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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets

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Association Linkage Expression Literature GO_Annotation Gene Network miRNA Targets Datasets Gene Ranking

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Gene Page: GIPC1

Summary

GeneID

10755

Symbol

GIPC1

Synonyms

C19orf3|GIPC|GLUT1CBP|Hs.6454|IIP-1|MGC15889|MGC3774|NIP|RGS19IP1|SEMCAP|SYNECTIIN|SYNECTIN|TIP-2

Description

GIPC PDZ domain containing family, member 1

Locus tag

Gene type

protein-coding

Map location

19p13.1

Gene in Data Sources

Gene set name

Method of gene set

Evidence

Info

GO_Annotation

Mapping neuro-related keywords to Gene Ontology annotations

Hits with neuro-related keywords: 7

Network

Shortest path distance of core genes in the Human protein-protein interaction network

Contribution to shortest path in PPI network: 0.7595

General Gene Expression (microarray) ?

Gene Expression in Brain Regions (new)

Top co-expressed genes in Brain Regions (new)

Gene

Pearson's Correlation

Spearman's Correlation

Top 10 positively co-expressed genes

Top 10 negatively co-expressed genes

Gene Ontology

Molecular function

GO term

Evidence

Neuro keywords

PubMed ID

GO:0005102

receptor binding

IPI

Neurotransmitter (GO term level: 4)

15459234

GO:0003779

actin binding

IEA

GO:0017022

myosin binding

IEA

GO:0042803

protein homodimerization activity

IEA

Biological process

GO term

Evidence

Neuro keywords

PubMed ID

GO:0007268

synaptic transmission

IEA

neuron, Synap, Neurotransmitter (GO term level: 6)

GO:0014047

glutamate secretion

IEA

glutamate, Neurotransmitter (GO term level: 7)

GO:0048167

regulation of synaptic plasticity

IEA

Synap (GO term level: 8)

GO:0007186

G-protein coupled receptor protein signaling pathway

NAS

9770488

GO:0006605

protein targeting

IEA

GO:0030511

positive regulation of transforming growth factor beta receptor signaling pathway

ISS

GO:0032435

negative regulation of proteasomal ubiquitin-dependent protein catabolic process

ISS

GO:0031647

regulation of protein stability

ISS

GO:0043542

endothelial cell migration

IEA

Cellular component

GO term

Evidence

Neuro keywords

PubMed ID

GO:0008021

synaptic vesicle

IEA

Synap, Neurotransmitter (GO term level: 12)

GO:0043198

dendritic shaft

IEA

dendrite (GO term level: 7)

GO:0043197

dendritic spine

IEA

Synap, dendrite (GO term level: 7)

