Gene Page: MAP3K2

Summary
GeneID  10746
Symbol  MAP3K2
Synonyms  MEKK2|MEKK2B
Description  mitogen-activated protein kinase kinase kinase 2
See related  HGNC:6854|MIM:609487|Ensembl:ENSG00000169967|HPRD:10068|
Locus tag  -
Gene type  protein-coding
Map location  2q14.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.023 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00755 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
PYGO20.850.87
MAGED10.850.87
KIAA15390.820.83
AC069234.10.820.87
ZMYM30.820.86
VAC140.810.85
C7orf430.810.85
EFNB30.810.85
LRRN20.810.85
RGMB0.810.84
Top 10 negatively co-expressed genes
MT-CO2-0.68-0.73
AF347015.8-0.66-0.73
AF347015.31-0.66-0.70
AF347015.21-0.66-0.76
AF347015.2-0.65-0.70
MT-CYB-0.64-0.68
AF347015.33-0.63-0.68
AF347015.27-0.63-0.69
AF347015.15-0.62-0.67
AF347015.26-0.62-0.68
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingIEA-
GO:0005515protein bindingIEA-
GO:0005524ATP bindingIEA-
GO:0004672protein kinase activityIEA-
GO:0004674protein serine/threonine kinase activityTAS8621389 
GO:0004709MAP kinase kinase kinase activityIEA-
GO:0016740transferase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006468protein amino acid phosphorylationIEA-
GO:0007257activation of JNK activityTAS8621389 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0005737cytoplasmIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
MAP2K4JNKK | JNKK1 | MAPKK4 | MEK4 | MKK4 | PRKMK4 | SEK1 | SERK1mitogen-activated protein kinase kinase 4-HPRD7997270 
MAP2K5HsT17454 | MAPKK5 | MEK5 | PRKMK5mitogen-activated protein kinase kinase 5Affinity Capture-Western
Two-hybrid		BioGRID11073940 
MEKK2 phosphorylates an unspecified isoform of MEK5. This interaction was modeled on a demonstrated interaction between MEKK2 from an unspecified species and MEK5 from an unspecified species.BIND12659851 
MAP2K7Jnkk2 | MAPKK7 | MKK7 | PRKMK7mitogen-activated protein kinase kinase 7MEKK2 phosphorylates MKK7. This interaction was modeled on a demonstrated interaction between MEKK2 from an unspecified species and MKK7 from an unspecified species.BIND12659851 
-HPRD,BioGRID10713157 
MAP3K2MEKK2 | MEKK2Bmitogen-activated protein kinase kinase kinase 2MEKK2 autophosphorylates. This interaction was modeled on a demonstrated interaction of MEKK2 from an unspecified species.BIND12659851 
MAP3K5ASK1 | MAPKKK5 | MEKK5mitogen-activated protein kinase kinase kinase 5-HPRD12912994 
MAPK8JNK | JNK1 | JNK1A2 | JNK21B1/2 | PRKM8 | SAPK1mitogen-activated protein kinase 8-HPRD,BioGRID10713157 
PKN2MGC150606 | MGC71074 | PAK2 | PRK2 | PRKCL2 | PRO2042 | Pak-2protein kinase N2-HPRD,BioGRID10818102 
SFNYWHASstratifinAffinity Capture-MSBioGRID15778465 
SH2D2AF2771 | TSAdSH2 domain protein 2AAffinity Capture-Western
Two-hybrid		BioGRID11073940 
YWHAE14-3-3E | FLJ45465 | KCIP-1 | MDCR | MDStyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide-HPRD,BioGRID9452471 
YWHAG14-3-3GAMMAtyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide-HPRD15324660 
YWHAZKCIP-1 | MGC111427 | MGC126532 | MGC138156tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide-HPRD9452471 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_MAPK_SIGNALING_PATHWAY 267205All SZGR genes in this pathway
KEGG_GAP_JUNCTION 9068All SZGR genes in this pathway
KEGG_GNRH_SIGNALING_PATHWAY 10177All SZGR genes in this pathway
BIOCARTA_MAPK_PATHWAY 8768All SZGR genes in this pathway
ST_JNK_MAPK_PATHWAY 4030All SZGR genes in this pathway
PID_ERBB1_DOWNSTREAM_PATHWAY 10578All SZGR genes in this pathway
PID_MAPK_TRK_PATHWAY 3431All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_UP 404246All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_DN 275168All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_DN 5438All SZGR genes in this pathway
SENESE_HDAC1_TARGETS_UP 457269All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_UP 501327All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP 584356All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP 811508All SZGR genes in this pathway
BENPORATH_CYCLING_GENES 648385All SZGR genes in this pathway
STARK_PREFRONTAL_CORTEX_22Q11_DELETION_UP 195138All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS 882572All SZGR genes in this pathway
CUI_TCF21_TARGETS_2_DN 830547All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_S 16286All SZGR genes in this pathway
STAMBOLSKY_TARGETS_OF_MUTATED_TP53_UP 4935All SZGR genes in this pathway
GABRIELY_MIR21_TARGETS 289187All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
LINSLEY_MIR16_TARGETS 206127All SZGR genes in this pathway
PLASARI_TGFB1_SIGNALING_VIA_NFIC_1HR_DN 10677All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN 784464All SZGR genes in this pathway
RATTENBACHER_BOUND_BY_CELF1 467251All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_1ST_EGF_PULSE_ONLY 1839928All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-10240724131Ahsa-miR-10aUACCCUGUAGAUCCGAAUUUGUG
hsa-miR-10bUACCCUGUAGAACCGAAUUUGU
miR-12228682874m8hsa-miR-122aUGGAGUGUGACAAUGGUGUUUGU
miR-129-5p276327691Ahsa-miR-129brainCUUUUUGCGGUCUGGGCUUGC
hsa-miR-129-5pCUUUUUGCGGUCUGGGCUUGCU
miR-17-5p/20/93.mr/106/519.d6571m8hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
hsa-miR-17-5pCAAAGUGCUUACAGUGCAGGUAGU
hsa-miR-20abrainUAAAGUGCUUAUAGUGCAGGUAG
hsa-miR-106aAAAAGUGCUUACAGUGCAGGUAGC
hsa-miR-106bSZUAAAGUGCUGACAGUGCAGAU
hsa-miR-20bSZCAAAGUGCUCAUAGUGCAGGUAG
hsa-miR-519dCAAAGUGCCUCCCUUUAGAGUGU
miR-1865225291A,m8hsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-2233463521Ahsa-miR-223UGUCAGUUUGUCAAAUACCCC
miR-23268626921Ahsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-262082141Ahsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-3351281341Ahsa-miR-335brainUCAAGAGCAAUAACGAAAAAUGU
miR-539124130m8hsa-miR-539GGAGAAAUUAUCCUUGGUGUGU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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