1.BIND12358155 
CLNS1ACLCI | CLNS1B | IClnchloride channel, nucleotide-sensitive, 1A-HPRD9556550 |11756452 
Affinity Capture-MS
Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID9556550 |11713266 
|11756452 
CTDP1CCFDN | FCP1CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1FCP1 interacts with PRMT5.BIND15670829 
FBLFIB | FLRN | RNU3IP1fibrillarinAffinity Capture-MSBioGRID14583623 
JAK1JAK1A | JAK1B | JTK3Janus kinase 1 (a protein tyrosine kinase)-HPRD,BioGRID10531356 
JAK2JTK10Janus kinase 2 (a protein tyrosine kinase)-HPRD,BioGRID10531356 
JAK3JAK-3 | JAK3_HUMAN | JAKL | L-JAK | LJAKJanus kinase 3 (a protein tyrosine kinase, leukocyte)-HPRD,BioGRID10531356 
MBPMGC99675myelin basic protein-HPRD,BioGRID11152681 
OLA1DKFZp313H1942 | GTPBP9 | PTD004Obg-like ATPase 1Two-hybridBioGRID16169070 
PHYHIPDYRK1AP3 | KIAA0273 | PAHX-AP | PAHXAP1phytanoyl-CoA 2-hydroxylase interacting proteinTwo-hybridBioGRID16169070 
PRMT5HRMT1L5 | IBP72 | JBP1 | SKB1 | SKB1Hsprotein arginine methyltransferase 5SKB1 forms homomeric complexes, including dimers and tetramers.BIND11152681 
-HPRD,BioGRID10531356 |11152681 
SNRPD1HsT2456 | SMD1 | SNRPDsmall nuclear ribonucleoprotein D1 polypeptide 16kDa-HPRD,BioGRID11713266 
SNRPD3SMD3small nuclear ribonucleoprotein D3 polypeptide 18kDa-HPRD,BioGRID11713266 
SUPT5HFLJ34157 | SPT5 | SPT5Hsuppressor of Ty 5 homolog (S. cerevisiae)-HPRD,BioGRID12718890 
TYK2JTK1tyrosine kinase 2-HPRD,BioGRID10531356 
WDR77HKMT1069 | MEP50 | MGC2722 | Nbla10071 | RP11-552M11.3 | p44WD repeat domain 77-HPRD,BioGRID11756452 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_E2F_PATHWAY 7448All SZGR genes in this pathway
PID_HDAC_CLASSI_PATHWAY 6650All SZGR genes in this pathway
PID_P53_REGULATION_PATHWAY 5950All SZGR genes in this pathway
REACTOME_METABOLISM_OF_NON_CODING_RNA 4929All SZGR genes in this pathway
REACTOME_METABOLISM_OF_RNA 330155All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP 368234All SZGR genes in this pathway
WANG_LMO4_TARGETS_DN 352225All SZGR genes in this pathway
JAATINEN_HEMATOPOIETIC_STEM_CELL_UP 316190All SZGR genes in this pathway
ENK_UV_RESPONSE_EPIDERMIS_UP 293179All SZGR genes in this pathway
MARTORIATI_MDM4_TARGETS_FETAL_LIVER_UP 227137All SZGR genes in this pathway
FURUKAWA_DUSP6_TARGETS_PCI35_DN 7440All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
SWEET_KRAS_TARGETS_DN 6639All SZGR genes in this pathway
MANALO_HYPOXIA_DN 289166All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
TAKAO_RESPONSE_TO_UVB_RADIATION_DN 9867All SZGR genes in this pathway
JIANG_HYPOXIA_CANCER 8352All SZGR genes in this pathway
DOUGLAS_BMI1_TARGETS_UP 566371All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN 911527All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_DN 1011592All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1 528324All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_4 307185All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_DN 593372All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_DN 591366All SZGR genes in this pathway
BOCHKIS_FOXA2_TARGETS 425261All SZGR genes in this pathway
MUELLER_PLURINET 299189All SZGR genes in this pathway
COLINA_TARGETS_OF_4EBP1_AND_4EBP2 356214All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP 188121All SZGR genes in this pathway
FOURNIER_ACINAR_DEVELOPMENT_LATE_2 277172All SZGR genes in this pathway
HOSHIDA_LIVER_CANCER_SUBCLASS_S1 237159All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP 605377All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway


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