GO:0012506

vesicle membrane

IEA

GO:0005829

cytosol

ISS

GO:0005624

membrane fraction

IDA

9770488

GO:0005625

soluble fraction

IDA

9770488

GO:0005737

cytoplasm

IEA

GO:0016020

membrane

ISS

GO:0016023

cytoplasmic membrane-bounded vesicle

IDA

12857860

GO:0005938

cell cortex

IDA

12857860

Protein-protein Interactions

Shown by network

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ACTN1	FLJ40884	actinin, alpha 1	Affinity Capture-Western Reconstituted Complex	BioGRID	10198040
ADRB1	ADRB1R \| B1AR \| BETA1AR \| RHR	adrenergic, beta-1-, receptor	Affinity Capture-Western Two-hybrid	BioGRID	12724327
ADRB1	ADRB1R \| B1AR \| BETA1AR \| RHR	adrenergic, beta-1-, receptor	The carboxy terminus of beta-1-AR interacts with GIPC.	BIND	12724327
CD93	C1QR1 \| C1qR(P) \| C1qRP \| CDw93 \| MXRA4 \| dJ737E23.1	CD93 molecule	CD93 interacts with GIPC.	BIND	15459234
CD93	C1QR1 \| C1qR(P) \| C1qRP \| CDw93 \| MXRA4 \| dJ737E23.1	CD93 molecule	GIPC interacts with CD93. This interaction was modelled on a demonstrated interaction between GIPC from an unspecified species and human CD93.	BIND	15819698
DRD3	D3DR \| ETM1 \| FET1 \| MGC149204 \| MGC149205	dopamine receptor D3	Two-hybrid	BioGRID	14499480
GEMIN4	DKFZp434B131 \| DKFZp434D174 \| HC56 \| HCAP1 \| HHRF-1 \| p97	gem (nuclear organelle) associated protein 4	Affinity Capture-MS	BioGRID	17353931
ITGA5	CD49e \| FNRA \| VLA5A	integrin, alpha 5 (fibronectin receptor, alpha polypeptide)	-	HPRD,BioGRID	11479315
ITGA6	CD49f \| DKFZp686J01244 \| FLJ18737 \| ITGA6B \| VLA-6	integrin, alpha 6	-	HPRD,BioGRID	11479315
KIF1B	CMT2 \| CMT2A \| CMT2A1 \| FLJ23699 \| HMSNII \| KIAA0591 \| KIAA1448 \| KLP \| MGC134844	kinesin family member 1B	-	HPRD,BioGRID	10198040
LHCGR	FLJ41504 \| LCGR \| LGR2 \| LH/CG-R \| LH/CGR \| LHR \| LHRHR \| LSH-R	luteinizing hormone/choriogonadotropin receptor	Affinity Capture-Western Reconstituted Complex Two-hybrid	BioGRID	14507927
LHCGR		luteinizing hormone/choriogonadotropin receptor	GIPC interacts with hLHR.	BIND	14507927
LRP1	A2MR \| APOER \| APR \| CD91 \| FLJ16451 \| IGFBP3R \| LRP \| MGC88725 \| TGFBR5	low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)	Reconstituted Complex Two-hybrid	BioGRID	10827173
LRP2	DBS \| gp330	low density lipoprotein-related protein 2	-	HPRD,BioGRID	11912251
LRP8	APOER2 \| HSZ75190 \| MCI1	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor	Two-hybrid	BioGRID	10827173
MARS	FLJ35667 \| METRS \| MTRNS	methionyl-tRNA synthetase	Affinity Capture-MS	BioGRID	17353931
MCM7	CDABP0042 \| CDC47 \| MCM2 \| P1.1-MCM3 \| P1CDC47 \| P85MCM \| PNAS-146	minichromosome maintenance complex component 7	Affinity Capture-MS	BioGRID	17353931
MMS19	FLJ34167 \| FLJ95146 \| MET18 \| MGC99604 \| MMS19L \| hMMS19	MMS19 nucleotide excision repair homolog (S. cerevisiae)	Affinity Capture-MS	BioGRID	17353931
MYO1C	FLJ23903 \| MMI-beta \| MMIb \| NMI \| myr2	myosin IC	Affinity Capture-MS	BioGRID	17353931
MYO6	DFNA22 \| DFNB37 \| KIAA0389	myosin VI	-	HPRD	12857860 \|12893809
MYO6	DFNA22 \| DFNB37 \| KIAA0389	myosin VI	Affinity Capture-MS Affinity Capture-Western	BioGRID	12857860 \|17353931
NTRK1	DKFZp781I14186 \| MTC \| TRK \| TRK1 \| TRKA \| p140-TrkA	neurotrophic tyrosine kinase, receptor, type 1	GIPC interacts with TRKA. This interaction was modelled on a demonstrated interaction between mouse GIPC and rat TrkA.	BIND	11251075
NTRK1	DKFZp781I14186 \| MTC \| TRK \| TRK1 \| TRKA \| p140-TrkA	neurotrophic tyrosine kinase, receptor, type 1	-	HPRD,BioGRID	11251075
NTRK2	GP145-TrkB \| TRKB	neurotrophic tyrosine kinase, receptor, type 2	-	HPRD,BioGRID	11251075
NUP93	KIAA0095 \| MGC21106	nucleoporin 93kDa	Affinity Capture-MS	BioGRID	17353931
PDXDC1	KIAA0251 \| LP8165	pyridoxal-dependent decarboxylase domain containing 1	Affinity Capture-MS	BioGRID	17353931
RGS1	1R20 \| BL34 \| IER1 \| IR20	regulator of G-protein signaling 1	-	HPRD	11251075
RGS19	GAIP \| RGSGAIP	regulator of G-protein signaling 19	GAIP interacts with GIPC. This interaction was modelled on a demonstrated interaction between human GAIP and mouse GIPC.	BIND	11251075
RGS19	GAIP \| RGSGAIP	regulator of G-protein signaling 19	-	HPRD,BioGRID	9770488 \|11251075 \|11956658
SDC4	MGC22217 \| SYND4	syndecan 4	Affinity Capture-Western	BioGRID	10911369
SEMA4C	FLJ20369 \| KIAA1739 \| M-SEMA-F \| MGC126382 \| MGC126383 \| SEMACL1 \| SEMAF \| SEMAI	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C	in vitro in vivo	BioGRID	10318831
SH3BP4	BOG25 \| TTP	SH3-domain binding protein 4	Affinity Capture-MS	BioGRID	17353931
SLC2A1	DYT17 \| DYT18 \| GLUT \| GLUT1 \| MGC141895 \| MGC141896 \| PED	solute carrier family 2 (facilitated glucose transporter), member 1	-	HPRD,BioGRID	10198040
TAGLN	DKFZp686P11128 \| SM22 \| SMCC \| TAGLN1 \| WS3-10	transgelin	Affinity Capture-MS	BioGRID	17353931
TPBG	5T4 \| 5T4-AG \| M6P1	trophoblast glycoprotein	-	HPRD,BioGRID	11798178
TYRP1	CAS2 \| CATB \| GP75 \| TRP \| TYRP \| b-PROTEIN	tyrosinase-related protein 1	-	HPRD,BioGRID	11441007
ZFPM1	FOG \| FOG1 \| ZNF408 \| ZNF89A	zinc finger protein, multitype 1	-	HPRD,BioGRID	15231747

Pathway annotation

Pathway name	Pathway size	# SZGR genes in pathway	Info
PID_SYNDECAN_4_PATHWAY	32	25	All SZGR genes in this pathway
PID_TRKR_PATHWAY	62	48	All SZGR genes in this pathway
TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_ERYTHROCYTE_UP	157	104	All SZGR genes in this pathway
WAMUNYOKOLI_OVARIAN_CANCER_LMP_UP	265	158	All SZGR genes in this pathway
CHIARADONNA_NEOPLASTIC_TRANSFORMATION_CDC25_DN	153	100	All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_UP	479	299	All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN	848	527	All SZGR genes in this pathway
CAFFAREL_RESPONSE_TO_THC_DN	31	23	All SZGR genes in this pathway
CAFFAREL_RESPONSE_TO_THC_24HR_3_DN	13	8	All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_WELL_VS_POORLY_DN	382	224	All SZGR genes in this pathway
RICKMAN_METASTASIS_DN	261	155	All SZGR genes in this pathway
SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN	514	330	All SZGR genes in this pathway
LIN_APC_TARGETS	77	55	All SZGR genes in this pathway
BYSTRYKH_HEMATOPOIESIS_STEM_CELL_QTL_TRANS	882	572	All SZGR genes in this pathway
YAGI_AML_FAB_MARKERS	191	131	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_UP	390	242	All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP	1691	1088	All SZGR genes in this pathway
LU_AGING_BRAIN_UP	262	186	All SZGR genes in this pathway
SANSOM_APC_TARGETS_REQUIRE_MYC	210	123	All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP	1305	895	All SZGR genes in this pathway
GOBERT_OLIGODENDROCYTE_DIFFERENTIATION_DN	1080	713	All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_DN	428	246	All SZGR genes in this pathway

miRNA Targets ?

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
let-7/98	230	237	1A,m8	hsa-let-7a^brain	UGAGGUAGUAGGUUGUAUAGUU
				hsa-let-7b^brain	UGAGGUAGUAGGUUGUGUGGUU
				hsa-let-7c^brain	UGAGGUAGUAGGUUGUAUGGUU
				hsa-let-7d^brain	AGAGGUAGUAGGUUGCAUAGU
				hsa-let-7e^brain	UGAGGUAGGAGGUUGUAUAGU
				hsa-let-7f^brain	UGAGGUAGUAGAUUGUAUAGUU
				hsa-miR-98^brain	UGAGGUAGUAAGUUGUAUUGUU
				hsa-let-7g^SZ	UGAGGUAGUAGUUUGUACAGU
				hsa-let-7i^brain	UGAGGUAGUAGUUUGUGCUGU
miR-194	481	487	m8	hsa-miR-194	UGUAACAGCAACUCCAUGUGGA
miR-491	223	229	m8	hsa-miR-491^brain	AGUGGGGAACCCUUCCAUGAGGA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.